Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case-control study in China
Zhang, Naiqi LU
; Ho, Suzanne C
; Mo, Xiong-Fei
; Lin, Fang-Yu
; Huang, Wuqing
LU
; Luo, Hong
; Huang, Jing
and Zhang, Cai-xia
(2018)
In British Journal of Nutrition
119(8).
p.957-964
- Abstract
- Although previous studies have investigated the association of cruciferous vegetable consumption with breast cancer risk, few studies focused on the association between bioactive components in cruciferous vegetables, glucosinolates (GSL) and isothiocyanates (ITC), and breast cancer risk. This study aimed to examine the association between consumption of cruciferous vegetables and breast cancer risk according to GSL and ITC contents in a Chinese population. A total of 1485 cases and 1506 controls were recruited into this case-control study from June 2007 to March 2017. Consumption of cruciferous vegetables was assessed using a validated FFQ. Dietary GSL and ITC were computed by using two food composition databases linking GSL and ITC... (More)
- Although previous studies have investigated the association of cruciferous vegetable consumption with breast cancer risk, few studies focused on the association between bioactive components in cruciferous vegetables, glucosinolates (GSL) and isothiocyanates (ITC), and breast cancer risk. This study aimed to examine the association between consumption of cruciferous vegetables and breast cancer risk according to GSL and ITC contents in a Chinese population. A total of 1485 cases and 1506 controls were recruited into this case-control study from June 2007 to March 2017. Consumption of cruciferous vegetables was assessed using a validated FFQ. Dietary GSL and ITC were computed by using two food composition databases linking GSL and ITC contents in cruciferous vegetables with responses to the FFQ. The OR and 95 % CI were assessed by unconditional logistic regression after adjusting for the potential confounders. Significant inverse associations were found between consumption of cruciferous vegetables, GSL and ITC and breast cancer risk. The adjusted OR comparing the highest with the lowest quartile were 0·51 (95 % CI 0·41, 0·63) for cruciferous vegetables, 0·54 (95 % CI 0·44, 0·67) for GSL and 0·62 (95 % CI 0·50, 0·76) for ITC, respectively. These inverse associations were also observed in both premenopausal and postmenopausal women. Subgroup analysis by hormone receptor status found inverse associations between cruciferous vegetables, GSL and ITC and both hormone-receptor-positive or hormone-receptor-negative breast cancer. This study indicated that consumption of cruciferous vegetables, GSL and ITC was inversely associated with breast cancer risk among Chinese women. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/39b2c88b-a15d-4929-8f0e-d30e8fc5836f
- author
- Zhang, Naiqi
LU
; Ho, Suzanne C
; Mo, Xiong-Fei
; Lin, Fang-Yu
; Huang, Wuqing
LU
; Luo, Hong
; Huang, Jing
and Zhang, Cai-xia
- publishing date
- 2018-04
- type
- Contribution to journal
- publication status
- published
- in
- British Journal of Nutrition
- volume
- 119
- issue
- 8
- pages
- 957 - 964
- publisher
- Cambridge University Press
- external identifiers
-
- scopus:85045556930
- ISSN
- 1475-2662
- DOI
- 10.1017/S0007114518000600
- language
- English
- LU publication?
- no
- id
- 39b2c88b-a15d-4929-8f0e-d30e8fc5836f
- date added to LUP
- 2025-01-21 13:58:04
- date last changed
- 2025-04-30 14:22:57
@article{39b2c88b-a15d-4929-8f0e-d30e8fc5836f,
abstract = {{Although previous studies have investigated the association of cruciferous vegetable consumption with breast cancer risk, few studies focused on the association between bioactive components in cruciferous vegetables, glucosinolates (GSL) and isothiocyanates (ITC), and breast cancer risk. This study aimed to examine the association between consumption of cruciferous vegetables and breast cancer risk according to GSL and ITC contents in a Chinese population. A total of 1485 cases and 1506 controls were recruited into this case-control study from June 2007 to March 2017. Consumption of cruciferous vegetables was assessed using a validated FFQ. Dietary GSL and ITC were computed by using two food composition databases linking GSL and ITC contents in cruciferous vegetables with responses to the FFQ. The OR and 95 % CI were assessed by unconditional logistic regression after adjusting for the potential confounders. Significant inverse associations were found between consumption of cruciferous vegetables, GSL and ITC and breast cancer risk. The adjusted OR comparing the highest with the lowest quartile were 0·51 (95 % CI 0·41, 0·63) for cruciferous vegetables, 0·54 (95 % CI 0·44, 0·67) for GSL and 0·62 (95 % CI 0·50, 0·76) for ITC, respectively. These inverse associations were also observed in both premenopausal and postmenopausal women. Subgroup analysis by hormone receptor status found inverse associations between cruciferous vegetables, GSL and ITC and both hormone-receptor-positive or hormone-receptor-negative breast cancer. This study indicated that consumption of cruciferous vegetables, GSL and ITC was inversely associated with breast cancer risk among Chinese women.}},
author = {{Zhang, Naiqi and Ho, Suzanne C and Mo, Xiong-Fei and Lin, Fang-Yu and Huang, Wuqing and Luo, Hong and Huang, Jing and Zhang, Cai-xia}},
issn = {{1475-2662}},
language = {{eng}},
number = {{8}},
pages = {{957--964}},
publisher = {{Cambridge University Press}},
series = {{British Journal of Nutrition}},
title = {{Glucosinolate and isothiocyanate intakes are inversely associated with breast cancer risk: a case-control study in China}},
url = {{http://dx.doi.org/10.1017/S0007114518000600}},
doi = {{10.1017/S0007114518000600}},
volume = {{119}},
year = {{2018}},
}