Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Case Report: "Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy"

van Verseveld, M ; Koens, L H ; de Koning, Tom J LU ; Derikx, R L E and van Waarde, J A (2021) In Frontiers in Psychiatry 12. p.1-4
Abstract

We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary ECT-patient, NP-C was diagnosed not until after the first ECT-course when initial psychopharmacology for catatonia had failed and antipsychotics and benzodiazepines showed significant side-effects. Clinicians should be aware of NP-C in patients referred for ECT, especially in the case of treatment resistance, neurological symptoms and intolerance... (More)

We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary ECT-patient, NP-C was diagnosed not until after the first ECT-course when initial psychopharmacology for catatonia had failed and antipsychotics and benzodiazepines showed significant side-effects. Clinicians should be aware of NP-C in patients referred for ECT, especially in the case of treatment resistance, neurological symptoms and intolerance of psychopharmacological drugs. As was shown in our NP-C patient, ECT can be repeatedly effective for catatonic features. In the literature, effectiveness of ECT in patients with NP-C has sparsely been reported. This case demonstrates that detection of NP-C is beneficial for patients because more optimal treatment with ECT can be provided earlier without further exposure to side-effects.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Frontiers in Psychiatry
volume
12
article number
745734
pages
1 - 4
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85118694887
  • pmid:34744838
ISSN
1664-0640
DOI
10.3389/fpsyt.2021.745734
language
English
LU publication?
yes
additional info
Copyright © 2021 van Verseveld, Koens, de Koning, Derikx and van Waarde.
id
3a172bbc-2edf-4bbb-b842-4040bf97f34a
date added to LUP
2021-11-16 20:02:33
date last changed
2025-10-14 09:34:25
@article{3a172bbc-2edf-4bbb-b842-4040bf97f34a,
  abstract     = {{<p>We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary ECT-patient, NP-C was diagnosed not until after the first ECT-course when initial psychopharmacology for catatonia had failed and antipsychotics and benzodiazepines showed significant side-effects. Clinicians should be aware of NP-C in patients referred for ECT, especially in the case of treatment resistance, neurological symptoms and intolerance of psychopharmacological drugs. As was shown in our NP-C patient, ECT can be repeatedly effective for catatonic features. In the literature, effectiveness of ECT in patients with NP-C has sparsely been reported. This case demonstrates that detection of NP-C is beneficial for patients because more optimal treatment with ECT can be provided earlier without further exposure to side-effects.</p>}},
  author       = {{van Verseveld, M and Koens, L H and de Koning, Tom J and Derikx, R L E and van Waarde, J A}},
  issn         = {{1664-0640}},
  language     = {{eng}},
  pages        = {{1--4}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Psychiatry}},
  title        = {{Case Report: "Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy"}},
  url          = {{http://dx.doi.org/10.3389/fpsyt.2021.745734}},
  doi          = {{10.3389/fpsyt.2021.745734}},
  volume       = {{12}},
  year         = {{2021}},
}