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Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20

Ulvsbäck, M. ; Lazure, C. ; Lilja, Hans LU orcid ; Spurr, N. K. ; Rao, V. V. ; Loffler, C. ; Hansmann, I. and Lundwall, Åke LU (1992) In Journal of Biological Chemistry 267(25). p.4-18080
Abstract
The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage lambda, encompassing 31.5 kilobases (kb) of genomic DNA. The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3'-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.
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organization
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Contribution to journal
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published
subject
keywords
Molecular Sequence Data, Male, Humans, Gonadal Steroid Hormones/*genetics, DNA/genetics/isolation & purification, Codon/genetics, Molecular, Cloning, Pair 20, Human, *Chromosomes, Chromosome Mapping, Chromosome Banding, Southern, Blotting, Amino Acid Sequence, Base Sequence, *Multigene Family, Oligodeoxyribonucleotides, Research Support, Non-U.S. Gov't, Restriction Mapping, Semen/*physiology, *Seminal Vesicle Secretory Proteins, Spermatozoa/*physiology
in
Journal of Biological Chemistry
volume
267
issue
25
pages
4 - 18080
publisher
American Society for Biochemistry and Molecular Biology
external identifiers
  • scopus:0026662010
ISSN
0021-9258
language
English
LU publication?
yes
additional info
25
id
4b793ea3-1803-4da9-b492-ba4739042d68 (old id 3965213)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1517240
date added to LUP
2016-04-04 14:37:49
date last changed
2021-01-03 05:25:20
@article{4b793ea3-1803-4da9-b492-ba4739042d68,
  abstract     = {{The genes for semenogelin I and II, the major protein constituents of the human seminal fluid, have been characterized by three overlapping clones in bacteriophage lambda, encompassing 31.5 kilobases (kb) of genomic DNA. The two genes are located 11.5 kb apart in the region q12-q13.1 on chromosome 20. Both genes are relatively compact, spanning only 2.7 and 3.1 kb, respectively. The transcription units are composed of three exons, of which the first encodes the signal peptide, the second encodes the secreted protein, while the third solely contains 3'-noncoding nucleotides. The nucleotide sequences exhibit a similarity of close to 90% in the exons and exceeding 80% in the introns and flanking nucleotides.}},
  author       = {{Ulvsbäck, M. and Lazure, C. and Lilja, Hans and Spurr, N. K. and Rao, V. V. and Loffler, C. and Hansmann, I. and Lundwall, Åke}},
  issn         = {{0021-9258}},
  keywords     = {{Molecular Sequence Data; Male; Humans; Gonadal Steroid Hormones/*genetics; DNA/genetics/isolation & purification; Codon/genetics; Molecular; Cloning; Pair 20; Human; *Chromosomes; Chromosome Mapping; Chromosome Banding; Southern; Blotting; Amino Acid Sequence; Base Sequence; *Multigene Family; Oligodeoxyribonucleotides; Research Support; Non-U.S. Gov't; Restriction Mapping; Semen/*physiology; *Seminal Vesicle Secretory Proteins; Spermatozoa/*physiology}},
  language     = {{eng}},
  number       = {{25}},
  pages        = {{4--18080}},
  publisher    = {{American Society for Biochemistry and Molecular Biology}},
  series       = {{Journal of Biological Chemistry}},
  title        = {{Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20}},
  url          = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=1517240}},
  volume       = {{267}},
  year         = {{1992}},
}