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Topical glucocorticosteroids in rhinitis: clinical aspects

Mygind, Niels and Andersson, Morgan LU (2006) In Acta Oto-Laryngologica 126(10). p.1022-1029
Abstract
The introduction of nasal glucocorticosteroids, 30 years ago, has been the most important therapeutic progress in rhinitis management since the introduction of the first generation of antihistamines. Our knowledge of the mode of action of glucocorticosteroids in the nose has improved as the airway mucous membrane of the nose is easily accessible for investigation. However, the exact mechanism behind the marked clinical effect remains unclear. Topical glucocorticosteroids are highly effective in diseases characterized by eosinophil-dominated inflammation ( allergic rhinitis, nasal polyposis), but not in diseases characterized by neutrophil-dominated inflammation ( common cold, infectious rhinosinusitis). Experience for 30 years and a long... (More)
The introduction of nasal glucocorticosteroids, 30 years ago, has been the most important therapeutic progress in rhinitis management since the introduction of the first generation of antihistamines. Our knowledge of the mode of action of glucocorticosteroids in the nose has improved as the airway mucous membrane of the nose is easily accessible for investigation. However, the exact mechanism behind the marked clinical effect remains unclear. Topical glucocorticosteroids are highly effective in diseases characterized by eosinophil-dominated inflammation ( allergic rhinitis, nasal polyposis), but not in diseases characterized by neutrophil-dominated inflammation ( common cold, infectious rhinosinusitis). Experience for 30 years and a long series of controlled studies have shown that the treatment is highly effective and that the side effects are few and benign. Intranasal glucocorticosteroids can therefore be considered as first-line treatment for allergic and non-allergic, non-infectious rhinitis and nasal polyps. (Less)
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Oto-Laryngologica
volume
126
issue
10
pages
1022 - 1029
publisher
Taylor & Francis
external identifiers
  • wos:000239950300002
  • scopus:33747686156
ISSN
1651-2251
DOI
10.1080/00016480600672550
language
English
LU publication?
yes
id
54924fd7-7253-41ad-80e9-cdc2f0117e67 (old id 397602)
date added to LUP
2016-04-01 15:34:33
date last changed
2020-08-26 03:01:00
@article{54924fd7-7253-41ad-80e9-cdc2f0117e67,
  abstract     = {The introduction of nasal glucocorticosteroids, 30 years ago, has been the most important therapeutic progress in rhinitis management since the introduction of the first generation of antihistamines. Our knowledge of the mode of action of glucocorticosteroids in the nose has improved as the airway mucous membrane of the nose is easily accessible for investigation. However, the exact mechanism behind the marked clinical effect remains unclear. Topical glucocorticosteroids are highly effective in diseases characterized by eosinophil-dominated inflammation ( allergic rhinitis, nasal polyposis), but not in diseases characterized by neutrophil-dominated inflammation ( common cold, infectious rhinosinusitis). Experience for 30 years and a long series of controlled studies have shown that the treatment is highly effective and that the side effects are few and benign. Intranasal glucocorticosteroids can therefore be considered as first-line treatment for allergic and non-allergic, non-infectious rhinitis and nasal polyps.},
  author       = {Mygind, Niels and Andersson, Morgan},
  issn         = {1651-2251},
  language     = {eng},
  number       = {10},
  pages        = {1022--1029},
  publisher    = {Taylor & Francis},
  series       = {Acta Oto-Laryngologica},
  title        = {Topical glucocorticosteroids in rhinitis: clinical aspects},
  url          = {http://dx.doi.org/10.1080/00016480600672550},
  doi          = {10.1080/00016480600672550},
  volume       = {126},
  year         = {2006},
}