Antimicrobial, antiparasitic, anti-inflammatory, and cytotoxic activities of Lopezia racemosa
(2013) In The Scientific World Journal 2013.- Abstract
The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts and fractions were tested against a panel of nine bacterial and four fungal species. The antiparasitic activity was tested against Leishmania donovani, whereas the anti-inflammatory activity of the compounds was determined by measuring the secretion of interleukin-6 from human-derived macrophages. The same macrophage cell line was used to... (More)
The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts and fractions were tested against a panel of nine bacterial and four fungal species. The antiparasitic activity was tested against Leishmania donovani, whereas the anti-inflammatory activity of the compounds was determined by measuring the secretion of interleukin-6 from human-derived macrophages. The same macrophage cell line was used to investigate the cytotoxicity of the compounds. Various extracts and fractions showed antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. The hexanic fraction HF 11-14b was the most interesting fraction with antimicrobial, and anti-inflammatory activities. The benefit of L. racemosa as a traditional medicinal plant was confirmed as shown by its antibacterial, antifungal and anti-inflammatory activities. To the best of our knowledge, this is the first study reporting the biological activities of L. racemosa, including antiparasitic and anti-inflammatory activities.
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- author
- Cruz Paredes, Carla LU ; Bolívar Balbás, Paulina ; Gómez-Velasco, Anaximandro ; Juárez, Zaida Nelly ; Sánchez Arreola, Eugenio ; Hernández, Luis Ricardo and Bach, Horacio
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Anti-Infective Agents/pharmacology, Anti-Inflammatory Agents/pharmacology, Antiparasitic Agents/pharmacology, Bacterial Physiological Phenomena/drug effects, Cell Survival/drug effects, Cells, Cultured, Cytotoxins/pharmacology, Fungi/drug effects, Humans, Interleukin-6/immunology, Leishmania donovani/drug effects, Macrophages/cytology, Onagraceae/chemistry, Plant Extracts/pharmacology, Plants, Medicinal/chemistry, Survival
- in
- The Scientific World Journal
- volume
- 2013
- article number
- 237438
- pages
- 6 pages
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:23843731
- scopus:84880152784
- ISSN
- 1537-744X
- DOI
- 10.1155/2013/237438
- language
- English
- LU publication?
- no
- id
- 3a1433c1-7fff-476d-b9da-c3658ec9b681
- date added to LUP
- 2022-08-26 11:38:31
- date last changed
- 2024-05-14 12:37:51
@article{3a1433c1-7fff-476d-b9da-c3658ec9b681, abstract = {{<p>The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts and fractions were tested against a panel of nine bacterial and four fungal species. The antiparasitic activity was tested against Leishmania donovani, whereas the anti-inflammatory activity of the compounds was determined by measuring the secretion of interleukin-6 from human-derived macrophages. The same macrophage cell line was used to investigate the cytotoxicity of the compounds. Various extracts and fractions showed antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. The hexanic fraction HF 11-14b was the most interesting fraction with antimicrobial, and anti-inflammatory activities. The benefit of L. racemosa as a traditional medicinal plant was confirmed as shown by its antibacterial, antifungal and anti-inflammatory activities. To the best of our knowledge, this is the first study reporting the biological activities of L. racemosa, including antiparasitic and anti-inflammatory activities.</p>}}, author = {{Cruz Paredes, Carla and Bolívar Balbás, Paulina and Gómez-Velasco, Anaximandro and Juárez, Zaida Nelly and Sánchez Arreola, Eugenio and Hernández, Luis Ricardo and Bach, Horacio}}, issn = {{1537-744X}}, keywords = {{Anti-Infective Agents/pharmacology; Anti-Inflammatory Agents/pharmacology; Antiparasitic Agents/pharmacology; Bacterial Physiological Phenomena/drug effects; Cell Survival/drug effects; Cells, Cultured; Cytotoxins/pharmacology; Fungi/drug effects; Humans; Interleukin-6/immunology; Leishmania donovani/drug effects; Macrophages/cytology; Onagraceae/chemistry; Plant Extracts/pharmacology; Plants, Medicinal/chemistry; Survival}}, language = {{eng}}, publisher = {{Hindawi Limited}}, series = {{The Scientific World Journal}}, title = {{Antimicrobial, antiparasitic, anti-inflammatory, and cytotoxic activities of Lopezia racemosa}}, url = {{http://dx.doi.org/10.1155/2013/237438}}, doi = {{10.1155/2013/237438}}, volume = {{2013}}, year = {{2013}}, }