Case Report: "Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy"
(2021) In Frontiers in Psychiatry 12. p.1-4- Abstract
We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary ECT-patient, NP-C was diagnosed not until after the first ECT-course when initial psychopharmacology for catatonia had failed and antipsychotics and benzodiazepines showed significant side-effects. Clinicians should be aware of NP-C in patients referred for ECT, especially in the case of treatment resistance, neurological symptoms and intolerance... (More)
We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary ECT-patient, NP-C was diagnosed not until after the first ECT-course when initial psychopharmacology for catatonia had failed and antipsychotics and benzodiazepines showed significant side-effects. Clinicians should be aware of NP-C in patients referred for ECT, especially in the case of treatment resistance, neurological symptoms and intolerance of psychopharmacological drugs. As was shown in our NP-C patient, ECT can be repeatedly effective for catatonic features. In the literature, effectiveness of ECT in patients with NP-C has sparsely been reported. This case demonstrates that detection of NP-C is beneficial for patients because more optimal treatment with ECT can be provided earlier without further exposure to side-effects.
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- author
- van Verseveld, M ; Koens, L H ; de Koning, Tom J LU ; Derikx, R L E and van Waarde, J A
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Frontiers in Psychiatry
- volume
- 12
- article number
- 745734
- pages
- 1 - 4
- publisher
- Frontiers Media S. A.
- external identifiers
-
- pmid:34744838
- scopus:85118694887
- ISSN
- 1664-0640
- DOI
- 10.3389/fpsyt.2021.745734
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2021 van Verseveld, Koens, de Koning, Derikx and van Waarde.
- id
- 3a172bbc-2edf-4bbb-b842-4040bf97f34a
- date added to LUP
- 2021-11-16 20:02:33
- date last changed
- 2024-08-11 01:24:24
@article{3a172bbc-2edf-4bbb-b842-4040bf97f34a, abstract = {{<p>We describe a case of an adolescent male with Niemann-Pick Type C (NP-C), a neurodegenerative lysosomal lipid storage disorder, who presented with recurrent catatonia which required repeated treatment with electroconvulsive therapy (ECT). During the ECT-course, seizure threshold increased substantially, leading to questions about the influence of NP-C on neuronal excitability. In this exemplary ECT-patient, NP-C was diagnosed not until after the first ECT-course when initial psychopharmacology for catatonia had failed and antipsychotics and benzodiazepines showed significant side-effects. Clinicians should be aware of NP-C in patients referred for ECT, especially in the case of treatment resistance, neurological symptoms and intolerance of psychopharmacological drugs. As was shown in our NP-C patient, ECT can be repeatedly effective for catatonic features. In the literature, effectiveness of ECT in patients with NP-C has sparsely been reported. This case demonstrates that detection of NP-C is beneficial for patients because more optimal treatment with ECT can be provided earlier without further exposure to side-effects.</p>}}, author = {{van Verseveld, M and Koens, L H and de Koning, Tom J and Derikx, R L E and van Waarde, J A}}, issn = {{1664-0640}}, language = {{eng}}, pages = {{1--4}}, publisher = {{Frontiers Media S. A.}}, series = {{Frontiers in Psychiatry}}, title = {{Case Report: "Niemann-Pick Disease Type C in a Catatonic Patient Treated With Electroconvulsive Therapy"}}, url = {{http://dx.doi.org/10.3389/fpsyt.2021.745734}}, doi = {{10.3389/fpsyt.2021.745734}}, volume = {{12}}, year = {{2021}}, }