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Gastroenteritis and the novel picornaviruses aichi virus, cosavirus, saffold virus, and salivirus in young children

Nielsen, Alex Christian Yde; Gyhrs, Mette Louise; Nielsen, Lars Peter; Pedersen, Court and Böttiger, Blenda LU (2013) In Journal of Clinical Virology 57(3). p.239-242
Abstract
Background: During the last few years many new human picornaviruses have been discovered due to advances in metagenomics and other molecular biological approaches. The clinical significance and the occurrence are only sparsely described. Objectives: To determine the epidemiology and clinical significance of infections with the novel human picornaviruses, aichi virus, cosavirus, salivirus, and saffold virus in infants in Denmark. Study design: We tested 1393 stool samples from a birth cohort of 454 children for these viruses. Samples were collected at ages 6, 10 and 15 months, and at episodes of gastroenteritis. Samples were tested by real-time reverse-transcriptase polymerase chain reaction assays. Each study participant had a diary, where... (More)
Background: During the last few years many new human picornaviruses have been discovered due to advances in metagenomics and other molecular biological approaches. The clinical significance and the occurrence are only sparsely described. Objectives: To determine the epidemiology and clinical significance of infections with the novel human picornaviruses, aichi virus, cosavirus, salivirus, and saffold virus in infants in Denmark. Study design: We tested 1393 stool samples from a birth cohort of 454 children for these viruses. Samples were collected at ages 6, 10 and 15 months, and at episodes of gastroenteritis. Samples were tested by real-time reverse-transcriptase polymerase chain reaction assays. Each study participant had a diary, where the parents reported episodes of disease, including gastroenteritis. Results: Aichi virus, salivirus and saffold virus were detected in 6, 9 and 38 of the children, respectively, but cosavirus was not detected in any of the children. There was a clear seasonal variation with most infections occurring in autumn and winter. A statistically significant association between the findings of salivirus and gastrointestinal disease was demonstrated. There was no association between gastrointestinal disease and the presence of aichi virus or saffold virus. Conclusions: The newly discovered human picornaviruses aichi virus, saffold virus, and salivirus are circulating in Danish children, with the most common being saffold virus. Saffold virus was seen almost exclusively in the autumn and winter period. Salivirus was the only virus, which was significantly associated with gastroenteritis, although the number of positive samples was rather low. (C) 2013 Elsevier B. V. All rights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Novel human picornaviruses, Aichi virus, Cosavirus, Saffold virus, Salivirus
in
Journal of Clinical Virology
volume
57
issue
3
pages
239 - 242
publisher
Elsevier
external identifiers
  • wos:000320593300010
  • scopus:84891387843
ISSN
1386-6532
DOI
10.1016/j.jcv.2013.03.015
language
English
LU publication?
yes
id
3a1605f6-6064-4c35-baff-a3973ba70761 (old id 3980108)
date added to LUP
2013-09-02 12:26:36
date last changed
2018-05-13 03:01:51
@article{3a1605f6-6064-4c35-baff-a3973ba70761,
  abstract     = {Background: During the last few years many new human picornaviruses have been discovered due to advances in metagenomics and other molecular biological approaches. The clinical significance and the occurrence are only sparsely described. Objectives: To determine the epidemiology and clinical significance of infections with the novel human picornaviruses, aichi virus, cosavirus, salivirus, and saffold virus in infants in Denmark. Study design: We tested 1393 stool samples from a birth cohort of 454 children for these viruses. Samples were collected at ages 6, 10 and 15 months, and at episodes of gastroenteritis. Samples were tested by real-time reverse-transcriptase polymerase chain reaction assays. Each study participant had a diary, where the parents reported episodes of disease, including gastroenteritis. Results: Aichi virus, salivirus and saffold virus were detected in 6, 9 and 38 of the children, respectively, but cosavirus was not detected in any of the children. There was a clear seasonal variation with most infections occurring in autumn and winter. A statistically significant association between the findings of salivirus and gastrointestinal disease was demonstrated. There was no association between gastrointestinal disease and the presence of aichi virus or saffold virus. Conclusions: The newly discovered human picornaviruses aichi virus, saffold virus, and salivirus are circulating in Danish children, with the most common being saffold virus. Saffold virus was seen almost exclusively in the autumn and winter period. Salivirus was the only virus, which was significantly associated with gastroenteritis, although the number of positive samples was rather low. (C) 2013 Elsevier B. V. All rights reserved.},
  author       = {Nielsen, Alex Christian Yde and Gyhrs, Mette Louise and Nielsen, Lars Peter and Pedersen, Court and Böttiger, Blenda},
  issn         = {1386-6532},
  keyword      = {Novel human picornaviruses,Aichi virus,Cosavirus,Saffold virus,Salivirus},
  language     = {eng},
  number       = {3},
  pages        = {239--242},
  publisher    = {Elsevier},
  series       = {Journal of Clinical Virology},
  title        = {Gastroenteritis and the novel picornaviruses aichi virus, cosavirus, saffold virus, and salivirus in young children},
  url          = {http://dx.doi.org/10.1016/j.jcv.2013.03.015},
  volume       = {57},
  year         = {2013},
}