Test-retest repeatability of human speech biomarkers from static and real-time dynamic magnetic resonance imaging
(2017) In Journal of the Acoustical Society of America 141(5). p.3323-3336- Abstract
Static anatomical and real-time dynamic magnetic resonance imaging (RT-MRI) of the upper airway is a valuable method for studying speech production in research and clinical settings. The test-retest repeatability of quantitative imaging biomarkers is an important parameter, since it limits the effect sizes and intragroup differences that can be studied. Therefore, this study aims to present a framework for determining the test-retest repeatability of quantitative speech biomarkers from static MRI and RT-MRI, and apply the framework to healthy volunteers. Subjects (n = 8, 4 females, 4 males) are imaged in two scans on the same day, including static images and dynamic RT-MRI of speech tasks. The inter-study agreement is quantified using... (More)
Static anatomical and real-time dynamic magnetic resonance imaging (RT-MRI) of the upper airway is a valuable method for studying speech production in research and clinical settings. The test-retest repeatability of quantitative imaging biomarkers is an important parameter, since it limits the effect sizes and intragroup differences that can be studied. Therefore, this study aims to present a framework for determining the test-retest repeatability of quantitative speech biomarkers from static MRI and RT-MRI, and apply the framework to healthy volunteers. Subjects (n = 8, 4 females, 4 males) are imaged in two scans on the same day, including static images and dynamic RT-MRI of speech tasks. The inter-study agreement is quantified using intraclass correlation coefficient (ICC) and mean within-subject standard deviation (σe). Inter-study agreement is strong to very strong for static measures (ICC: min/median/max 0.71/0.89/0.98, σe: 0.90/2.20/6.72 mm), poor to strong for dynamic RT-MRI measures of articulator motion range (ICC: 0.26/0.75/0.90, σe: 1.6/2.5/3.6 mm), and poor to very strong for velocities (ICC: 0.21/0.56/0.93, σe: 2.2/4.4/16.7 cm/s). In conclusion, this study characterizes repeatability of static and dynamic MRI-derived speech biomarkers using state-of-the-art imaging. The introduced framework can be used to guide future development of speech biomarkers. Test-retest MRI data are provided free for research use.
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- author
- Töger, Johannes LU ; Sorensen, Tanner ; Somandepalli, Krishna ; Toutios, Asterios ; Lingala, Sajan Goud ; Narayanan, Shrikanth and Nayak, Krishna
- publishing date
- 2017-05-01
- type
- Contribution to journal
- publication status
- published
- in
- Journal of the Acoustical Society of America
- volume
- 141
- issue
- 5
- article number
- 4983081
- pages
- 3323 - 3336
- publisher
- American Institute of Physics (AIP)
- external identifiers
-
- scopus:85029908467
- ISSN
- 0001-4966
- DOI
- 10.1121/1.4983081
- language
- English
- LU publication?
- no
- id
- 3a827547-e92a-4877-96f4-202fdfa5116c
- date added to LUP
- 2019-05-14 16:08:56
- date last changed
- 2022-04-18 04:59:23
@article{3a827547-e92a-4877-96f4-202fdfa5116c, abstract = {{<p>Static anatomical and real-time dynamic magnetic resonance imaging (RT-MRI) of the upper airway is a valuable method for studying speech production in research and clinical settings. The test-retest repeatability of quantitative imaging biomarkers is an important parameter, since it limits the effect sizes and intragroup differences that can be studied. Therefore, this study aims to present a framework for determining the test-retest repeatability of quantitative speech biomarkers from static MRI and RT-MRI, and apply the framework to healthy volunteers. Subjects (n = 8, 4 females, 4 males) are imaged in two scans on the same day, including static images and dynamic RT-MRI of speech tasks. The inter-study agreement is quantified using intraclass correlation coefficient (ICC) and mean within-subject standard deviation (σ<sub>e</sub>). Inter-study agreement is strong to very strong for static measures (ICC: min/median/max 0.71/0.89/0.98, σ<sub>e</sub>: 0.90/2.20/6.72 mm), poor to strong for dynamic RT-MRI measures of articulator motion range (ICC: 0.26/0.75/0.90, σ<sub>e</sub>: 1.6/2.5/3.6 mm), and poor to very strong for velocities (ICC: 0.21/0.56/0.93, σ<sub>e</sub>: 2.2/4.4/16.7 cm/s). In conclusion, this study characterizes repeatability of static and dynamic MRI-derived speech biomarkers using state-of-the-art imaging. The introduced framework can be used to guide future development of speech biomarkers. Test-retest MRI data are provided free for research use.</p>}}, author = {{Töger, Johannes and Sorensen, Tanner and Somandepalli, Krishna and Toutios, Asterios and Lingala, Sajan Goud and Narayanan, Shrikanth and Nayak, Krishna}}, issn = {{0001-4966}}, language = {{eng}}, month = {{05}}, number = {{5}}, pages = {{3323--3336}}, publisher = {{American Institute of Physics (AIP)}}, series = {{Journal of the Acoustical Society of America}}, title = {{Test-retest repeatability of human speech biomarkers from static and real-time dynamic magnetic resonance imaging}}, url = {{http://dx.doi.org/10.1121/1.4983081}}, doi = {{10.1121/1.4983081}}, volume = {{141}}, year = {{2017}}, }