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A case of facial cellulitis and necrotizing lymphadenitis due to cowpox virus infection

Pahlitzsch, Roland ; Hammarin, Anna-Lena and Widell, Anders LU (2006) In Clinical Infectious Diseases 43(6). p.737-742
Abstract
We describe a patient with facial cellulitis/erysipelas due to cowpox virus inoculation in the respiratory epithelium of the nose. A cytopathic agent was isolated in cell culture, and the diagnosis of cowpox was confirmed by electron microscopy and polymerase chain reaction. The most likely source of infection was exposure to the family cats. In addition to the severe edematous cellulitis of the face, the clinical course was dominated by several areas of subcutaneous, necrotizing lymphadenitis, from one of which a huge abscess formed that had to be incised. Hyperbaric oxygen treatment was provided to prevent development of dermal necrosis. The healing process in the numerous areas of lymphadenitis was markedly protracted, and 1 persisting... (More)
We describe a patient with facial cellulitis/erysipelas due to cowpox virus inoculation in the respiratory epithelium of the nose. A cytopathic agent was isolated in cell culture, and the diagnosis of cowpox was confirmed by electron microscopy and polymerase chain reaction. The most likely source of infection was exposure to the family cats. In addition to the severe edematous cellulitis of the face, the clinical course was dominated by several areas of subcutaneous, necrotizing lymphadenitis, from one of which a huge abscess formed that had to be incised. Hyperbaric oxygen treatment was provided to prevent development of dermal necrosis. The healing process in the numerous areas of lymphadenitis was markedly protracted, and 1 persisting node ( which yielded positive results on polymerase chain reaction) had to be excised 2 years after onset of disease. This is the first reported case of inoculation of cowpox virus in the respiratory mucosa of the nose. It resulted in a clinical course totally different than that for inoculation in the skin. We also present a short review of findings on orthopoxvirus infection that focuses on the chain of transmission. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical Infectious Diseases
volume
43
issue
6
pages
737 - 742
publisher
Oxford University Press
external identifiers
  • pmid:16912948
  • wos:000240050000012
  • scopus:33748313082
ISSN
1537-6591
language
English
LU publication?
yes
id
8dbc5bf0-f056-45ef-a348-e8ba885feb77 (old id 395276)
alternative location
http://www.journals.uchicago.edu/CID/journal/issues/v43n6/39453/brief/39453.abstract.html
date added to LUP
2016-04-01 11:52:19
date last changed
2020-12-08 01:16:48
@article{8dbc5bf0-f056-45ef-a348-e8ba885feb77,
  abstract     = {We describe a patient with facial cellulitis/erysipelas due to cowpox virus inoculation in the respiratory epithelium of the nose. A cytopathic agent was isolated in cell culture, and the diagnosis of cowpox was confirmed by electron microscopy and polymerase chain reaction. The most likely source of infection was exposure to the family cats. In addition to the severe edematous cellulitis of the face, the clinical course was dominated by several areas of subcutaneous, necrotizing lymphadenitis, from one of which a huge abscess formed that had to be incised. Hyperbaric oxygen treatment was provided to prevent development of dermal necrosis. The healing process in the numerous areas of lymphadenitis was markedly protracted, and 1 persisting node ( which yielded positive results on polymerase chain reaction) had to be excised 2 years after onset of disease. This is the first reported case of inoculation of cowpox virus in the respiratory mucosa of the nose. It resulted in a clinical course totally different than that for inoculation in the skin. We also present a short review of findings on orthopoxvirus infection that focuses on the chain of transmission.},
  author       = {Pahlitzsch, Roland and Hammarin, Anna-Lena and Widell, Anders},
  issn         = {1537-6591},
  language     = {eng},
  number       = {6},
  pages        = {737--742},
  publisher    = {Oxford University Press},
  series       = {Clinical Infectious Diseases},
  title        = {A case of facial cellulitis and necrotizing lymphadenitis due to cowpox virus infection},
  url          = {http://www.journals.uchicago.edu/CID/journal/issues/v43n6/39453/brief/39453.abstract.html},
  volume       = {43},
  year         = {2006},
}