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The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up

Svensson, Thomas LU ; Sawada, Norie; Mimura, Masaru; Nozaki, Shoko; Shikimoto, Ryo and Tsugane, Shoichiro (2019) In Translational Psychiatry 9(1).
Abstract

A third of dementia cases could be attributable to modifiable risk-factors. Midlife high-density lipoprotein cholesterol (HDL-C) is a measure which could help identify individuals at reduced risk of developing age-related cognitive decline. The Japan Public Health Centre-based prospective (JPHC) Study is a large population-based cohort which started in 1990. This study included 1299 participants from Saku area in Nagano prefecture. Participants had HDL-C measured in 1995-1996, and underwent a mental health screening in 2014-2015. Of these, 1114 participants were included in MCI analyses, and 781 participants were included in dementia analyses. Logistic regression models were used to determine odds ratios (OR) and 95% confidence... (More)

A third of dementia cases could be attributable to modifiable risk-factors. Midlife high-density lipoprotein cholesterol (HDL-C) is a measure which could help identify individuals at reduced risk of developing age-related cognitive decline. The Japan Public Health Centre-based prospective (JPHC) Study is a large population-based cohort which started in 1990. This study included 1299 participants from Saku area in Nagano prefecture. Participants had HDL-C measured in 1995-1996, and underwent a mental health screening in 2014-2015. Of these, 1114 participants were included in MCI analyses, and 781 participants were included in dementia analyses. Logistic regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI) for the association between HDL-C quartiles and MCI and dementia, respectively. For dementia analysis, quartiles 2-4 were collapsed due to low number of cases. Missing data was addressed through multiple imputations. There were 386 cases of MCI and 53 cases of dementia. Compared to the lowest HDL-C quartile, the highest HDL-C quartile was significantly inversely associated with MCI (OR = 0.47, 95% CI, 0.28-0.79) in the multivariable analysis. High HDL-C (quartiles 2-4) was inversely associated with dementia compared to low HDL-C (quartile 1) (OR = 0.37, 95% CI, 0.16-0.88). This study has found that high midlife HDL-C levels are inversely associated with both late-life MCI and dementia in a Japanese population.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Translational Psychiatry
volume
9
issue
1
publisher
Nature Publishing Group
external identifiers
  • scopus:85060167977
ISSN
2158-3188
DOI
10.1038/s41398-018-0336-y
language
English
LU publication?
yes
id
3aa77148-277f-45f6-9066-b3dc717e4ea9
date added to LUP
2019-01-22 21:34:35
date last changed
2019-02-20 11:43:59
@article{3aa77148-277f-45f6-9066-b3dc717e4ea9,
  abstract     = {<p>A third of dementia cases could be attributable to modifiable risk-factors. Midlife high-density lipoprotein cholesterol (HDL-C) is a measure which could help identify individuals at reduced risk of developing age-related cognitive decline. The Japan Public Health Centre-based prospective (JPHC) Study is a large population-based cohort which started in 1990. This study included 1299 participants from Saku area in Nagano prefecture. Participants had HDL-C measured in 1995-1996, and underwent a mental health screening in 2014-2015. Of these, 1114 participants were included in MCI analyses, and 781 participants were included in dementia analyses. Logistic regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI) for the association between HDL-C quartiles and MCI and dementia, respectively. For dementia analysis, quartiles 2-4 were collapsed due to low number of cases. Missing data was addressed through multiple imputations. There were 386 cases of MCI and 53 cases of dementia. Compared to the lowest HDL-C quartile, the highest HDL-C quartile was significantly inversely associated with MCI (OR = 0.47, 95% CI, 0.28-0.79) in the multivariable analysis. High HDL-C (quartiles 2-4) was inversely associated with dementia compared to low HDL-C (quartile 1) (OR = 0.37, 95% CI, 0.16-0.88). This study has found that high midlife HDL-C levels are inversely associated with both late-life MCI and dementia in a Japanese population.</p>},
  articleno    = {26},
  author       = {Svensson, Thomas and Sawada, Norie and Mimura, Masaru and Nozaki, Shoko and Shikimoto, Ryo and Tsugane, Shoichiro},
  issn         = {2158-3188},
  language     = {eng},
  month        = {01},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Translational Psychiatry},
  title        = {The association between midlife serum high-density lipoprotein and mild cognitive impairment and dementia after 19 years of follow-up},
  url          = {http://dx.doi.org/10.1038/s41398-018-0336-y},
  volume       = {9},
  year         = {2019},
}