The pancreatic β-cell recognition of insulin secretagogues-III. Effects of substituting sulphur for oxygen in the d-glucose molecule
Hellman, Bo ; Lernmark, Åke LU
; Sehlin, Janove
; Täljedal, Inge bert
and Whistler, Roy L.
(1973)
In Biochemical Pharmacology
22(1).
p.29-35
- Abstract
Sulphur-containing analogues of d-glucose were tested for effects on insulin release, d-glucose transport and d-glucose oxidation in microdissected pancreatic islets of obese-hyperglycemic mice. Substituting sulphur for oxygen in the ring structure of d-glucose (5-thio-d-glucose) resulted in a total loss of insulin-releasing ability. 5-Thio-d-glucose inhibited d-glucose-stimulated insulin release, d-glucose oxidation, and to a lesser extent d-glucose transport. Another d-glucose analogue, containing sulphur bound to carbon 1 (1-thio-β-d-glucose) did not influence d-glucose transport or oxidation. Whether 1-thio-β-d-glucose affected insulin release could not be decided because this compound appeared to destroy the insulin molecule. The... (More)
Sulphur-containing analogues of d-glucose were tested for effects on insulin release, d-glucose transport and d-glucose oxidation in microdissected pancreatic islets of obese-hyperglycemic mice. Substituting sulphur for oxygen in the ring structure of d-glucose (5-thio-d-glucose) resulted in a total loss of insulin-releasing ability. 5-Thio-d-glucose inhibited d-glucose-stimulated insulin release, d-glucose oxidation, and to a lesser extent d-glucose transport. Another d-glucose analogue, containing sulphur bound to carbon 1 (1-thio-β-d-glucose) did not influence d-glucose transport or oxidation. Whether 1-thio-β-d-glucose affected insulin release could not be decided because this compound appeared to destroy the insulin molecule. The results are compatible with the hypothesis that D-glucose metabolism plays a role in the recognition of this sugar as an insulin secretagogue.
(Less)
- author
- Hellman, Bo
; Lernmark, Åke
LU
; Sehlin, Janove
; Täljedal, Inge bert
and Whistler, Roy L.
- publishing date
- 1973-01-01
- type
- Contribution to journal
- publication status
- published
- in
- Biochemical Pharmacology
- volume
- 22
- issue
- 1
- pages
- 7 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:4587198
- scopus:0015560085
- ISSN
- 0006-2952
- DOI
- 10.1016/0006-2952(73)90251-7
- language
- English
- LU publication?
- no
- id
- 38cadc86-4cc4-4255-ab7f-193c4618e475
- date added to LUP
- 2019-09-18 12:22:31
- date last changed
- 2024-03-13 08:19:35
@article{38cadc86-4cc4-4255-ab7f-193c4618e475,
abstract = {{<p>Sulphur-containing analogues of d-glucose were tested for effects on insulin release, d-glucose transport and d-glucose oxidation in microdissected pancreatic islets of obese-hyperglycemic mice. Substituting sulphur for oxygen in the ring structure of d-glucose (5-thio-d-glucose) resulted in a total loss of insulin-releasing ability. 5-Thio-d-glucose inhibited d-glucose-stimulated insulin release, d-glucose oxidation, and to a lesser extent d-glucose transport. Another d-glucose analogue, containing sulphur bound to carbon 1 (1-thio-β-d-glucose) did not influence d-glucose transport or oxidation. Whether 1-thio-β-d-glucose affected insulin release could not be decided because this compound appeared to destroy the insulin molecule. The results are compatible with the hypothesis that D-glucose metabolism plays a role in the recognition of this sugar as an insulin secretagogue.</p>}},
author = {{Hellman, Bo and Lernmark, Åke and Sehlin, Janove and Täljedal, Inge bert and Whistler, Roy L.}},
issn = {{0006-2952}},
language = {{eng}},
month = {{01}},
number = {{1}},
pages = {{29--35}},
publisher = {{Elsevier}},
series = {{Biochemical Pharmacology}},
title = {{The pancreatic β-cell recognition of insulin secretagogues-III. Effects of substituting sulphur for oxygen in the d-glucose molecule}},
url = {{http://dx.doi.org/10.1016/0006-2952(73)90251-7}},
doi = {{10.1016/0006-2952(73)90251-7}},
volume = {{22}},
year = {{1973}},
}