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Content of adenosine 3′:5′-cyclic monophosphate in the pancreatic islets of mice with a hereditary defect of insulin secretion

Boquist, Lennart ; Hellman, Bo ; Lernmark, Åke LU orcid and Täljedal, Inge Bert (1974) In Biochemical and Biophysical Research Communications 60(4). p.1391-1396
Abstract

Glucose (20 mM) released insulin from pancreatic islets of C57BL 6J- db2J db2J mice, the response being potentiated by 1 mM 3-isobutyl-1-methylxanthine. Islets of C57BL KsJ- db db mice failed to respond to glucose and released only little insulin when challenged with both glucose and methylxanthine. After incubation with 0 or 20 mM glucose alone the islet content of adenosine 3′:5′-cyclic monophosphate did not differ between the two types of mice or between glucose concentrations. 3-Isobutyl-1-methylxanthine increased the islet adenosine 3′:5′-cyclic monophosphate markedly in 6J- db2J db2J mice but not significantly in KsJ- db db mice.

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author
; ; and
publishing date
type
Contribution to journal
publication status
published
in
Biochemical and Biophysical Research Communications
volume
60
issue
4
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:0016173240
  • pmid:4370927
ISSN
0006-291X
DOI
10.1016/0006-291X(74)90352-0
language
English
LU publication?
no
id
3aa478ed-2836-49ce-aab2-629345378a9e
date added to LUP
2019-09-18 12:18:36
date last changed
2024-03-13 08:18:57
@article{3aa478ed-2836-49ce-aab2-629345378a9e,
  abstract     = {{<p>Glucose (20 mM) released insulin from pancreatic islets of C57BL 6J- db<sup>2J</sup> db<sup>2J</sup> mice, the response being potentiated by 1 mM 3-isobutyl-1-methylxanthine. Islets of C57BL KsJ- db db mice failed to respond to glucose and released only little insulin when challenged with both glucose and methylxanthine. After incubation with 0 or 20 mM glucose alone the islet content of adenosine 3′:5′-cyclic monophosphate did not differ between the two types of mice or between glucose concentrations. 3-Isobutyl-1-methylxanthine increased the islet adenosine 3′:5′-cyclic monophosphate markedly in 6J- db<sup>2J</sup> db<sup>2J</sup> mice but not significantly in KsJ- db db mice.</p>}},
  author       = {{Boquist, Lennart and Hellman, Bo and Lernmark, Åke and Täljedal, Inge Bert}},
  issn         = {{0006-291X}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{4}},
  pages        = {{1391--1396}},
  publisher    = {{Elsevier}},
  series       = {{Biochemical and Biophysical Research Communications}},
  title        = {{Content of adenosine 3′:5′-cyclic monophosphate in the pancreatic islets of mice with a hereditary defect of insulin secretion}},
  url          = {{http://dx.doi.org/10.1016/0006-291X(74)90352-0}},
  doi          = {{10.1016/0006-291X(74)90352-0}},
  volume       = {{60}},
  year         = {{1974}},
}