Forecasting memory function in aging : pattern-completion ability and hippocampal activity relate to visuospatial functioning over 25 years
(2020) In Neurobiology of Aging 94. p.217-226- Abstract
Heterogeneity in episodic memory functioning in aging was assessed with a pattern-completion functional magnetic resonance imaging task that required reactivation of well-consolidated face-name memory traces from fragmented (partial) or morphed (noisy) face cues. About half of the examined individuals (N = 101) showed impaired (chance) performance on fragmented faces despite intact performance on complete and morphed faces, and they did not show a pattern-completion response in hippocampus or the examined subfields (CA1, CA23, DGCA4). This apparent pattern-completion deficit could not be explained by differential hippocampal atrophy. Instead, the impaired group displayed lower cortical volumes, accelerated reduction in mini-mental state... (More)
Heterogeneity in episodic memory functioning in aging was assessed with a pattern-completion functional magnetic resonance imaging task that required reactivation of well-consolidated face-name memory traces from fragmented (partial) or morphed (noisy) face cues. About half of the examined individuals (N = 101) showed impaired (chance) performance on fragmented faces despite intact performance on complete and morphed faces, and they did not show a pattern-completion response in hippocampus or the examined subfields (CA1, CA23, DGCA4). This apparent pattern-completion deficit could not be explained by differential hippocampal atrophy. Instead, the impaired group displayed lower cortical volumes, accelerated reduction in mini-mental state examination scores, and lower general cognitive function as defined by longitudinal measures of visuospatial functioning and speed-of-processing. In the full sample, inter-individual differences in visuospatial functioning predicted performance on fragmented faces and hippocampal CA23 subfield activity over 25 years. These findings suggest that visuospatial functioning in middle age can forecast pattern-completion deficits in aging.
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- author
- Nyberg, Lars ; Grande, Xenia ; Andersson, Micael ; Berron, David LU ; Lundquist, Anders ; Stiernstedt, Mikael ; Fjell, Anders ; Walhovd, Kristine and Orädd, Greger
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Episodic memory, General cognitive function, Hippocampus, Subfields
- in
- Neurobiology of Aging
- volume
- 94
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:32650185
- scopus:85087497619
- ISSN
- 0197-4580
- DOI
- 10.1016/j.neurobiolaging.2020.06.005
- language
- English
- LU publication?
- yes
- id
- 3a6c84be-e9ce-4a0c-b642-0728a3bc6c57
- date added to LUP
- 2020-07-14 12:13:36
- date last changed
- 2024-03-20 13:02:44
@article{3a6c84be-e9ce-4a0c-b642-0728a3bc6c57,
abstract = {{<p>Heterogeneity in episodic memory functioning in aging was assessed with a pattern-completion functional magnetic resonance imaging task that required reactivation of well-consolidated face-name memory traces from fragmented (partial) or morphed (noisy) face cues. About half of the examined individuals (N = 101) showed impaired (chance) performance on fragmented faces despite intact performance on complete and morphed faces, and they did not show a pattern-completion response in hippocampus or the examined subfields (CA1, CA23, DGCA4). This apparent pattern-completion deficit could not be explained by differential hippocampal atrophy. Instead, the impaired group displayed lower cortical volumes, accelerated reduction in mini-mental state examination scores, and lower general cognitive function as defined by longitudinal measures of visuospatial functioning and speed-of-processing. In the full sample, inter-individual differences in visuospatial functioning predicted performance on fragmented faces and hippocampal CA23 subfield activity over 25 years. These findings suggest that visuospatial functioning in middle age can forecast pattern-completion deficits in aging.</p>}},
author = {{Nyberg, Lars and Grande, Xenia and Andersson, Micael and Berron, David and Lundquist, Anders and Stiernstedt, Mikael and Fjell, Anders and Walhovd, Kristine and Orädd, Greger}},
issn = {{0197-4580}},
keywords = {{Episodic memory; General cognitive function; Hippocampus; Subfields}},
language = {{eng}},
pages = {{217--226}},
publisher = {{Elsevier}},
series = {{Neurobiology of Aging}},
title = {{Forecasting memory function in aging : pattern-completion ability and hippocampal activity relate to visuospatial functioning over 25 years}},
url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2020.06.005}},
doi = {{10.1016/j.neurobiolaging.2020.06.005}},
volume = {{94}},
year = {{2020}},
}