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Economic evaluation of the hydrolysis of lactose using immobilized beta-galactosidase

Axelsson, Anders LU and Zacchi, Guido LU (1990) In Applied Biochemistry and Biotechnology 24-5. p.679-693
Abstract
A computer program for preliminary cost estimates of free and immobilized enzyme systems has been developed. The cost for the hydrolysis of lactose by β-galactosidase fromAspergillus oryzae has been calculated for a batch tank reactor, with free (BTRF) and immobilized (BTRI) enzymes, a continuously stirred tank reactor (CSTR) and a plug-flow tubular reactor (PFTR), considering the mass transfer behavior and deactivation of the enzyme.



Enzyme immobilization is economically feasible, compared with a system with free enzymes, despite a very high cost for the enzyme attachment. At a half-life time of 80 d, the PFTR gives the lowest cost (0.48 SEK/kg lactose), but the cost for the BTRI is just slightly higher (0.66 SEK/kg... (More)
A computer program for preliminary cost estimates of free and immobilized enzyme systems has been developed. The cost for the hydrolysis of lactose by β-galactosidase fromAspergillus oryzae has been calculated for a batch tank reactor, with free (BTRF) and immobilized (BTRI) enzymes, a continuously stirred tank reactor (CSTR) and a plug-flow tubular reactor (PFTR), considering the mass transfer behavior and deactivation of the enzyme.



Enzyme immobilization is economically feasible, compared with a system with free enzymes, despite a very high cost for the enzyme attachment. At a half-life time of 80 d, the PFTR gives the lowest cost (0.48 SEK/kg lactose), but the cost for the BTRI is just slightly higher (0.66 SEK/kg lactose) and still much lower than the BTRF (2.10 SEK/kg lactose). (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Applied Biochemistry and Biotechnology
volume
24-5
pages
679 - 693
publisher
Humana Press
external identifiers
  • wos:A1990DE57300065
  • scopus:0025157985
ISSN
1559-0291
DOI
10.1007/BF02920288
language
English
LU publication?
yes
id
ca14ae80-96ca-4d91-be08-27dbad7fb3f8 (old id 3911611)
date added to LUP
2016-04-01 11:57:08
date last changed
2021-01-03 08:17:01
@article{ca14ae80-96ca-4d91-be08-27dbad7fb3f8,
  abstract     = {{A computer program for preliminary cost estimates of free and immobilized enzyme systems has been developed. The cost for the hydrolysis of lactose by β-galactosidase fromAspergillus oryzae has been calculated for a batch tank reactor, with free (BTRF) and immobilized (BTRI) enzymes, a continuously stirred tank reactor (CSTR) and a plug-flow tubular reactor (PFTR), considering the mass transfer behavior and deactivation of the enzyme.<br/><br>
<br/><br>
Enzyme immobilization is economically feasible, compared with a system with free enzymes, despite a very high cost for the enzyme attachment. At a half-life time of 80 d, the PFTR gives the lowest cost (0.48 SEK/kg lactose), but the cost for the BTRI is just slightly higher (0.66 SEK/kg lactose) and still much lower than the BTRF (2.10 SEK/kg lactose).}},
  author       = {{Axelsson, Anders and Zacchi, Guido}},
  issn         = {{1559-0291}},
  language     = {{eng}},
  pages        = {{679--693}},
  publisher    = {{Humana Press}},
  series       = {{Applied Biochemistry and Biotechnology}},
  title        = {{Economic evaluation of the hydrolysis of lactose using immobilized beta-galactosidase}},
  url          = {{http://dx.doi.org/10.1007/BF02920288}},
  doi          = {{10.1007/BF02920288}},
  volume       = {{24-5}},
  year         = {{1990}},
}