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Simulation of batch and continuous reactors with co-immobilized yeast and β-galactosidase

Axelsson, Anders LU and Zacchi, Guido LU (1991) In Journal of Chemical Technology and Biotechnology 52(4). p.481-497
Abstract
A reaction-diffusion model was used to simulate a co-immobilized system utilizing the numerical method of orthogonal collocation. The production of ethanol from deproteinized whey using beta-galactosidase co-immobilized with Saccharomyces cerevisiae in calcium alginate gel beads was chosen as a model system. Calculated concentrations of lactose, glucose, galactose and ethanol were compared with experimental data for a batch reactor and a continuous horizontal packed-bed reactor. The mathematical model has been used to analyse the influence of internal and external mass transfer for the continuous reactor. The external mass transfer was shown to be of minor importance. The introduction of baffles decreased the backmixing in the horizontal... (More)
A reaction-diffusion model was used to simulate a co-immobilized system utilizing the numerical method of orthogonal collocation. The production of ethanol from deproteinized whey using beta-galactosidase co-immobilized with Saccharomyces cerevisiae in calcium alginate gel beads was chosen as a model system. Calculated concentrations of lactose, glucose, galactose and ethanol were compared with experimental data for a batch reactor and a continuous horizontal packed-bed reactor. The mathematical model has been used to analyse the influence of internal and external mass transfer for the continuous reactor. The external mass transfer was shown to be of minor importance. The introduction of baffles decreased the backmixing in the horizontal packed-bed reactor. Internal mass transfer was found to be the main cause of the reduction in the apparent reaction rate. Thus, much of the expected increase in reaction rate is diminished by mass transfer hindrance when the cell concentration is increased. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MODELING, COIMMOBILISATION, BIOREACTOR, COLLOCATION, YEAST, BETA-GALACTOSIDASE
in
Journal of Chemical Technology and Biotechnology
volume
52
issue
4
pages
481 - 497
publisher
Wiley-Blackwell
external identifiers
  • wos:A1991GZ88000005
  • scopus:0026331865
ISSN
0268-2575
DOI
10.1002/jctb.280520406
language
English
LU publication?
yes
id
27011e76-e434-4b08-aa51-4bb93ed3ff26 (old id 3911603)
date added to LUP
2013-06-28 10:45:18
date last changed
2017-08-06 04:32:07
@article{27011e76-e434-4b08-aa51-4bb93ed3ff26,
  abstract     = {A reaction-diffusion model was used to simulate a co-immobilized system utilizing the numerical method of orthogonal collocation. The production of ethanol from deproteinized whey using beta-galactosidase co-immobilized with Saccharomyces cerevisiae in calcium alginate gel beads was chosen as a model system. Calculated concentrations of lactose, glucose, galactose and ethanol were compared with experimental data for a batch reactor and a continuous horizontal packed-bed reactor. The mathematical model has been used to analyse the influence of internal and external mass transfer for the continuous reactor. The external mass transfer was shown to be of minor importance. The introduction of baffles decreased the backmixing in the horizontal packed-bed reactor. Internal mass transfer was found to be the main cause of the reduction in the apparent reaction rate. Thus, much of the expected increase in reaction rate is diminished by mass transfer hindrance when the cell concentration is increased.},
  author       = {Axelsson, Anders and Zacchi, Guido},
  issn         = {0268-2575},
  keyword      = {MODELING,COIMMOBILISATION,BIOREACTOR,COLLOCATION,YEAST,BETA-GALACTOSIDASE},
  language     = {eng},
  number       = {4},
  pages        = {481--497},
  publisher    = {Wiley-Blackwell},
  series       = {Journal of Chemical Technology and Biotechnology},
  title        = {Simulation of batch and continuous reactors with co-immobilized yeast and β-galactosidase},
  url          = {http://dx.doi.org/10.1002/jctb.280520406},
  volume       = {52},
  year         = {1991},
}