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Blood pressure and pulse wave velocity as metrics for evaluating pathologic ageing of the cardiovascular system.

Nilsson, Peter LU ; Khalili, Payam LU and Franklin, Stanley S (2014) In Blood Pressure 23(1). p.17-30
Abstract
The influence of chronological ageing on the components of the cardiovascular system is of fundamental importance for understanding how hemodynamics change and the cardiovascular risk increases with age, the most important risk marker. An increase in peripheral vascular resistance associated with increased stiffness of central elastic arteries represents hallmarks of this ageing effect on the vasculature, referred to as early vascular ageing (EVA). In clinical practice, it translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV) - a marker of arterial stiffness. A c-f PWV value ≥ 10 m/s is... (More)
The influence of chronological ageing on the components of the cardiovascular system is of fundamental importance for understanding how hemodynamics change and the cardiovascular risk increases with age, the most important risk marker. An increase in peripheral vascular resistance associated with increased stiffness of central elastic arteries represents hallmarks of this ageing effect on the vasculature, referred to as early vascular ageing (EVA). In clinical practice, it translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV) - a marker of arterial stiffness. A c-f PWV value ≥ 10 m/s is threshold for increased risk according. Improved lifestyle and control of risk factors via appropriate drug therapy are of importance in providing vascular protection related to EVA. One target group might be members of risk families including subjects with early onset cardiovascular disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood Pressure
volume
23
issue
1
pages
17 - 30
publisher
Taylor & Francis
external identifiers
  • pmid:23750722
  • wos:000331906400003
  • scopus:84896704994
ISSN
0803-7051
DOI
10.3109/08037051.2013.796142
language
English
LU publication?
yes
id
e09a7682-65ff-4718-bcd3-fab0ff49c959 (old id 3913552)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23750722?dopt=Abstract
date added to LUP
2013-07-01 12:07:10
date last changed
2017-10-22 03:21:44
@article{e09a7682-65ff-4718-bcd3-fab0ff49c959,
  abstract     = {The influence of chronological ageing on the components of the cardiovascular system is of fundamental importance for understanding how hemodynamics change and the cardiovascular risk increases with age, the most important risk marker. An increase in peripheral vascular resistance associated with increased stiffness of central elastic arteries represents hallmarks of this ageing effect on the vasculature, referred to as early vascular ageing (EVA). In clinical practice, it translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV) - a marker of arterial stiffness. A c-f PWV value ≥ 10 m/s is threshold for increased risk according. Improved lifestyle and control of risk factors via appropriate drug therapy are of importance in providing vascular protection related to EVA. One target group might be members of risk families including subjects with early onset cardiovascular disease.},
  author       = {Nilsson, Peter and Khalili, Payam and Franklin, Stanley S},
  issn         = {0803-7051},
  language     = {eng},
  number       = {1},
  pages        = {17--30},
  publisher    = {Taylor & Francis},
  series       = {Blood Pressure},
  title        = {Blood pressure and pulse wave velocity as metrics for evaluating pathologic ageing of the cardiovascular system.},
  url          = {http://dx.doi.org/10.3109/08037051.2013.796142},
  volume       = {23},
  year         = {2014},
}