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Breathlessness and incidence of COPD, cardiac events and all-cause mortality : A 44-year follow-up from middle age throughout life

Sandberg, Jacob LU ; Engström, Gunnar LU and Ekström, Magnus LU (2019) In PLoS ONE 14(3).
Abstract

Background Breathlessness is prevalent in the general population and may be associated with adverse health outcomes. This study aimed to evaluate the association of breathlessness with Chronic Obstructive Pulmonary Disease (COPD) events, cardiac events and all-cause mortality from middle-age throughout life. Methods Breathlessness was measured in 699, 55-year old men residing in Malmö, Sweden using modified Medical Research Council (mMRC). COPD events (hospitalisation, death or diagnosis) cardiac events and all-cause mortality was assessed using The Swedish Causes of Death Register and Hospital Discharge Register. Data was analyzed using Cox- and competing risks (Fine-Gray) regression analysis. Results 695 (99%) of 699 participants died... (More)

Background Breathlessness is prevalent in the general population and may be associated with adverse health outcomes. This study aimed to evaluate the association of breathlessness with Chronic Obstructive Pulmonary Disease (COPD) events, cardiac events and all-cause mortality from middle-age throughout life. Methods Breathlessness was measured in 699, 55-year old men residing in Malmö, Sweden using modified Medical Research Council (mMRC). COPD events (hospitalisation, death or diagnosis) cardiac events and all-cause mortality was assessed using The Swedish Causes of Death Register and Hospital Discharge Register. Data was analyzed using Cox- and competing risks (Fine-Gray) regression analysis. Results 695 (99%) of 699 participants died and four emigrated during follow up. Eighty-seven (12%) had mMRC = 1 and 19 (3%) had mMRC2. Breathlessness was associated with COPD events; adjusted Sub-Hazard Ratio 2.1 (95% CI, 1.2–3.6) for mMRC = 1 and 7.5 (2.6–21.7) for mMRC 2 but not associated with cardiac events when adjusting for competing events and confounding. Breathlessness was associated increased all- cause mortality (Hazard Ratios of 1.4 (1.1–1.7) (mMRC = 1) and 3.4 (2.1–5.6) (mMRC 2)). Conclusion Breathlessness is associated with increased risk of COPD events and increase in all-cause mortality from age 55 until death.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
PLoS ONE
volume
14
issue
3
article number
e0214083
publisher
Public Library of Science
external identifiers
  • pmid:30883602
  • scopus:85063258394
ISSN
1932-6203
DOI
10.1371/journal.pone.0214083
language
English
LU publication?
yes
id
39d9dd23-4d35-4e70-8d38-d0597efdc6df
date added to LUP
2019-04-02 09:41:56
date last changed
2020-07-08 04:46:39
@article{39d9dd23-4d35-4e70-8d38-d0597efdc6df,
  abstract     = {<p>Background Breathlessness is prevalent in the general population and may be associated with adverse health outcomes. This study aimed to evaluate the association of breathlessness with Chronic Obstructive Pulmonary Disease (COPD) events, cardiac events and all-cause mortality from middle-age throughout life. Methods Breathlessness was measured in 699, 55-year old men residing in Malmö, Sweden using modified Medical Research Council (mMRC). COPD events (hospitalisation, death or diagnosis) cardiac events and all-cause mortality was assessed using The Swedish Causes of Death Register and Hospital Discharge Register. Data was analyzed using Cox- and competing risks (Fine-Gray) regression analysis. Results 695 (99%) of 699 participants died and four emigrated during follow up. Eighty-seven (12%) had mMRC = 1 and 19 (3%) had mMRC2. Breathlessness was associated with COPD events; adjusted Sub-Hazard Ratio 2.1 (95% CI, 1.2–3.6) for mMRC = 1 and 7.5 (2.6–21.7) for mMRC 2 but not associated with cardiac events when adjusting for competing events and confounding. Breathlessness was associated increased all- cause mortality (Hazard Ratios of 1.4 (1.1–1.7) (mMRC = 1) and 3.4 (2.1–5.6) (mMRC 2)). Conclusion Breathlessness is associated with increased risk of COPD events and increase in all-cause mortality from age 55 until death.</p>},
  author       = {Sandberg, Jacob and Engström, Gunnar and Ekström, Magnus},
  issn         = {1932-6203},
  language     = {eng},
  month        = {03},
  number       = {3},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {Breathlessness and incidence of COPD, cardiac events and all-cause mortality : A 44-year follow-up from middle age throughout life},
  url          = {http://dx.doi.org/10.1371/journal.pone.0214083},
  doi          = {10.1371/journal.pone.0214083},
  volume       = {14},
  year         = {2019},
}