Radiation dosimetry for indium-111-labeled anti-CEA-F(ab')2 fragments evaluated from tissue distribution in rats
(1992) In Journal of Nuclear Medicine 33(9). p.1654-1660- Abstract
- Accurate dosimetric investigations are important to be able to fulfill the ambition of radiation protection in nuclear medicine and to minimize the radiation burden to the patient. This paper presents human radiation absorbed dose estimates following an administration of an 111In-labeled anti-CEA-F(ab')2 (BW431/31) based on detailed biodistribution and elimination data in a rat model. Animals were followed from the time of injection up to 28 days after injection. A significant initial uptake of 111In in the bone marrow, 25% of injected activity, was evident after 6 hr. The kidneys showed a maximal uptake of 20% at 24 hr. At the end of the study, 27% of the activity was still retained in the whole body. The estimated humans absorbed dose to... (More)
- Accurate dosimetric investigations are important to be able to fulfill the ambition of radiation protection in nuclear medicine and to minimize the radiation burden to the patient. This paper presents human radiation absorbed dose estimates following an administration of an 111In-labeled anti-CEA-F(ab')2 (BW431/31) based on detailed biodistribution and elimination data in a rat model. Animals were followed from the time of injection up to 28 days after injection. A significant initial uptake of 111In in the bone marrow, 25% of injected activity, was evident after 6 hr. The kidneys showed a maximal uptake of 20% at 24 hr. At the end of the study, 27% of the activity was still retained in the whole body. The estimated humans absorbed dose to the kidneys, testes, spleen and bone marrow was 2.27, 0.80, 0.51 and 0.37 mGy MBq-1, respectively. The effective dose was estimated to 0.27 mSv MBq-1. The tissue distribution in rats was comparable to that in humans, which was confirmed by whole-body scintigrams and human biopsies (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1106950
- author
- Jönsson, Bo-Anders LU ; Strand, Sven-Erik LU and Andersson, Lena
- organization
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Nuclear Medicine
- volume
- 33
- issue
- 9
- pages
- 1654 - 1660
- publisher
- Society of Nuclear Medicine
- external identifiers
-
- scopus:0026702710
- ISSN
- 0161-5505
- language
- English
- LU publication?
- yes
- id
- 3ad36611-42e8-442c-82c7-f4e0469c9255 (old id 1106950)
- alternative location
- http://jnm.snmjournals.org/cgi/reprint/33/9/1654
- date added to LUP
- 2016-04-01 15:44:58
- date last changed
- 2021-01-03 07:53:49
@article{3ad36611-42e8-442c-82c7-f4e0469c9255,
abstract = {{Accurate dosimetric investigations are important to be able to fulfill the ambition of radiation protection in nuclear medicine and to minimize the radiation burden to the patient. This paper presents human radiation absorbed dose estimates following an administration of an 111In-labeled anti-CEA-F(ab')2 (BW431/31) based on detailed biodistribution and elimination data in a rat model. Animals were followed from the time of injection up to 28 days after injection. A significant initial uptake of 111In in the bone marrow, 25% of injected activity, was evident after 6 hr. The kidneys showed a maximal uptake of 20% at 24 hr. At the end of the study, 27% of the activity was still retained in the whole body. The estimated humans absorbed dose to the kidneys, testes, spleen and bone marrow was 2.27, 0.80, 0.51 and 0.37 mGy MBq-1, respectively. The effective dose was estimated to 0.27 mSv MBq-1. The tissue distribution in rats was comparable to that in humans, which was confirmed by whole-body scintigrams and human biopsies}},
author = {{Jönsson, Bo-Anders and Strand, Sven-Erik and Andersson, Lena}},
issn = {{0161-5505}},
language = {{eng}},
number = {{9}},
pages = {{1654--1660}},
publisher = {{Society of Nuclear Medicine}},
series = {{Journal of Nuclear Medicine}},
title = {{Radiation dosimetry for indium-111-labeled anti-CEA-F(ab')2 fragments evaluated from tissue distribution in rats}},
url = {{http://jnm.snmjournals.org/cgi/reprint/33/9/1654}},
volume = {{33}},
year = {{1992}},
}