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MicroRNAs as Neuronal Fate Determinants.

Åkerblom, Malin LU and Jakobsson, Johan LU (2014) In Neuroscientist 20(3). p.235-242
Abstract
Since the discovery of short, regulatory microRNAs (miRNA) 20 years ago, the understanding of their impact on gene regulation has dramatically increased. Differentiation of cells requires comprehensive changes in regulatory networks at all levels of gene expression. Posttranscriptional regulation by miRNA leads to rapid modifications in the protein level of large gene networks, and it is therefore not surprising that miRNAs have been found to influence the fate of differentiating cells. Several recent studies have shown that overexpression of a single miRNA in different cellular contexts results in forced differentiation of nerve cells. Loss of this miRNA constrains neurogenesis and promotes gliogenesis. This miRNA, miR-124, is probably... (More)
Since the discovery of short, regulatory microRNAs (miRNA) 20 years ago, the understanding of their impact on gene regulation has dramatically increased. Differentiation of cells requires comprehensive changes in regulatory networks at all levels of gene expression. Posttranscriptional regulation by miRNA leads to rapid modifications in the protein level of large gene networks, and it is therefore not surprising that miRNAs have been found to influence the fate of differentiating cells. Several recent studies have shown that overexpression of a single miRNA in different cellular contexts results in forced differentiation of nerve cells. Loss of this miRNA constrains neurogenesis and promotes gliogenesis. This miRNA, miR-124, is probably the most well-documented example of a miRNA that controls nerve cell fate determination. In this review we summarize the recent findings on miR-124, potential molecular mechanisms used by miR-124 to drive neuronal differentiation, and outline future directions. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Neuroscientist
volume
20
issue
3
pages
235 - 242
publisher
SAGE Publications Inc.
external identifiers
  • pmid:23877999
  • wos:000336265200009
  • scopus:84900852879
ISSN
1089-4098
DOI
10.1177/1073858413497265
language
English
LU publication?
yes
id
ae99faf6-6920-432a-820e-123aefe55c44 (old id 3955674)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23877999?dopt=Abstract
date added to LUP
2013-08-02 14:12:04
date last changed
2017-09-24 03:06:31
@article{ae99faf6-6920-432a-820e-123aefe55c44,
  abstract     = {Since the discovery of short, regulatory microRNAs (miRNA) 20 years ago, the understanding of their impact on gene regulation has dramatically increased. Differentiation of cells requires comprehensive changes in regulatory networks at all levels of gene expression. Posttranscriptional regulation by miRNA leads to rapid modifications in the protein level of large gene networks, and it is therefore not surprising that miRNAs have been found to influence the fate of differentiating cells. Several recent studies have shown that overexpression of a single miRNA in different cellular contexts results in forced differentiation of nerve cells. Loss of this miRNA constrains neurogenesis and promotes gliogenesis. This miRNA, miR-124, is probably the most well-documented example of a miRNA that controls nerve cell fate determination. In this review we summarize the recent findings on miR-124, potential molecular mechanisms used by miR-124 to drive neuronal differentiation, and outline future directions.},
  author       = {Åkerblom, Malin and Jakobsson, Johan},
  issn         = {1089-4098},
  language     = {eng},
  number       = {3},
  pages        = {235--242},
  publisher    = {SAGE Publications Inc.},
  series       = {Neuroscientist},
  title        = {MicroRNAs as Neuronal Fate Determinants.},
  url          = {http://dx.doi.org/10.1177/1073858413497265},
  volume       = {20},
  year         = {2014},
}