New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A
(2006) In Organic and Biomolecular Chemistry 4(16). p.3067-3076- Abstract
- Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/399031
- author
- Fagerström, Alexandra LU ; Nilsson, Mikael ; Berg, Ulf LU and Isaksson, Roland LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Organic and Biomolecular Chemistry
- volume
- 4
- issue
- 16
- pages
- 3067 - 3076
- publisher
- Royal Society of Chemistry
- external identifiers
-
- pmid:16886073
- wos:000239508100008
- scopus:33746905114
- ISSN
- 1477-0539
- DOI
- 10.1039/b605603b
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- e072d00c-1e1e-4950-acbd-655c7e0304ad (old id 399031)
- date added to LUP
- 2016-04-01 12:27:54
- date last changed
- 2022-01-27 05:26:35
@article{e072d00c-1e1e-4950-acbd-655c7e0304ad, abstract = {{Novel propranolol analogues have been designed and synthesised and their enantioselective binding to the cellulose degrading enzyme, Cel7A, has been evaluated. Affinity and enantioselectivity have been determined by capillary electrophoresis experiments. Ligands with significantly improved affinity and selectivity have been obtained and an analysis of the results has led to insights concerning the relation between the changes in ligand structure and selectivity as well as affinity to the protein.}}, author = {{Fagerström, Alexandra and Nilsson, Mikael and Berg, Ulf and Isaksson, Roland}}, issn = {{1477-0539}}, language = {{eng}}, number = {{16}}, pages = {{3067--3076}}, publisher = {{Royal Society of Chemistry}}, series = {{Organic and Biomolecular Chemistry}}, title = {{New propranolol analogues: binding and chiral discrimination by cellobiohydrolase Cel7A}}, url = {{http://dx.doi.org/10.1039/b605603b}}, doi = {{10.1039/b605603b}}, volume = {{4}}, year = {{2006}}, }