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Serious invasive Saffold virus infections in children, 2009

Nielsen, Alex Christian Yde ; Böttiger, Blenda LU ; Banner, Jytte ; Hoffmann, Thomas and Nielsen, Lars Peter (2012) In Emerging Infectious Diseases 18(1). p.7-12
Abstract

The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been convincingly associated with disease in humans. To study a possible association between SAFV and infections in the human central nervous system, we designed a real-time PCR for SAFV and tested cerebrospinal fluid (CSF) samples from children <4 years of age. SAFV was detected in 2 children: in the CSF and a fecal sample from 1 child with monosymptomatic ataxia caused by cerebellitis; and in the CSF, blood, and myocardium of another child who died suddenly with no history of illness. Virus from each child was... (More)

The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been convincingly associated with disease in humans. To study a possible association between SAFV and infections in the human central nervous system, we designed a real-time PCR for SAFV and tested cerebrospinal fluid (CSF) samples from children <4 years of age. SAFV was detected in 2 children: in the CSF and a fecal sample from 1 child with monosymptomatic ataxia caused by cerebellitis; and in the CSF, blood, and myocardium of another child who died suddenly with no history of illness. Virus from each child was sequenced and shown to be SAFV type 2. These findings demonstrate that SAFV can cause serious invasive infection in children.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Cardiovirus/classification, Cardiovirus Infections/cerebrospinal fluid, Central Nervous System Infections/pathology, Child, Preschool, Fatal Outcome, Feces/virology, Female, Genome, Viral, Humans, Infant, Male, Phylogeny, Real-Time Polymerase Chain Reaction
in
Emerging Infectious Diseases
volume
18
issue
1
pages
7 - 12
publisher
Centers for Disease Control and Prevention
external identifiers
  • scopus:84856575876
  • pmid:22261113
ISSN
1080-6040
DOI
10.3201/eid1801.110725
language
English
LU publication?
no
id
3a64782d-44dc-49b7-8044-10cdeeae60da
date added to LUP
2019-05-02 14:16:43
date last changed
2024-06-25 11:16:55
@article{3a64782d-44dc-49b7-8044-10cdeeae60da,
  abstract     = {{<p>The first human virus in the genus Cardiovirus was described in 2007 and named Saffold virus (SAFV). Cardioviruses can cause severe infections of the myocardium and central nervous system in animals, but SAFV has not yet been convincingly associated with disease in humans. To study a possible association between SAFV and infections in the human central nervous system, we designed a real-time PCR for SAFV and tested cerebrospinal fluid (CSF) samples from children &lt;4 years of age. SAFV was detected in 2 children: in the CSF and a fecal sample from 1 child with monosymptomatic ataxia caused by cerebellitis; and in the CSF, blood, and myocardium of another child who died suddenly with no history of illness. Virus from each child was sequenced and shown to be SAFV type 2. These findings demonstrate that SAFV can cause serious invasive infection in children.</p>}},
  author       = {{Nielsen, Alex Christian Yde and Böttiger, Blenda and Banner, Jytte and Hoffmann, Thomas and Nielsen, Lars Peter}},
  issn         = {{1080-6040}},
  keywords     = {{Cardiovirus/classification; Cardiovirus Infections/cerebrospinal fluid; Central Nervous System Infections/pathology; Child, Preschool; Fatal Outcome; Feces/virology; Female; Genome, Viral; Humans; Infant; Male; Phylogeny; Real-Time Polymerase Chain Reaction}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{7--12}},
  publisher    = {{Centers for Disease Control and Prevention}},
  series       = {{Emerging Infectious Diseases}},
  title        = {{Serious invasive Saffold virus infections in children, 2009}},
  url          = {{http://dx.doi.org/10.3201/eid1801.110725}},
  doi          = {{10.3201/eid1801.110725}},
  volume       = {{18}},
  year         = {{2012}},
}