Content of adenosine 3′:5′-cyclic monophosphate in the pancreatic islets of mice with a hereditary defect of insulin secretion
(1974) In Biochemical and Biophysical Research Communications 60(4). p.1391-1396- Abstract
Glucose (20 mM) released insulin from pancreatic islets of C57BL 6J- db2J db2J mice, the response being potentiated by 1 mM 3-isobutyl-1-methylxanthine. Islets of C57BL KsJ- db db mice failed to respond to glucose and released only little insulin when challenged with both glucose and methylxanthine. After incubation with 0 or 20 mM glucose alone the islet content of adenosine 3′:5′-cyclic monophosphate did not differ between the two types of mice or between glucose concentrations. 3-Isobutyl-1-methylxanthine increased the islet adenosine 3′:5′-cyclic monophosphate markedly in 6J- db2J db2J mice but not significantly in KsJ- db db mice.
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https://lup.lub.lu.se/record/3aa478ed-2836-49ce-aab2-629345378a9e
- author
- Boquist, Lennart ; Hellman, Bo ; Lernmark, Åke LU and Täljedal, Inge Bert
- publishing date
- 1974-10-23
- type
- Contribution to journal
- publication status
- published
- in
- Biochemical and Biophysical Research Communications
- volume
- 60
- issue
- 4
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:4370927
- scopus:0016173240
- ISSN
- 0006-291X
- DOI
- 10.1016/0006-291X(74)90352-0
- language
- English
- LU publication?
- no
- id
- 3aa478ed-2836-49ce-aab2-629345378a9e
- date added to LUP
- 2019-09-18 12:18:36
- date last changed
- 2024-03-13 08:18:57
@article{3aa478ed-2836-49ce-aab2-629345378a9e, abstract = {{<p>Glucose (20 mM) released insulin from pancreatic islets of C57BL 6J- db<sup>2J</sup> db<sup>2J</sup> mice, the response being potentiated by 1 mM 3-isobutyl-1-methylxanthine. Islets of C57BL KsJ- db db mice failed to respond to glucose and released only little insulin when challenged with both glucose and methylxanthine. After incubation with 0 or 20 mM glucose alone the islet content of adenosine 3′:5′-cyclic monophosphate did not differ between the two types of mice or between glucose concentrations. 3-Isobutyl-1-methylxanthine increased the islet adenosine 3′:5′-cyclic monophosphate markedly in 6J- db<sup>2J</sup> db<sup>2J</sup> mice but not significantly in KsJ- db db mice.</p>}}, author = {{Boquist, Lennart and Hellman, Bo and Lernmark, Åke and Täljedal, Inge Bert}}, issn = {{0006-291X}}, language = {{eng}}, month = {{10}}, number = {{4}}, pages = {{1391--1396}}, publisher = {{Elsevier}}, series = {{Biochemical and Biophysical Research Communications}}, title = {{Content of adenosine 3′:5′-cyclic monophosphate in the pancreatic islets of mice with a hereditary defect of insulin secretion}}, url = {{http://dx.doi.org/10.1016/0006-291X(74)90352-0}}, doi = {{10.1016/0006-291X(74)90352-0}}, volume = {{60}}, year = {{1974}}, }