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Antimicrobial, antiparasitic, anti-inflammatory, and cytotoxic activities of Lopezia racemosa

Cruz Paredes, Carla LU orcid ; Bolívar Balbás, Paulina ; Gómez-Velasco, Anaximandro ; Juárez, Zaida Nelly ; Sánchez Arreola, Eugenio ; Hernández, Luis Ricardo and Bach, Horacio (2013) In The Scientific World Journal 2013.
Abstract

The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts and fractions were tested against a panel of nine bacterial and four fungal species. The antiparasitic activity was tested against Leishmania donovani, whereas the anti-inflammatory activity of the compounds was determined by measuring the secretion of interleukin-6 from human-derived macrophages. The same macrophage cell line was used to... (More)

The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts and fractions were tested against a panel of nine bacterial and four fungal species. The antiparasitic activity was tested against Leishmania donovani, whereas the anti-inflammatory activity of the compounds was determined by measuring the secretion of interleukin-6 from human-derived macrophages. The same macrophage cell line was used to investigate the cytotoxicity of the compounds. Various extracts and fractions showed antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. The hexanic fraction HF 11-14b was the most interesting fraction with antimicrobial, and anti-inflammatory activities. The benefit of L. racemosa as a traditional medicinal plant was confirmed as shown by its antibacterial, antifungal and anti-inflammatory activities. To the best of our knowledge, this is the first study reporting the biological activities of L. racemosa, including antiparasitic and anti-inflammatory activities.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Anti-Infective Agents/pharmacology, Anti-Inflammatory Agents/pharmacology, Antiparasitic Agents/pharmacology, Bacterial Physiological Phenomena/drug effects, Cell Survival/drug effects, Cells, Cultured, Cytotoxins/pharmacology, Fungi/drug effects, Humans, Interleukin-6/immunology, Leishmania donovani/drug effects, Macrophages/cytology, Onagraceae/chemistry, Plant Extracts/pharmacology, Plants, Medicinal/chemistry, Survival
in
The Scientific World Journal
volume
2013
article number
237438
pages
6 pages
publisher
Hindawi Limited
external identifiers
  • pmid:23843731
  • scopus:84880152784
ISSN
1537-744X
DOI
10.1155/2013/237438
language
English
LU publication?
no
id
3a1433c1-7fff-476d-b9da-c3658ec9b681
date added to LUP
2022-08-26 11:38:31
date last changed
2024-05-14 12:37:51
@article{3a1433c1-7fff-476d-b9da-c3658ec9b681,
  abstract     = {{<p>The present study investigates the potential benefits of the Mexican medicinal plant Lopezia racemosa (Onagraceae). Extracts and fractions from aerial parts of this plant were assessed to determine their antibacterial, antifungal, antiparasitic, anti-inflammatory and cytotoxic activities in vitro. Aerial parts of the plant were extracted with various solvents and fractionated accordingly. Extracts and fractions were tested against a panel of nine bacterial and four fungal species. The antiparasitic activity was tested against Leishmania donovani, whereas the anti-inflammatory activity of the compounds was determined by measuring the secretion of interleukin-6 from human-derived macrophages. The same macrophage cell line was used to investigate the cytotoxicity of the compounds. Various extracts and fractions showed antibacterial, antifungal, antiparasitic, and anti-inflammatory activities. The hexanic fraction HF 11-14b was the most interesting fraction with antimicrobial, and anti-inflammatory activities. The benefit of L. racemosa as a traditional medicinal plant was confirmed as shown by its antibacterial, antifungal and anti-inflammatory activities. To the best of our knowledge, this is the first study reporting the biological activities of L. racemosa, including antiparasitic and anti-inflammatory activities.</p>}},
  author       = {{Cruz Paredes, Carla and Bolívar Balbás, Paulina and Gómez-Velasco, Anaximandro and Juárez, Zaida Nelly and Sánchez Arreola, Eugenio and Hernández, Luis Ricardo and Bach, Horacio}},
  issn         = {{1537-744X}},
  keywords     = {{Anti-Infective Agents/pharmacology; Anti-Inflammatory Agents/pharmacology; Antiparasitic Agents/pharmacology; Bacterial Physiological Phenomena/drug effects; Cell Survival/drug effects; Cells, Cultured; Cytotoxins/pharmacology; Fungi/drug effects; Humans; Interleukin-6/immunology; Leishmania donovani/drug effects; Macrophages/cytology; Onagraceae/chemistry; Plant Extracts/pharmacology; Plants, Medicinal/chemistry; Survival}},
  language     = {{eng}},
  publisher    = {{Hindawi Limited}},
  series       = {{The Scientific World Journal}},
  title        = {{Antimicrobial, antiparasitic, anti-inflammatory, and cytotoxic activities of Lopezia racemosa}},
  url          = {{http://dx.doi.org/10.1155/2013/237438}},
  doi          = {{10.1155/2013/237438}},
  volume       = {{2013}},
  year         = {{2013}},
}