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Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia

Richter, Ulrike LU ; Halje, Pär LU and Petersson, Per LU (2013) In Reviews in the Neurosciences 24(4). p.415-429
Abstract
A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the... (More)
A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
basal ganglia, dopamine, motor cortex, neuronal circuits, oscillations, Parkinson's disease
in
Reviews in the Neurosciences
volume
24
issue
4
pages
415 - 429
publisher
Freund Publishing House Ltd
external identifiers
  • wos:000322972500006
  • scopus:84888180105
ISSN
0334-1763
DOI
10.1515/revneuro-2013-0018
language
English
LU publication?
yes
id
3abe70b7-24f9-48d5-bf65-65dbc25d701a (old id 4033751)
date added to LUP
2013-10-01 15:15:16
date last changed
2019-08-28 02:52:13
@article{3abe70b7-24f9-48d5-bf65-65dbc25d701a,
  abstract     = {A common observation in recordings of neuronal activity from the cerebral cortex is that populations of neurons show patterns of synchronized oscillatory activity. However, it has been suggested that neuronal synchronization can, in certain pathological conditions, become excessive and possibly have a pathogenic role. In particular, aberrant oscillatory activation patterns have been implicated in conditions involving cortical dysfunction. We here review the mechanisms thought to be involved in the generation of cortical oscillations and discuss their relevance in relation to a recent finding indicating that high-frequency oscillations in the cerebral cortex have an important role in the generation of levodopa-induced dyskinesia. On the basis of these insights, it is suggested that the identification of physiological changes associated with symptoms of disease is a particularly important first step toward a more rapid development of novel treatment strategies.},
  author       = {Richter, Ulrike and Halje, Pär and Petersson, Per},
  issn         = {0334-1763},
  keyword      = {basal ganglia,dopamine,motor cortex,neuronal circuits,oscillations,Parkinson's disease},
  language     = {eng},
  number       = {4},
  pages        = {415--429},
  publisher    = {Freund Publishing House Ltd},
  series       = {Reviews in the Neurosciences},
  title        = {Mechanisms underlying cortical resonant states: implications for levodopa-induced dyskinesia},
  url          = {http://dx.doi.org/10.1515/revneuro-2013-0018},
  volume       = {24},
  year         = {2013},
}