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Non-covalent molecular imprinting with emphasis on its application in separation and drug development

Zhang, Huiqi LU ; Ye, Lei LU orcid and Mosbach, Klaus LU (2006) Bioaffinity 2005 19(4). p.248-259
Abstract
The molecular imprinting technique can be defined as the formation of specific nano-sized cavities by means of template-directed synthesis. The resulting molecularly imprinted polymers (MIPs), which often have an affinity and a selectivity approaching those of antibody-antigen systems, have thus been coined "artificial antibodies." MIPs are characterized by their high specificity, ease of preparation, and their thermal and chemical stability. They have been widely studied in connection with many potential applications, including their use for separation and isolation purposes, as antibody mimics (biomimetic assays and sensors), as enzyme mimics, in organic synthesis, and in drug delivery. The non-covalent imprinting approach, developed... (More)
The molecular imprinting technique can be defined as the formation of specific nano-sized cavities by means of template-directed synthesis. The resulting molecularly imprinted polymers (MIPs), which often have an affinity and a selectivity approaching those of antibody-antigen systems, have thus been coined "artificial antibodies." MIPs are characterized by their high specificity, ease of preparation, and their thermal and chemical stability. They have been widely studied in connection with many potential applications, including their use for separation and isolation purposes, as antibody mimics (biomimetic assays and sensors), as enzyme mimics, in organic synthesis, and in drug delivery. The non-covalent imprinting approach, developed mainly in Lund, has proven to be more versatile than the alternative covalent approach because of its preparation being less complicated and of the broad selection of functional monomers and possible target molecules that are available. The paper presents a review of studies of this versatile technique in the areas of separation and drug development, with emphasis being placed on work carried out in our laboratory. Copyright (c) 2006 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
drug, non-covalent approach, separation, molecular imprinting, development
host publication
Journal of Molecular Recognition
volume
19
issue
4
pages
248 - 259
publisher
John Wiley and Sons
conference name
Bioaffinity 2005
conference location
Upsala, Sweden
conference dates
2005-08-14 - 2005-08-18
external identifiers
  • wos:000239882300002
  • scopus:33747313879
  • pmid:16924655
ISSN
1099-1352
0952-3499
DOI
10.1002/jmr.793
language
English
LU publication?
yes
id
0a9e3bd0-70fa-4897-9670-c5eee4f6b645 (old id 397355)
date added to LUP
2016-04-01 11:39:53
date last changed
2021-09-15 02:49:48
@inproceedings{0a9e3bd0-70fa-4897-9670-c5eee4f6b645,
  abstract     = {The molecular imprinting technique can be defined as the formation of specific nano-sized cavities by means of template-directed synthesis. The resulting molecularly imprinted polymers (MIPs), which often have an affinity and a selectivity approaching those of antibody-antigen systems, have thus been coined "artificial antibodies." MIPs are characterized by their high specificity, ease of preparation, and their thermal and chemical stability. They have been widely studied in connection with many potential applications, including their use for separation and isolation purposes, as antibody mimics (biomimetic assays and sensors), as enzyme mimics, in organic synthesis, and in drug delivery. The non-covalent imprinting approach, developed mainly in Lund, has proven to be more versatile than the alternative covalent approach because of its preparation being less complicated and of the broad selection of functional monomers and possible target molecules that are available. The paper presents a review of studies of this versatile technique in the areas of separation and drug development, with emphasis being placed on work carried out in our laboratory. Copyright (c) 2006 John Wiley & Sons, Ltd.},
  author       = {Zhang, Huiqi and Ye, Lei and Mosbach, Klaus},
  booktitle    = {Journal of Molecular Recognition},
  issn         = {1099-1352},
  language     = {eng},
  number       = {4},
  pages        = {248--259},
  publisher    = {John Wiley and Sons},
  title        = {Non-covalent molecular imprinting with emphasis on its application in separation and drug development},
  url          = {http://dx.doi.org/10.1002/jmr.793},
  doi          = {10.1002/jmr.793},
  volume       = {19},
  year         = {2006},
}