Synthesis of Substituted Oxazoles from N-Benzyl Propargyl Amines and Acid Chlorides
(2013) In European Journal of Organic Chemistry 2013(21). p.4578-4585- Abstract
- The reaction between N-benzylpropargylamines and acid chlorides at elevated temperatures provides efficient, direct access to a variety of di- and tri-substituted oxazoles. The versatility of this reaction is explored and 21 examples are demonstrated. The usefulness of the methodology is showcased through the short and efficient formal syntheses of medicinally relevant drugs aleglitazar and romazarit.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3975926
- author
- von Wachenfeldt, Henrik LU ; Paulsen, Filip ; Sundin, Anders LU and Strand, Daniel LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Synthetic methods, Cyclization, Heterocycles, Microwave chemistry
- in
- European Journal of Organic Chemistry
- volume
- 2013
- issue
- 21
- pages
- 4578 - 4585
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000321573300020
- scopus:84880042084
- ISSN
- 1434-193X
- DOI
- 10.1002/ejoc.201300285
- language
- English
- LU publication?
- yes
- id
- c1b130f6-e161-4afb-8053-ca3e6041aea5 (old id 3975926)
- date added to LUP
- 2016-04-01 11:09:01
- date last changed
- 2022-01-26 05:50:21
@article{c1b130f6-e161-4afb-8053-ca3e6041aea5, abstract = {{The reaction between N-benzylpropargylamines and acid chlorides at elevated temperatures provides efficient, direct access to a variety of di- and tri-substituted oxazoles. The versatility of this reaction is explored and 21 examples are demonstrated. The usefulness of the methodology is showcased through the short and efficient formal syntheses of medicinally relevant drugs aleglitazar and romazarit.}}, author = {{von Wachenfeldt, Henrik and Paulsen, Filip and Sundin, Anders and Strand, Daniel}}, issn = {{1434-193X}}, keywords = {{Synthetic methods; Cyclization; Heterocycles; Microwave chemistry}}, language = {{eng}}, number = {{21}}, pages = {{4578--4585}}, publisher = {{John Wiley & Sons Inc.}}, series = {{European Journal of Organic Chemistry}}, title = {{Synthesis of Substituted Oxazoles from N-Benzyl Propargyl Amines and Acid Chlorides}}, url = {{http://dx.doi.org/10.1002/ejoc.201300285}}, doi = {{10.1002/ejoc.201300285}}, volume = {{2013}}, year = {{2013}}, }