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Cardiovascular function in adulthood following intrauterine growth restriction with abnormal fetal blood flow

Bjarnegard, N.; Morsing, Eva LU ; Cinthio, Magnus LU ; Lanne, T. and Brodszki, Jana LU (2013) In Ultrasound in Obstetrics & Gynecology 41(2). p.177-184
Abstract
Objectives To examine whether intrauterine growth restriction (IUGR) is associated with increased cardiovascular risk later in life. Methods We examined 19 young adults (aged 2225 years) who were born at term after IUGR, along with 18 controls. All had been examined previously with fetal Doppler, and in the present follow-up with echocardiography, carotid echo-tracking ultrasound, applanation tonometry, blood pressure and laser Doppler, in order to characterize their cardiac and vascular geometry and/or function. Results The diameter of the ascending aorta and the left ventricular diameter were smaller in the IUGR group, but only ascending aortic diameter remained significantly smaller after adjustment for body surface area (P<0.05).... (More)
Objectives To examine whether intrauterine growth restriction (IUGR) is associated with increased cardiovascular risk later in life. Methods We examined 19 young adults (aged 2225 years) who were born at term after IUGR, along with 18 controls. All had been examined previously with fetal Doppler, and in the present follow-up with echocardiography, carotid echo-tracking ultrasound, applanation tonometry, blood pressure and laser Doppler, in order to characterize their cardiac and vascular geometry and/or function. Results The diameter of the ascending aorta and the left ventricular diameter were smaller in the IUGR group, but only ascending aortic diameter remained significantly smaller after adjustment for body surface area (P<0.05). The aortic pressure augmentation index was higher in the IUGR group (P<0.05). The common carotid artery diameter, intimamedia thickness and distensibility as well as left ventricular mass and function were similar in the two groups. IUGR status was found to be an independent predictor of ascending aortic diameter. Conclusions IUGR due to placental dysfunction seems to contribute to the higher systolic blood pressure augmentation and the smaller aortic dimensions that are observed in adults more than 20 years later, with possible negative consequences for future left ventricular performance due to increased aortic impedance. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aorta, echocardiography, intrauterine growth restriction, pulse wave, analysis, young adulthood
in
Ultrasound in Obstetrics & Gynecology
volume
41
issue
2
pages
177 - 184
publisher
John Wiley & Sons
external identifiers
  • wos:000314473600011
  • scopus:84873375889
ISSN
1469-0705
DOI
10.1002/uog.12314
language
English
LU publication?
yes
id
38e215a5-1c2c-429d-9b86-30439de52e20 (old id 3590001)
date added to LUP
2013-03-20 14:49:14
date last changed
2019-03-10 03:48:17
@article{38e215a5-1c2c-429d-9b86-30439de52e20,
  abstract     = {Objectives To examine whether intrauterine growth restriction (IUGR) is associated with increased cardiovascular risk later in life. Methods We examined 19 young adults (aged 2225 years) who were born at term after IUGR, along with 18 controls. All had been examined previously with fetal Doppler, and in the present follow-up with echocardiography, carotid echo-tracking ultrasound, applanation tonometry, blood pressure and laser Doppler, in order to characterize their cardiac and vascular geometry and/or function. Results The diameter of the ascending aorta and the left ventricular diameter were smaller in the IUGR group, but only ascending aortic diameter remained significantly smaller after adjustment for body surface area (P&lt;0.05). The aortic pressure augmentation index was higher in the IUGR group (P&lt;0.05). The common carotid artery diameter, intimamedia thickness and distensibility as well as left ventricular mass and function were similar in the two groups. IUGR status was found to be an independent predictor of ascending aortic diameter. Conclusions IUGR due to placental dysfunction seems to contribute to the higher systolic blood pressure augmentation and the smaller aortic dimensions that are observed in adults more than 20 years later, with possible negative consequences for future left ventricular performance due to increased aortic impedance.},
  author       = {Bjarnegard, N. and Morsing, Eva and Cinthio, Magnus and Lanne, T. and Brodszki, Jana},
  issn         = {1469-0705},
  keyword      = {aorta,echocardiography,intrauterine growth restriction,pulse wave,analysis,young adulthood},
  language     = {eng},
  number       = {2},
  pages        = {177--184},
  publisher    = {John Wiley & Sons},
  series       = {Ultrasound in Obstetrics & Gynecology},
  title        = {Cardiovascular function in adulthood following intrauterine growth restriction with abnormal fetal blood flow},
  url          = {http://dx.doi.org/10.1002/uog.12314},
  volume       = {41},
  year         = {2013},
}