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Factors associated with lifetime risk of open-angle glaucoma blindness.

Peters, Dorothea LU ; Bengtsson, Boel LU and Heijl, Anders LU (2014) In Acta Ophthalmologica 92(5). p.421-425
Abstract
Purpose: To investigate factors associated with bilateral glaucoma blindness, particularly factors available at the time of diagnosis. Methods: Retrospective chart review of all patients with primary open-angle glaucoma (POAG) or pseudoexfoliative glaucoma (PEXG) followed at the Department of Ophthalmology or Low Vision Center of Skåne University Hospital, Malmö, Sweden, who died between January 2006 and June 2010. Disease stage at diagnosis was defined by a simplified version of Mills' glaucoma staging system using perimetric mean deviation (MD) to define six stages of severity. Blindness was defined according to WHO criteria. We used logistic regression analysis to examine the association between risk factors and glaucoma blindness.... (More)
Purpose: To investigate factors associated with bilateral glaucoma blindness, particularly factors available at the time of diagnosis. Methods: Retrospective chart review of all patients with primary open-angle glaucoma (POAG) or pseudoexfoliative glaucoma (PEXG) followed at the Department of Ophthalmology or Low Vision Center of Skåne University Hospital, Malmö, Sweden, who died between January 2006 and June 2010. Disease stage at diagnosis was defined by a simplified version of Mills' glaucoma staging system using perimetric mean deviation (MD) to define six stages of severity. Blindness was defined according to WHO criteria. We used logistic regression analysis to examine the association between risk factors and glaucoma blindness. Results: Four hundred and 23 patients were included; 60% POAG and 40% PEXG. Sixty-four patients (15%) became blind from glaucoma. Blind patients had significantly longer mean duration with diagnosed disease than patients who did not go blind (14.8 years ± 5.8 versus 10.6 years ± 6.5, p < 0.001). The risk of blindness increased with higher intraocular pressure (IOP) (OR 1.08, 95% CI 1.03-1.13) and with each stage of more advanced field loss at time of diagnosis (OR 1.80 95% CI 1.34-2.41). Older age at death was also associated with an increased risk of blindness (OR 1.09 95% CI 1.03-1.14), while age at diagnosis was unimportant. PEXG was not an independent risk factor for blindness. Conclusions: Higher IOP and worse visual field status at baseline were important risk factors, as was older age at death. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Ophthalmologica
volume
92
issue
5
pages
421 - 425
publisher
Wiley-Blackwell
external identifiers
  • pmid:23837818
  • wos:000339482700028
  • scopus:84904719299
ISSN
1755-3768
DOI
10.1111/aos.12203
language
English
LU publication?
yes
id
53685e99-93f8-41f9-84c9-bb63cc05cdf9 (old id 3956059)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23837818?dopt=Abstract
date added to LUP
2013-08-02 11:26:44
date last changed
2017-09-17 03:04:26
@article{53685e99-93f8-41f9-84c9-bb63cc05cdf9,
  abstract     = {Purpose: To investigate factors associated with bilateral glaucoma blindness, particularly factors available at the time of diagnosis. Methods: Retrospective chart review of all patients with primary open-angle glaucoma (POAG) or pseudoexfoliative glaucoma (PEXG) followed at the Department of Ophthalmology or Low Vision Center of Skåne University Hospital, Malmö, Sweden, who died between January 2006 and June 2010. Disease stage at diagnosis was defined by a simplified version of Mills' glaucoma staging system using perimetric mean deviation (MD) to define six stages of severity. Blindness was defined according to WHO criteria. We used logistic regression analysis to examine the association between risk factors and glaucoma blindness. Results: Four hundred and 23 patients were included; 60% POAG and 40% PEXG. Sixty-four patients (15%) became blind from glaucoma. Blind patients had significantly longer mean duration with diagnosed disease than patients who did not go blind (14.8 years ± 5.8 versus 10.6 years ± 6.5, p &lt; 0.001). The risk of blindness increased with higher intraocular pressure (IOP) (OR 1.08, 95% CI 1.03-1.13) and with each stage of more advanced field loss at time of diagnosis (OR 1.80 95% CI 1.34-2.41). Older age at death was also associated with an increased risk of blindness (OR 1.09 95% CI 1.03-1.14), while age at diagnosis was unimportant. PEXG was not an independent risk factor for blindness. Conclusions: Higher IOP and worse visual field status at baseline were important risk factors, as was older age at death.},
  author       = {Peters, Dorothea and Bengtsson, Boel and Heijl, Anders},
  issn         = {1755-3768},
  language     = {eng},
  number       = {5},
  pages        = {421--425},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica},
  title        = {Factors associated with lifetime risk of open-angle glaucoma blindness.},
  url          = {http://dx.doi.org/10.1111/aos.12203},
  volume       = {92},
  year         = {2014},
}