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Mouse models of induced otitis media

Ryan, Allen F. ; Ebmeyer, Joerg ; Furukawa, Masayuki ; Pak, Kwang ; Melhus, Åsa LU ; Wasserman, Stephen I. and Chung, Won-Ho (2006) In Brain Research 1091. p.3-8
Abstract
The mouse has seen limited use as a model for experimental otitis media, due primarily to the small size of its middle ear. However, the genetic resources of this species offer substantial potential benefits. These include detailed genomic information, a wealth of genetic models, and gene arrays that represent virtually all mouse genes. This has led to the development of methods for inducing otitis in mice. These include surgical approaches to the middle ear, documentation of the murine middle ear response to various pathogens and inflammatory factors, as well as characterization of induced otitis media in several mouse strains. The results indicate that induced otitis media in the normal mouse is in most respects comparable to that... (More)
The mouse has seen limited use as a model for experimental otitis media, due primarily to the small size of its middle ear. However, the genetic resources of this species offer substantial potential benefits. These include detailed genomic information, a wealth of genetic models, and gene arrays that represent virtually all mouse genes. This has led to the development of methods for inducing otitis in mice. These include surgical approaches to the middle ear, documentation of the murine middle ear response to various pathogens and inflammatory factors, as well as characterization of induced otitis media in several mouse strains. The results indicate that induced otitis media in the normal mouse is in most respects comparable to that observed in other animal models and in humans. They further suggest that the considerable genetic resources of this species can be harnessed to increase our understanding of this disease. (c) 2006 Published by Elsevier B.V. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
tympanic cavity, mouse models, middle ear, otitis media, microbiology, genetics
in
Brain Research
volume
1091
pages
3 - 8
publisher
Elsevier
external identifiers
  • pmid:16764829
  • wos:000239351500002
  • scopus:33745624550
  • pmid:16764829
ISSN
1872-6240
DOI
10.1016/j.brainres.2006.02.004
language
English
LU publication?
yes
id
a784961e-767c-425d-b037-500648de651e (old id 399620)
date added to LUP
2016-04-01 12:31:10
date last changed
2021-09-22 04:42:16
@article{a784961e-767c-425d-b037-500648de651e,
  abstract     = {The mouse has seen limited use as a model for experimental otitis media, due primarily to the small size of its middle ear. However, the genetic resources of this species offer substantial potential benefits. These include detailed genomic information, a wealth of genetic models, and gene arrays that represent virtually all mouse genes. This has led to the development of methods for inducing otitis in mice. These include surgical approaches to the middle ear, documentation of the murine middle ear response to various pathogens and inflammatory factors, as well as characterization of induced otitis media in several mouse strains. The results indicate that induced otitis media in the normal mouse is in most respects comparable to that observed in other animal models and in humans. They further suggest that the considerable genetic resources of this species can be harnessed to increase our understanding of this disease. (c) 2006 Published by Elsevier B.V.},
  author       = {Ryan, Allen F. and Ebmeyer, Joerg and Furukawa, Masayuki and Pak, Kwang and Melhus, Åsa and Wasserman, Stephen I. and Chung, Won-Ho},
  issn         = {1872-6240},
  language     = {eng},
  pages        = {3--8},
  publisher    = {Elsevier},
  series       = {Brain Research},
  title        = {Mouse models of induced otitis media},
  url          = {http://dx.doi.org/10.1016/j.brainres.2006.02.004},
  doi          = {10.1016/j.brainres.2006.02.004},
  volume       = {1091},
  year         = {2006},
}