In search of environmental risk factors for obsessive-compulsive disorder : study protocol for the OCDTWIN project
(2023) In BMC Psychiatry 23(1).- Abstract
Background: The causes of obsessive-compulsive disorder (OCD) remain unknown. Gene-searching efforts are well underway, but the identification of environmental risk factors is at least as important and should be a priority because some of them may be amenable to prevention or early intervention strategies. Genetically informative studies, particularly those employing the discordant monozygotic (MZ) twin design, are ideally suited to study environmental risk factors. This protocol paper describes the study rationale, aims, and methods of OCDTWIN, an open cohort of MZ twin pairs who are discordant for the diagnosis of OCD. Methods: OCDTWIN has two broad aims. In Aim 1, we are recruiting MZ twin pairs from across Sweden, conducting... (More)
Background: The causes of obsessive-compulsive disorder (OCD) remain unknown. Gene-searching efforts are well underway, but the identification of environmental risk factors is at least as important and should be a priority because some of them may be amenable to prevention or early intervention strategies. Genetically informative studies, particularly those employing the discordant monozygotic (MZ) twin design, are ideally suited to study environmental risk factors. This protocol paper describes the study rationale, aims, and methods of OCDTWIN, an open cohort of MZ twin pairs who are discordant for the diagnosis of OCD. Methods: OCDTWIN has two broad aims. In Aim 1, we are recruiting MZ twin pairs from across Sweden, conducting thorough clinical assessments, and building a biobank of biological specimens, including blood, saliva, urine, stool, hair, nails, and multimodal brain imaging. A wealth of early life exposures (e.g., perinatal variables, health-related information, psychosocial stressors) are available through linkage with the nationwide registers and the Swedish Twin Registry. Blood spots stored in the Swedish phenylketonuria (PKU) biobank will be available to extract DNA, proteins, and metabolites, providing an invaluable source of biomaterial taken at birth. In Aim 2, we will perform within-pair comparisons of discordant MZ twins, which will allow us to isolate unique environmental risk factors that are in the causal pathway to OCD, while strictly controlling for genetic and early shared environmental influences. To date (May 2023), 43 pairs of twins (21 discordant for OCD) have been recruited. Discussion: OCDTWIN hopes to generate unique insights into environmental risk factors that are in the causal pathway to OCD, some of which have the potential of being actionable targets.
(Less)
- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Discordant twins, Early intervention, Environmental risk factors, Monozygotic twins, Obsessive-compulsive disorder, Prevention
- in
- BMC Psychiatry
- volume
- 23
- issue
- 1
- article number
- 442
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:37328750
- scopus:85161978078
- ISSN
- 1471-244X
- DOI
- 10.1186/s12888-023-04897-4
- language
- English
- LU publication?
- yes
- id
- 3a114c76-cc88-4028-9af3-1180d3077f3c
- date added to LUP
- 2023-08-28 13:39:10
- date last changed
- 2024-04-20 03:07:07
@article{3a114c76-cc88-4028-9af3-1180d3077f3c,
abstract = {{<p>Background: The causes of obsessive-compulsive disorder (OCD) remain unknown. Gene-searching efforts are well underway, but the identification of environmental risk factors is at least as important and should be a priority because some of them may be amenable to prevention or early intervention strategies. Genetically informative studies, particularly those employing the discordant monozygotic (MZ) twin design, are ideally suited to study environmental risk factors. This protocol paper describes the study rationale, aims, and methods of OCDTWIN, an open cohort of MZ twin pairs who are discordant for the diagnosis of OCD. Methods: OCDTWIN has two broad aims. In Aim 1, we are recruiting MZ twin pairs from across Sweden, conducting thorough clinical assessments, and building a biobank of biological specimens, including blood, saliva, urine, stool, hair, nails, and multimodal brain imaging. A wealth of early life exposures (e.g., perinatal variables, health-related information, psychosocial stressors) are available through linkage with the nationwide registers and the Swedish Twin Registry. Blood spots stored in the Swedish phenylketonuria (PKU) biobank will be available to extract DNA, proteins, and metabolites, providing an invaluable source of biomaterial taken at birth. In Aim 2, we will perform within-pair comparisons of discordant MZ twins, which will allow us to isolate unique environmental risk factors that are in the causal pathway to OCD, while strictly controlling for genetic and early shared environmental influences. To date (May 2023), 43 pairs of twins (21 discordant for OCD) have been recruited. Discussion: OCDTWIN hopes to generate unique insights into environmental risk factors that are in the causal pathway to OCD, some of which have the potential of being actionable targets.</p>}},
author = {{Mataix-Cols, David and Fernández de la Cruz, Lorena and De Schipper, Elles and Kuja-Halkola, Ralf and Bulik, Cynthia M. and Crowley, James J. and Neufeld, Janina and Rück, Christian and Tammimies, Kristiina and Lichtenstein, Paul and Bölte, Sven and Beucke, Jan C.}},
issn = {{1471-244X}},
keywords = {{Discordant twins; Early intervention; Environmental risk factors; Monozygotic twins; Obsessive-compulsive disorder; Prevention}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Psychiatry}},
title = {{In search of environmental risk factors for obsessive-compulsive disorder : study protocol for the OCDTWIN project}},
url = {{http://dx.doi.org/10.1186/s12888-023-04897-4}},
doi = {{10.1186/s12888-023-04897-4}},
volume = {{23}},
year = {{2023}},
}