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Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA : Methodological limitations and convergent results

Linguiti, Sophia ; Vogel, Jacob W. LU ; Sydnor, Valerie J. ; Pines, Adam ; Wellman, Nick ; Basbaum, Allan ; Eickhoff, Claudia R. ; Eickhoff, Simon B. ; Edwards, Robert R. and Larsen, Bart , et al. (2023) In Neuroscience and Biobehavioral Reviews 154.
Abstract

Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study the acute impact of psychedelics on the human brain. While fMRI is a promising tool for measuring brain function in response to psychedelics, it also has known methodological challenges. We conducted a systematic review of fMRI studies examining acute responses to experimentally administered psychedelics in order to identify convergent findings and characterize heterogeneity in the literature. We reviewed 91 full-text papers; these studies were notable for substantial heterogeneity in design, task, dosage, drug timing, and statistical approach. Data recycling was common, with 51 unique samples across 91 studies. Fifty-seven studies (54%) did not... (More)

Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study the acute impact of psychedelics on the human brain. While fMRI is a promising tool for measuring brain function in response to psychedelics, it also has known methodological challenges. We conducted a systematic review of fMRI studies examining acute responses to experimentally administered psychedelics in order to identify convergent findings and characterize heterogeneity in the literature. We reviewed 91 full-text papers; these studies were notable for substantial heterogeneity in design, task, dosage, drug timing, and statistical approach. Data recycling was common, with 51 unique samples across 91 studies. Fifty-seven studies (54%) did not meet contemporary standards for Type I error correction or control of motion artifact. Psilocybin and LSD were consistently reported to moderate the connectivity architecture of the sensorimotor-association cortical axis. Studies also consistently reported that ketamine administration increased activation in the dorsomedial prefrontal cortex. Moving forward, use of best practices such as pre-registration, standardized image processing and statistical testing, and data sharing will be important in this rapidly developing field.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
FMRI, Functional magnetic resonance imaging, Ketamine, LSD, MDMA, Psilocybin, Psychedelics
in
Neuroscience and Biobehavioral Reviews
volume
154
article number
105421
publisher
Elsevier
external identifiers
  • pmid:37802267
  • scopus:85173541823
ISSN
0149-7634
DOI
10.1016/j.neubiorev.2023.105421
language
English
LU publication?
yes
id
38be3c71-e9dd-4546-91b4-1e37154012be
date added to LUP
2023-12-05 14:26:44
date last changed
2024-04-18 10:03:45
@article{38be3c71-e9dd-4546-91b4-1e37154012be,
  abstract     = {{<p>Functional magnetic resonance imaging (fMRI) is increasingly used to non-invasively study the acute impact of psychedelics on the human brain. While fMRI is a promising tool for measuring brain function in response to psychedelics, it also has known methodological challenges. We conducted a systematic review of fMRI studies examining acute responses to experimentally administered psychedelics in order to identify convergent findings and characterize heterogeneity in the literature. We reviewed 91 full-text papers; these studies were notable for substantial heterogeneity in design, task, dosage, drug timing, and statistical approach. Data recycling was common, with 51 unique samples across 91 studies. Fifty-seven studies (54%) did not meet contemporary standards for Type I error correction or control of motion artifact. Psilocybin and LSD were consistently reported to moderate the connectivity architecture of the sensorimotor-association cortical axis. Studies also consistently reported that ketamine administration increased activation in the dorsomedial prefrontal cortex. Moving forward, use of best practices such as pre-registration, standardized image processing and statistical testing, and data sharing will be important in this rapidly developing field.</p>}},
  author       = {{Linguiti, Sophia and Vogel, Jacob W. and Sydnor, Valerie J. and Pines, Adam and Wellman, Nick and Basbaum, Allan and Eickhoff, Claudia R. and Eickhoff, Simon B. and Edwards, Robert R. and Larsen, Bart and McKinstry-Wu, Andrew and Scott, J. Cobb and Roalf, David R. and Sharma, Vaishnavi and Strain, Eric C. and Corder, Gregory and Dworkin, Robert H. and Satterthwaite, Theodore D.}},
  issn         = {{0149-7634}},
  keywords     = {{FMRI; Functional magnetic resonance imaging; Ketamine; LSD; MDMA; Psilocybin; Psychedelics}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Neuroscience and Biobehavioral Reviews}},
  title        = {{Functional imaging studies of acute administration of classic psychedelics, ketamine, and MDMA : Methodological limitations and convergent results}},
  url          = {{http://dx.doi.org/10.1016/j.neubiorev.2023.105421}},
  doi          = {{10.1016/j.neubiorev.2023.105421}},
  volume       = {{154}},
  year         = {{2023}},
}