Non-covalent molecular imprinting with emphasis on its application in separation and drug development
Zhang, Huiqi LU ; Ye, Lei LU
and Mosbach, Klaus
LU
(2006)
Bioaffinity 2005
19(4).
p.248-259
- Abstract
- The molecular imprinting technique can be defined as the formation of specific nano-sized cavities by means of template-directed synthesis. The resulting molecularly imprinted polymers (MIPs), which often have an affinity and a selectivity approaching those of antibody-antigen systems, have thus been coined "artificial antibodies." MIPs are characterized by their high specificity, ease of preparation, and their thermal and chemical stability. They have been widely studied in connection with many potential applications, including their use for separation and isolation purposes, as antibody mimics (biomimetic assays and sensors), as enzyme mimics, in organic synthesis, and in drug delivery. The non-covalent imprinting approach, developed... (More)
- The molecular imprinting technique can be defined as the formation of specific nano-sized cavities by means of template-directed synthesis. The resulting molecularly imprinted polymers (MIPs), which often have an affinity and a selectivity approaching those of antibody-antigen systems, have thus been coined "artificial antibodies." MIPs are characterized by their high specificity, ease of preparation, and their thermal and chemical stability. They have been widely studied in connection with many potential applications, including their use for separation and isolation purposes, as antibody mimics (biomimetic assays and sensors), as enzyme mimics, in organic synthesis, and in drug delivery. The non-covalent imprinting approach, developed mainly in Lund, has proven to be more versatile than the alternative covalent approach because of its preparation being less complicated and of the broad selection of functional monomers and possible target molecules that are available. The paper presents a review of studies of this versatile technique in the areas of separation and drug development, with emphasis being placed on work carried out in our laboratory. Copyright (c) 2006 John Wiley & Sons, Ltd. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/397355
- author
- Zhang, Huiqi
LU
; Ye, Lei
LU
and Mosbach, Klaus
LU
- organization
- publishing date
- 2006
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- drug, non-covalent approach, separation, molecular imprinting, development
- host publication
- Journal of Molecular Recognition
- volume
- 19
- issue
- 4
- pages
- 248 - 259
- publisher
- John Wiley & Sons Inc.
- conference name
- Bioaffinity 2005
- conference location
- Upsala, Sweden
- conference dates
- 2005-08-14 - 2005-08-18
- external identifiers
-
- wos:000239882300002
- scopus:33747313879
- pmid:16924655
- ISSN
- 0952-3499
- 1099-1352
- DOI
- 10.1002/jmr.793
- language
- English
- LU publication?
- yes
- id
- 0a9e3bd0-70fa-4897-9670-c5eee4f6b645 (old id 397355)
- date added to LUP
- 2016-04-01 11:39:53
- date last changed
- 2024-11-19 08:54:53
@inproceedings{0a9e3bd0-70fa-4897-9670-c5eee4f6b645,
abstract = {{The molecular imprinting technique can be defined as the formation of specific nano-sized cavities by means of template-directed synthesis. The resulting molecularly imprinted polymers (MIPs), which often have an affinity and a selectivity approaching those of antibody-antigen systems, have thus been coined "artificial antibodies." MIPs are characterized by their high specificity, ease of preparation, and their thermal and chemical stability. They have been widely studied in connection with many potential applications, including their use for separation and isolation purposes, as antibody mimics (biomimetic assays and sensors), as enzyme mimics, in organic synthesis, and in drug delivery. The non-covalent imprinting approach, developed mainly in Lund, has proven to be more versatile than the alternative covalent approach because of its preparation being less complicated and of the broad selection of functional monomers and possible target molecules that are available. The paper presents a review of studies of this versatile technique in the areas of separation and drug development, with emphasis being placed on work carried out in our laboratory. Copyright (c) 2006 John Wiley & Sons, Ltd.}},
author = {{Zhang, Huiqi and Ye, Lei and Mosbach, Klaus}},
booktitle = {{Journal of Molecular Recognition}},
issn = {{0952-3499}},
keywords = {{drug; non-covalent approach; separation; molecular imprinting; development}},
language = {{eng}},
number = {{4}},
pages = {{248--259}},
publisher = {{John Wiley & Sons Inc.}},
title = {{Non-covalent molecular imprinting with emphasis on its application in separation and drug development}},
url = {{http://dx.doi.org/10.1002/jmr.793}},
doi = {{10.1002/jmr.793}},
volume = {{19}},
year = {{2006}},
}