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High frequency of primary hyperaldosteronism among hypertensive patients from a primary care area in Sweden

Westerdahl, Christina LU ; Bergenfelz, Anders LU ; Isaksson, Anders LU ; Wihl, Anders ; Nerbrand, Christina LU and Valdemarsson, Stig LU (2006) In Scandinavian Journal of Primary Health Care 24(3). p.154-159
Abstract
Objective. To search for primary hyperaldosteronism (PHA) among previously known hypertensive patients in primary care, using the aldosterone/renin ratio (ARR), and to evaluate clinical and biochemical characteristics in patients with high or normal ratio. Design. Patient survey study. Setting and subjects. The study population was recruited by written invitation among hypertensive patients in two primary care areas in Sweden. A total of 200 patients met the criteria and were included in the study. Main outcome measures. The ARR was calculated from serum aldosterone and plasma renin concentrations. The cut-off level for ARR was set to 100, as confirmed in 28 healthy subjects. Patients with increased ARR were considered for a confirmatory... (More)
Objective. To search for primary hyperaldosteronism (PHA) among previously known hypertensive patients in primary care, using the aldosterone/renin ratio (ARR), and to evaluate clinical and biochemical characteristics in patients with high or normal ratio. Design. Patient survey study. Setting and subjects. The study population was recruited by written invitation among hypertensive patients in two primary care areas in Sweden. A total of 200 patients met the criteria and were included in the study. Main outcome measures. The ARR was calculated from serum aldosterone and plasma renin concentrations. The cut-off level for ARR was set to 100, as confirmed in 28 healthy subjects. Patients with increased ARR were considered for a confirmatory test, using the fludrocortisone suppression test. Results. Of 200 patients, 50 patients had ARR >100; 26 patients were further evaluated by fludrocortisone suppression test. Seventeen of these patients had an incomplete aldosterone inhibition. Conclusion. In total 17 of 200 evaluated patients (8.5%) had an incomplete suppression with fludrocortisone. This confirms previous reports on a high frequency of PHA. No significant biochemical or clinical differences were found among hypertensive patients with PHA compared with the whole sample. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
primary hyperaldosteronism, hypertension, family practice, aldosterone, aldosterone to renin ratio, renin
in
Scandinavian Journal of Primary Health Care
volume
24
issue
3
pages
154 - 159
publisher
Taylor & Francis
external identifiers
  • wos:000239949500006
  • pmid:16923624
  • scopus:33747708226
  • pmid:16923624
ISSN
0281-3432
DOI
10.1080/02813430600830931
language
English
LU publication?
yes
id
3e2df7b4-7cc8-4bcc-990d-c82033465ccf (old id 395433)
date added to LUP
2016-04-01 11:43:26
date last changed
2021-08-25 01:23:17
@article{3e2df7b4-7cc8-4bcc-990d-c82033465ccf,
  abstract     = {Objective. To search for primary hyperaldosteronism (PHA) among previously known hypertensive patients in primary care, using the aldosterone/renin ratio (ARR), and to evaluate clinical and biochemical characteristics in patients with high or normal ratio. Design. Patient survey study. Setting and subjects. The study population was recruited by written invitation among hypertensive patients in two primary care areas in Sweden. A total of 200 patients met the criteria and were included in the study. Main outcome measures. The ARR was calculated from serum aldosterone and plasma renin concentrations. The cut-off level for ARR was set to 100, as confirmed in 28 healthy subjects. Patients with increased ARR were considered for a confirmatory test, using the fludrocortisone suppression test. Results. Of 200 patients, 50 patients had ARR >100; 26 patients were further evaluated by fludrocortisone suppression test. Seventeen of these patients had an incomplete aldosterone inhibition. Conclusion. In total 17 of 200 evaluated patients (8.5%) had an incomplete suppression with fludrocortisone. This confirms previous reports on a high frequency of PHA. No significant biochemical or clinical differences were found among hypertensive patients with PHA compared with the whole sample.},
  author       = {Westerdahl, Christina and Bergenfelz, Anders and Isaksson, Anders and Wihl, Anders and Nerbrand, Christina and Valdemarsson, Stig},
  issn         = {0281-3432},
  language     = {eng},
  number       = {3},
  pages        = {154--159},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Journal of Primary Health Care},
  title        = {High frequency of primary hyperaldosteronism among hypertensive patients from a primary care area in Sweden},
  url          = {http://dx.doi.org/10.1080/02813430600830931},
  doi          = {10.1080/02813430600830931},
  volume       = {24},
  year         = {2006},
}