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Comparison of different flowability tests for powders for inhalation

Thalberg, K; Lindholm, D and Axelsson, Anders LU (2004) In Powder Technology 146(3). p.206-213
Abstract
A series of placebo powders for inhalation was characterized regarding bulk density and powder flowability using different techniques. The powders were of the ordered mixture type and were prepared by mixing a pharmaceutical carrier grade of lactose with different fractions of intermediate sized and fine (i.e., micronized) lactose. A modified Hausner Ratio was obtained by measurement of the poured and the compressed bulk densities. Other tests investigated were the angle of repose, the avalanching behaviour using the AeroFlow, and the yield strength using the Uniaxial tester. Furthermore, the relation between ordered mixture composition and flowability was examined. Of the methods investigated, the modified Hausner Ratio discriminates well... (More)
A series of placebo powders for inhalation was characterized regarding bulk density and powder flowability using different techniques. The powders were of the ordered mixture type and were prepared by mixing a pharmaceutical carrier grade of lactose with different fractions of intermediate sized and fine (i.e., micronized) lactose. A modified Hausner Ratio was obtained by measurement of the poured and the compressed bulk densities. Other tests investigated were the angle of repose, the avalanching behaviour using the AeroFlow, and the yield strength using the Uniaxial tester. Furthermore, the relation between ordered mixture composition and flowability was examined. Of the methods investigated, the modified Hausner Ratio discriminates well between the investigated powders and seems to have the widest measuring range. It was also found that the poured and compressed bulk densities provide information about the packing of the particles in the powders. A good correlation was obtained between the modified Hausner Ratio and the angle of repose. The AeroFlow was suitable for powders with a low percentage of fine particles, but could not discriminate between the more cohesive powders. The Uniaxial tester, on the other hand, seems to be better suited for more cohesive powders. Regarding the powder composition, addition of micronized particles has a strong influence on the flowability of ordered mixtures, while intermediate sized particles have little impact on the powder flow. (C) 2004 Elsevier B.V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
AeroFlow, angle of repose, flowability, hausner ratio, ordered mixture, uniaxial tester
in
Powder Technology
volume
146
issue
3
pages
206 - 213
publisher
Elsevier
external identifiers
  • wos:000225173700006
  • scopus:7044226457
ISSN
0032-5910
DOI
10.1016/j.powtec.2004.08.003
language
English
LU publication?
yes
id
cdda1481-3404-4f2e-b1cc-3bf4e2c618eb (old id 3918133)
date added to LUP
2013-07-05 08:52:35
date last changed
2017-10-01 04:37:30
@article{cdda1481-3404-4f2e-b1cc-3bf4e2c618eb,
  abstract     = {A series of placebo powders for inhalation was characterized regarding bulk density and powder flowability using different techniques. The powders were of the ordered mixture type and were prepared by mixing a pharmaceutical carrier grade of lactose with different fractions of intermediate sized and fine (i.e., micronized) lactose. A modified Hausner Ratio was obtained by measurement of the poured and the compressed bulk densities. Other tests investigated were the angle of repose, the avalanching behaviour using the AeroFlow, and the yield strength using the Uniaxial tester. Furthermore, the relation between ordered mixture composition and flowability was examined. Of the methods investigated, the modified Hausner Ratio discriminates well between the investigated powders and seems to have the widest measuring range. It was also found that the poured and compressed bulk densities provide information about the packing of the particles in the powders. A good correlation was obtained between the modified Hausner Ratio and the angle of repose. The AeroFlow was suitable for powders with a low percentage of fine particles, but could not discriminate between the more cohesive powders. The Uniaxial tester, on the other hand, seems to be better suited for more cohesive powders. Regarding the powder composition, addition of micronized particles has a strong influence on the flowability of ordered mixtures, while intermediate sized particles have little impact on the powder flow. (C) 2004 Elsevier B.V. All rights reserved.},
  author       = {Thalberg, K and Lindholm, D and Axelsson, Anders},
  issn         = {0032-5910},
  keyword      = {AeroFlow,angle of repose,flowability,hausner ratio,ordered mixture,uniaxial tester},
  language     = {eng},
  number       = {3},
  pages        = {206--213},
  publisher    = {Elsevier},
  series       = {Powder Technology},
  title        = {Comparison of different flowability tests for powders for inhalation},
  url          = {http://dx.doi.org/10.1016/j.powtec.2004.08.003},
  volume       = {146},
  year         = {2004},
}