Advanced

All-cause mortality in 272 186 patients hospitalized with incident atrial fibrillation 1995-2008: a Swedish nationwide long-term case-control study

Andersson, Tommy; Magnuson, Anders; Bryngelsson, Ing-Liss; Frobert, Ole; Henriksson, Karin LU ; Edvardsson, Nils and Poci, Dritan (2013) In European Heart Journal 34(14). p.1061-1067
Abstract
Aims To evaluate long-term all-cause risk of mortality in women and men hospitalized for the first time with atrial fibrillation (AF) compared with matched controls. Methods and results A total of 272 186 patients (44% women) <= 85 years at the time of hospitalization with incidental AF 1995-2008 and 544 344 matched controls free of in-hospital diagnosis of AF were identified. Patients were followed via record linkage of the Swedish National Patient Registry and the Cause of Death Registry. Using Cox regression models, the long-term relative all-cause mortality risk, adjusted for concomitant diseases, in women vs. controls was 2.15, 1.72, and 1.44 (P < 0.001) in the age categories <= 65, 65-74, and 75-85 years, respectively. The... (More)
Aims To evaluate long-term all-cause risk of mortality in women and men hospitalized for the first time with atrial fibrillation (AF) compared with matched controls. Methods and results A total of 272 186 patients (44% women) <= 85 years at the time of hospitalization with incidental AF 1995-2008 and 544 344 matched controls free of in-hospital diagnosis of AF were identified. Patients were followed via record linkage of the Swedish National Patient Registry and the Cause of Death Registry. Using Cox regression models, the long-term relative all-cause mortality risk, adjusted for concomitant diseases, in women vs. controls was 2.15, 1.72, and 1.44 (P < 0.001) in the age categories <= 65, 65-74, and 75-85 years, respectively. The corresponding figures for men were 1.76, 1.36, and 1.24 (P < 0.001). Among concomitant diseases, neoplasm, chronic renal failure, and chronic obstructive pulmonary disease contributed most to the increased all-cause mortality vs. controls. In patients with AF as the primary diagnosis, the relative risk of mortality was 1.63, 1.46, and 1.28 (P < 0.001) in women and 1.45, 1.17, and 1.10 (P < 0.001) in men. Conclusion Atrial fibrillation was an independent risk factor of all-cause mortality in patients with incident AF. The concomitant diseases that contributed most were found outside the thromboembolic risk scores. The highest relative risk of mortality was seen in women and in the youngest patients compared with controls, and the differences between genders in each age category were statistically significant. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atrial fibrillation, Mortality, Gender, Age, Long term
in
European Heart Journal
volume
34
issue
14
pages
1061 - 1067
publisher
Oxford University Press
external identifiers
  • wos:000317424300014
  • scopus:84876218799
ISSN
1522-9645
DOI
10.1093/eurheartj/ehs469
language
English
LU publication?
yes
id
38c6e8b3-d1d4-4803-8e75-e00c67d26471 (old id 3739144)
date added to LUP
2013-06-03 08:32:26
date last changed
2019-08-25 04:09:00
@article{38c6e8b3-d1d4-4803-8e75-e00c67d26471,
  abstract     = {Aims To evaluate long-term all-cause risk of mortality in women and men hospitalized for the first time with atrial fibrillation (AF) compared with matched controls. Methods and results A total of 272 186 patients (44% women) &lt;= 85 years at the time of hospitalization with incidental AF 1995-2008 and 544 344 matched controls free of in-hospital diagnosis of AF were identified. Patients were followed via record linkage of the Swedish National Patient Registry and the Cause of Death Registry. Using Cox regression models, the long-term relative all-cause mortality risk, adjusted for concomitant diseases, in women vs. controls was 2.15, 1.72, and 1.44 (P &lt; 0.001) in the age categories &lt;= 65, 65-74, and 75-85 years, respectively. The corresponding figures for men were 1.76, 1.36, and 1.24 (P &lt; 0.001). Among concomitant diseases, neoplasm, chronic renal failure, and chronic obstructive pulmonary disease contributed most to the increased all-cause mortality vs. controls. In patients with AF as the primary diagnosis, the relative risk of mortality was 1.63, 1.46, and 1.28 (P &lt; 0.001) in women and 1.45, 1.17, and 1.10 (P &lt; 0.001) in men. Conclusion Atrial fibrillation was an independent risk factor of all-cause mortality in patients with incident AF. The concomitant diseases that contributed most were found outside the thromboembolic risk scores. The highest relative risk of mortality was seen in women and in the youngest patients compared with controls, and the differences between genders in each age category were statistically significant.},
  author       = {Andersson, Tommy and Magnuson, Anders and Bryngelsson, Ing-Liss and Frobert, Ole and Henriksson, Karin and Edvardsson, Nils and Poci, Dritan},
  issn         = {1522-9645},
  keyword      = {Atrial fibrillation,Mortality,Gender,Age,Long term},
  language     = {eng},
  number       = {14},
  pages        = {1061--1067},
  publisher    = {Oxford University Press},
  series       = {European Heart Journal},
  title        = {All-cause mortality in 272 186 patients hospitalized with incident atrial fibrillation 1995-2008: a Swedish nationwide long-term case-control study},
  url          = {http://dx.doi.org/10.1093/eurheartj/ehs469},
  volume       = {34},
  year         = {2013},
}