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Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis: Data From a European Prospective Cohort Study (The IBD in EPIC Study)

Chan, Simon S. M.; Luben, Robert; Olsen, Anja; Tjonneland, Anne; Kaaks, Rudolf; Teucher, Birgit; Lindgren, Stefan LU ; Grip, Olof LU ; Key, Timothy and Crowe, Francesca L., et al. (2013) In American Journal of Gastroenterology 108(4). p.575-582
Abstract
OBJECTIVES: Obesity is associated with a proinflammatory state that may be involved in the etiology of inflammatory bowel disease (IBD), for which there are plausible biological mechanisms. Our aim was to perform the first prospective cohort study investigating if there is an association between obesity and the development of incident IBD. METHODS: A total of 300,724 participants were recruited into the European Prospective Investigation into Cancer and Nutrition study. At recruitment, anthropometric measurements of height and weight plus physical activity and total energy intake from validated questionnaires were recorded. The cohort was monitored identifying participants who developed either Crohn's disease (CD) or ulcerative colitis... (More)
OBJECTIVES: Obesity is associated with a proinflammatory state that may be involved in the etiology of inflammatory bowel disease (IBD), for which there are plausible biological mechanisms. Our aim was to perform the first prospective cohort study investigating if there is an association between obesity and the development of incident IBD. METHODS: A total of 300,724 participants were recruited into the European Prospective Investigation into Cancer and Nutrition study. At recruitment, anthropometric measurements of height and weight plus physical activity and total energy intake from validated questionnaires were recorded. The cohort was monitored identifying participants who developed either Crohn's disease (CD) or ulcerative colitis (UC). Each case was matched with four controls and conditional logistic regression used to calculate odds ratios (ORs) for body mass index (BMI) adjusted for smoking, energy intake, and physical activity. RESULTS: In the cohort, 177 participants developed incident UC and 75 participants developed incident CD. There were no associations with the four higher categories of BMI compared with a normal BMI for UC (P-trend = 0.36) or CD (P-trend = 0.83). The lack of associations was consistent when BMI was analyzed as a continuous or binary variable (BMI 18.5 <25.0 vs. >= 25 kg/m(2)). Physical activity and total energy intake, factors that influence BMI, did not show any association with UC (physical activity, P-trend = 0.79; total energy intake, P-trend = 0.18) or CD (physical activity, P-trend = 0.42; total energy, P-trend = 0.11). CONCLUSIONS: Obesity as measured by BMI is not associated with the development of incident UC or CD. Alternative measures of obesity are required to further investigate the role of obesity in the development of incident IBD. (Less)
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Contribution to journal
publication status
published
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in
American Journal of Gastroenterology
volume
108
issue
4
pages
575 - 582
publisher
Wiley-Blackwell
external identifiers
  • wos:000318703300014
  • scopus:84875918270
ISSN
1572-0241
DOI
10.1038/ajg.2012.453
language
English
LU publication?
yes
id
5071a4da-9b58-43b1-9017-2f9ff0b8da9b (old id 3935561)
date added to LUP
2013-08-01 07:41:54
date last changed
2019-09-15 03:03:09
@article{5071a4da-9b58-43b1-9017-2f9ff0b8da9b,
  abstract     = {OBJECTIVES: Obesity is associated with a proinflammatory state that may be involved in the etiology of inflammatory bowel disease (IBD), for which there are plausible biological mechanisms. Our aim was to perform the first prospective cohort study investigating if there is an association between obesity and the development of incident IBD. METHODS: A total of 300,724 participants were recruited into the European Prospective Investigation into Cancer and Nutrition study. At recruitment, anthropometric measurements of height and weight plus physical activity and total energy intake from validated questionnaires were recorded. The cohort was monitored identifying participants who developed either Crohn's disease (CD) or ulcerative colitis (UC). Each case was matched with four controls and conditional logistic regression used to calculate odds ratios (ORs) for body mass index (BMI) adjusted for smoking, energy intake, and physical activity. RESULTS: In the cohort, 177 participants developed incident UC and 75 participants developed incident CD. There were no associations with the four higher categories of BMI compared with a normal BMI for UC (P-trend = 0.36) or CD (P-trend = 0.83). The lack of associations was consistent when BMI was analyzed as a continuous or binary variable (BMI 18.5 &lt;25.0 vs. &gt;= 25 kg/m(2)). Physical activity and total energy intake, factors that influence BMI, did not show any association with UC (physical activity, P-trend = 0.79; total energy intake, P-trend = 0.18) or CD (physical activity, P-trend = 0.42; total energy, P-trend = 0.11). CONCLUSIONS: Obesity as measured by BMI is not associated with the development of incident UC or CD. Alternative measures of obesity are required to further investigate the role of obesity in the development of incident IBD.},
  author       = {Chan, Simon S. M. and Luben, Robert and Olsen, Anja and Tjonneland, Anne and Kaaks, Rudolf and Teucher, Birgit and Lindgren, Stefan and Grip, Olof and Key, Timothy and Crowe, Francesca L. and Bergmann, Manuela M. and Boeing, Heiner and Hallmans, Goran and Karling, Pontus and Overvad, Kim and Palli, Domenico and Masala, Giovanna and Kennedy, Hugh and vanSchaik, Fiona and Bueno-de-Mesquita, Bas and Oldenburg, Bas and Khaw, Kay-Tee and Riboli, Elio and Hart, Andrew R.},
  issn         = {1572-0241},
  language     = {eng},
  number       = {4},
  pages        = {575--582},
  publisher    = {Wiley-Blackwell},
  series       = {American Journal of Gastroenterology},
  title        = {Body Mass Index and the Risk for Crohn's Disease and Ulcerative Colitis: Data From a European Prospective Cohort Study (The IBD in EPIC Study)},
  url          = {http://dx.doi.org/10.1038/ajg.2012.453},
  volume       = {108},
  year         = {2013},
}