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Test-retest repeatability of human speech biomarkers from static and real-time dynamic magnetic resonance imaging

Töger, Johannes LU ; Sorensen, Tanner ; Somandepalli, Krishna ; Toutios, Asterios ; Lingala, Sajan Goud ; Narayanan, Shrikanth and Nayak, Krishna (2017) In Journal of the Acoustical Society of America 141(5). p.3323-3336
Abstract

Static anatomical and real-time dynamic magnetic resonance imaging (RT-MRI) of the upper airway is a valuable method for studying speech production in research and clinical settings. The test-retest repeatability of quantitative imaging biomarkers is an important parameter, since it limits the effect sizes and intragroup differences that can be studied. Therefore, this study aims to present a framework for determining the test-retest repeatability of quantitative speech biomarkers from static MRI and RT-MRI, and apply the framework to healthy volunteers. Subjects (n = 8, 4 females, 4 males) are imaged in two scans on the same day, including static images and dynamic RT-MRI of speech tasks. The inter-study agreement is quantified using... (More)

Static anatomical and real-time dynamic magnetic resonance imaging (RT-MRI) of the upper airway is a valuable method for studying speech production in research and clinical settings. The test-retest repeatability of quantitative imaging biomarkers is an important parameter, since it limits the effect sizes and intragroup differences that can be studied. Therefore, this study aims to present a framework for determining the test-retest repeatability of quantitative speech biomarkers from static MRI and RT-MRI, and apply the framework to healthy volunteers. Subjects (n = 8, 4 females, 4 males) are imaged in two scans on the same day, including static images and dynamic RT-MRI of speech tasks. The inter-study agreement is quantified using intraclass correlation coefficient (ICC) and mean within-subject standard deviation (σe). Inter-study agreement is strong to very strong for static measures (ICC: min/median/max 0.71/0.89/0.98, σe: 0.90/2.20/6.72 mm), poor to strong for dynamic RT-MRI measures of articulator motion range (ICC: 0.26/0.75/0.90, σe: 1.6/2.5/3.6 mm), and poor to very strong for velocities (ICC: 0.21/0.56/0.93, σe: 2.2/4.4/16.7 cm/s). In conclusion, this study characterizes repeatability of static and dynamic MRI-derived speech biomarkers using state-of-the-art imaging. The introduced framework can be used to guide future development of speech biomarkers. Test-retest MRI data are provided free for research use.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Journal of the Acoustical Society of America
volume
141
issue
5
article number
4983081
pages
3323 - 3336
publisher
American Institute of Physics (AIP)
external identifiers
  • scopus:85029908467
ISSN
0001-4966
DOI
10.1121/1.4983081
language
English
LU publication?
no
id
3a827547-e92a-4877-96f4-202fdfa5116c
date added to LUP
2019-05-14 16:08:56
date last changed
2022-04-18 04:59:23
@article{3a827547-e92a-4877-96f4-202fdfa5116c,
  abstract     = {{<p>Static anatomical and real-time dynamic magnetic resonance imaging (RT-MRI) of the upper airway is a valuable method for studying speech production in research and clinical settings. The test-retest repeatability of quantitative imaging biomarkers is an important parameter, since it limits the effect sizes and intragroup differences that can be studied. Therefore, this study aims to present a framework for determining the test-retest repeatability of quantitative speech biomarkers from static MRI and RT-MRI, and apply the framework to healthy volunteers. Subjects (n = 8, 4 females, 4 males) are imaged in two scans on the same day, including static images and dynamic RT-MRI of speech tasks. The inter-study agreement is quantified using intraclass correlation coefficient (ICC) and mean within-subject standard deviation (σ<sub>e</sub>). Inter-study agreement is strong to very strong for static measures (ICC: min/median/max 0.71/0.89/0.98, σ<sub>e</sub>: 0.90/2.20/6.72 mm), poor to strong for dynamic RT-MRI measures of articulator motion range (ICC: 0.26/0.75/0.90, σ<sub>e</sub>: 1.6/2.5/3.6 mm), and poor to very strong for velocities (ICC: 0.21/0.56/0.93, σ<sub>e</sub>: 2.2/4.4/16.7 cm/s). In conclusion, this study characterizes repeatability of static and dynamic MRI-derived speech biomarkers using state-of-the-art imaging. The introduced framework can be used to guide future development of speech biomarkers. Test-retest MRI data are provided free for research use.</p>}},
  author       = {{Töger, Johannes and Sorensen, Tanner and Somandepalli, Krishna and Toutios, Asterios and Lingala, Sajan Goud and Narayanan, Shrikanth and Nayak, Krishna}},
  issn         = {{0001-4966}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{5}},
  pages        = {{3323--3336}},
  publisher    = {{American Institute of Physics (AIP)}},
  series       = {{Journal of the Acoustical Society of America}},
  title        = {{Test-retest repeatability of human speech biomarkers from static and real-time dynamic magnetic resonance imaging}},
  url          = {{http://dx.doi.org/10.1121/1.4983081}},
  doi          = {{10.1121/1.4983081}},
  volume       = {{141}},
  year         = {{2017}},
}