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A general formalism for metabolic control analysis

Ehlde, M and Zacchi, Guido LU (1997) In Chemical Engineering Science 52(15). p.2599-2606
Abstract
A general formalism for Metabolic Control Analysis is derived using general sensitivity analysis and structural information of the metabolic pathway inherent in the stoichiometry matrix. The equations derived provide a general procedure for calculating the control coefficients from the elasticity coefficients using matrix algebra, and is valid for any pathway stoichiometry. The procedure diminishes the risk of deriving erroneous relations and is, due to its generality, well suited for computer handling. The formalism is mathematically stringent and is a complement to the original theorems of Metabolic Control Analysis, which were derived using ad hoc reasoning. (C) 1997 Elsevier Science Ltd.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemical Engineering Science
volume
52
issue
15
pages
2599 - 2606
publisher
Elsevier
external identifiers
  • wos:A1997XM23200014
  • scopus:0031213577
ISSN
0009-2509
DOI
10.1016/S0009-2509(97)00076-6
language
English
LU publication?
yes
id
778efe70-8136-4100-bda5-c58ec8ff935a (old id 3911478)
date added to LUP
2013-06-28 13:57:03
date last changed
2017-01-01 07:18:48
@article{778efe70-8136-4100-bda5-c58ec8ff935a,
  abstract     = {A general formalism for Metabolic Control Analysis is derived using general sensitivity analysis and structural information of the metabolic pathway inherent in the stoichiometry matrix. The equations derived provide a general procedure for calculating the control coefficients from the elasticity coefficients using matrix algebra, and is valid for any pathway stoichiometry. The procedure diminishes the risk of deriving erroneous relations and is, due to its generality, well suited for computer handling. The formalism is mathematically stringent and is a complement to the original theorems of Metabolic Control Analysis, which were derived using ad hoc reasoning. (C) 1997 Elsevier Science Ltd.},
  author       = {Ehlde, M and Zacchi, Guido},
  issn         = {0009-2509},
  language     = {eng},
  number       = {15},
  pages        = {2599--2606},
  publisher    = {Elsevier},
  series       = {Chemical Engineering Science},
  title        = {A general formalism for metabolic control analysis},
  url          = {http://dx.doi.org/10.1016/S0009-2509(97)00076-6},
  volume       = {52},
  year         = {1997},
}