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Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes : In search of the culprit allergen

Schuttelaar, Marie-Louise; Meijer, Joost M.; Engfeldt, Malin LU ; Lapeere, Hilde; Goossens, An; Bruze, Magnus LU ; Persson, Christina LU and Bergendorff, Ola LU (2017) In Contact Dermatitis
Abstract

Background: During rubber vulcanization, new compounds can be formed. Objectives: To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). Methods: A female presented with eczema on her feet after wearing Sperry Top Sider® canvas sneakers. Patch testing was performed with the European baseline series, additional series, shoe materials, and extracts of shoe materials. Thin-layer chromatography (TLC) was performed for additional patch testing, and high-performance liquid chromatography and gas chromatography-mass spectometry were used for chemical analysis. Results: Positive reactions were found to thiuram mix (+),... (More)

Background: During rubber vulcanization, new compounds can be formed. Objectives: To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). Methods: A female presented with eczema on her feet after wearing Sperry Top Sider® canvas sneakers. Patch testing was performed with the European baseline series, additional series, shoe materials, and extracts of shoe materials. Thin-layer chromatography (TLC) was performed for additional patch testing, and high-performance liquid chromatography and gas chromatography-mass spectometry were used for chemical analysis. Results: Positive reactions were found to thiuram mix (+), tetramethylthiuram monosulfide (TMTM) (+), shoe material (+), and shoe extracts in eth. (++) and acetone (+). The extracts did not contain TMTM or other components of thiuram mix. TLC strips yielded a positive reaction (+) to one spot, whereas chemical analysis gave a negative result. Thereafter, a similar sneaker from another patient with shoe dermatitis was analysed, and DMBTS was identified. New extracts of the shoe of our first patient were then also shown to contain DMTBS. DMTBS as culprit allergen was confirmed by positive patch testing with a dilution series with DMTBS. Conclusion: DMBTS was identified as the culprit allergen in shoe dermatitis, giving rise to compound allergy. The positive reaction to TMTM was considered to represent cross-reactivity.

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organization
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publication status
epub
subject
keywords
Allergic contact dermatitis, CAS no. 3432-25-5, Case report, Dimethylthiocarbamylbenzothiazole sulfide, DMTBS, Gas chromatography-mass spectrometry, Shoe dermatitis, Thin-layer chromatography, Thiurams, Ultrasonic bath extract
in
Contact Dermatitis
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85026764957
ISSN
0105-1873
DOI
10.1111/cod.12857
language
English
LU publication?
yes
id
3aa62959-1f2a-49aa-a8a6-ae5b245104f5
date added to LUP
2017-08-30 15:17:30
date last changed
2017-08-31 03:00:03
@article{3aa62959-1f2a-49aa-a8a6-ae5b245104f5,
  abstract     = {<p>Background: During rubber vulcanization, new compounds can be formed. Objectives: To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). Methods: A female presented with eczema on her feet after wearing Sperry Top Sider® canvas sneakers. Patch testing was performed with the European baseline series, additional series, shoe materials, and extracts of shoe materials. Thin-layer chromatography (TLC) was performed for additional patch testing, and high-performance liquid chromatography and gas chromatography-mass spectometry were used for chemical analysis. Results: Positive reactions were found to thiuram mix (+), tetramethylthiuram monosulfide (TMTM) (+), shoe material (+), and shoe extracts in eth. (++) and acetone (+). The extracts did not contain TMTM or other components of thiuram mix. TLC strips yielded a positive reaction (+) to one spot, whereas chemical analysis gave a negative result. Thereafter, a similar sneaker from another patient with shoe dermatitis was analysed, and DMBTS was identified. New extracts of the shoe of our first patient were then also shown to contain DMTBS. DMTBS as culprit allergen was confirmed by positive patch testing with a dilution series with DMTBS. Conclusion: DMBTS was identified as the culprit allergen in shoe dermatitis, giving rise to compound allergy. The positive reaction to TMTM was considered to represent cross-reactivity.</p>},
  author       = {Schuttelaar, Marie-Louise and Meijer, Joost M. and Engfeldt, Malin and Lapeere, Hilde and Goossens, An and Bruze, Magnus and Persson, Christina and Bergendorff, Ola},
  issn         = {0105-1873},
  keyword      = {Allergic contact dermatitis,CAS no. 3432-25-5,Case report,Dimethylthiocarbamylbenzothiazole sulfide,DMTBS,Gas chromatography-mass spectrometry,Shoe dermatitis,Thin-layer chromatography,Thiurams,Ultrasonic bath extract},
  language     = {eng},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Allergic contact dermatitis caused by dimethylthiocarbamylbenzothiazole sulfide (DMTBS) in canvas shoes : In search of the culprit allergen},
  url          = {http://dx.doi.org/10.1111/cod.12857},
  year         = {2017},
}