Vaginal and urine self-sampling compared to cervical sampling for HPV-testing with the cobas 4800 HPV test
(2017) In Anticancer research 37(8). p.4183-4187- Abstract
Background/Aim: To compare human papillomavirus (HPV) DNA detection in self-collected vaginal and urine samples with clinician-taken cervical samples in relation to histology. Materials and Methods: Self-collected vaginal, urine and clinician-taken cervical samples were analyzed from 218 women with the Cobas 4800 HPV test (Roche Molecular Diagnostics). Results: The sensitivity for detection of HPV in the vaginal self-sampling test was 96.4% and in urine was 83.9% relative to detection by clinician-taken cervical sample. The vaginal self-sampling and the clinician-taken HPV tests had the same sensitivity of 92.8% (95% confidence interval=86.3-96.8%) and specificity for detection of high-grade squamous intraepithelial lesion (HSIL) and... (More)
Background/Aim: To compare human papillomavirus (HPV) DNA detection in self-collected vaginal and urine samples with clinician-taken cervical samples in relation to histology. Materials and Methods: Self-collected vaginal, urine and clinician-taken cervical samples were analyzed from 218 women with the Cobas 4800 HPV test (Roche Molecular Diagnostics). Results: The sensitivity for detection of HPV in the vaginal self-sampling test was 96.4% and in urine was 83.9% relative to detection by clinician-taken cervical sample. The vaginal self-sampling and the clinician-taken HPV tests had the same sensitivity of 92.8% (95% confidence interval=86.3-96.8%) and specificity for detection of high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS). Detection in urine samples had a sensitivity of 76.3% (95% confidence interval=67.9-84.2%) for HSIL/AIS. Conclusion: The Cobas 4800 HPV test detects high-grade pre-cancerous cervical lesions in self-collected vaginal samples with the same high sensitivity as in clinician-taken cervical samples.
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- author
- Asciutto, Katrin Christine LU ; Henningsson, Anna J ; Borgfeldt, Henrik ; Darlin, Lotten LU and Borgfeldt, Christer LU
- organization
- publishing date
- 2017-08-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cytology, HPV analysis, Self-collected vaginal smear, Vaginal smear
- in
- Anticancer research
- volume
- 37
- issue
- 8
- pages
- 5 pages
- publisher
- International Institute of Cancer Research
- external identifiers
-
- pmid:28739704
- wos:000412579000025
- scopus:85026256356
- ISSN
- 0250-7005
- DOI
- 10.21873/anticanres.11807
- language
- English
- LU publication?
- yes
- id
- 39678402-e031-4552-bbfc-cf8bbcd2b578
- date added to LUP
- 2017-08-22 11:14:24
- date last changed
- 2025-01-07 19:05:22
@article{39678402-e031-4552-bbfc-cf8bbcd2b578, abstract = {{<p>Background/Aim: To compare human papillomavirus (HPV) DNA detection in self-collected vaginal and urine samples with clinician-taken cervical samples in relation to histology. Materials and Methods: Self-collected vaginal, urine and clinician-taken cervical samples were analyzed from 218 women with the Cobas 4800 HPV test (Roche Molecular Diagnostics). Results: The sensitivity for detection of HPV in the vaginal self-sampling test was 96.4% and in urine was 83.9% relative to detection by clinician-taken cervical sample. The vaginal self-sampling and the clinician-taken HPV tests had the same sensitivity of 92.8% (95% confidence interval=86.3-96.8%) and specificity for detection of high-grade squamous intraepithelial lesion (HSIL) and adenocarcinoma in situ (AIS). Detection in urine samples had a sensitivity of 76.3% (95% confidence interval=67.9-84.2%) for HSIL/AIS. Conclusion: The Cobas 4800 HPV test detects high-grade pre-cancerous cervical lesions in self-collected vaginal samples with the same high sensitivity as in clinician-taken cervical samples.</p>}}, author = {{Asciutto, Katrin Christine and Henningsson, Anna J and Borgfeldt, Henrik and Darlin, Lotten and Borgfeldt, Christer}}, issn = {{0250-7005}}, keywords = {{Cytology; HPV analysis; Self-collected vaginal smear; Vaginal smear}}, language = {{eng}}, month = {{08}}, number = {{8}}, pages = {{4183--4187}}, publisher = {{International Institute of Cancer Research}}, series = {{Anticancer research}}, title = {{Vaginal and urine self-sampling compared to cervical sampling for HPV-testing with the cobas 4800 HPV test}}, url = {{http://dx.doi.org/10.21873/anticanres.11807}}, doi = {{10.21873/anticanres.11807}}, volume = {{37}}, year = {{2017}}, }