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A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon

Lundwall, Åke LU and Lazure, C. (1995) In FEBS Lett 374(1). p.6-53
Abstract
Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.
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organization
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Contribution to journal
publication status
published
subject
keywords
*Prostatic Secretory Proteins, *Multigene Family, Molecular Sequence Data, Male, Humans, Guinea Pigs, Gonadal Steroid Hormones/genetics, *Exons, Molecular, *Evolution, Dna, Conserved Sequence, Animals, Base Sequence, Proteins/*genetics, Rats, Research Support, Non-U.S. Gov't, *Semen, Seminal Plasma Proteins, Seminal Vesicle Secretory Proteins, Sequence Homology, Nucleic Acid
in
FEBS Lett
volume
374
issue
1
pages
6 - 53
publisher
Wiley-Blackwell
external identifiers
  • scopus:0028788899
language
English
LU publication?
yes
id
1a4a9e65-0dda-4fbb-8639-401772da7f90 (old id 3965233)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=7589511
date added to LUP
2013-08-11 14:23:34
date last changed
2017-01-01 08:10:00
@article{1a4a9e65-0dda-4fbb-8639-401772da7f90,
  abstract     = {Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.},
  author       = {Lundwall, Åke and Lazure, C.},
  keyword      = {*Prostatic Secretory Proteins,*Multigene Family,Molecular Sequence Data,Male,Humans,Guinea Pigs,Gonadal Steroid Hormones/genetics,*Exons,Molecular,*Evolution,Dna,Conserved Sequence,Animals,Base Sequence,Proteins/*genetics,Rats,Research Support,Non-U.S. Gov't,*Semen,Seminal Plasma Proteins,Seminal Vesicle Secretory Proteins,Sequence Homology,Nucleic Acid},
  language     = {eng},
  number       = {1},
  pages        = {6--53},
  publisher    = {Wiley-Blackwell},
  series       = {FEBS Lett},
  title        = {A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon},
  volume       = {374},
  year         = {1995},
}