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The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence

Pussinen, Pirkko J. ; Sarna, Seppo ; Puolakkainen, Mirja ; Öhlin, Hans LU ; Sorsa, Timo and Pesonen, Erkki LU (2013) In International Journal of Cardiology 167(2). p.362-368
Abstract
Background: Matrix metalloproteinase-8 (MMP-8) is involved in the breakdown of the extracellular matrix increasing the vulnerability of atherosclerotic lesions. We analysed the diagnostic value of serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in acute coronary syndrome (ACS) and their prognostic value in ACS recurrence. Methods: The population comprised 343 patients with ACS [including 108 unstable angina pectoris and 235 acute myocardial infarctions (AMI)] and 326 healthy controls. Additionally, 157 (45.8%) patients were resampled during the recovery. The ACS patients were followed up for 6 years. Results: MMP-8, TIMP-1, and their molar ratio distinguished the cases from the controls; C-statistic of the... (More)
Background: Matrix metalloproteinase-8 (MMP-8) is involved in the breakdown of the extracellular matrix increasing the vulnerability of atherosclerotic lesions. We analysed the diagnostic value of serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in acute coronary syndrome (ACS) and their prognostic value in ACS recurrence. Methods: The population comprised 343 patients with ACS [including 108 unstable angina pectoris and 235 acute myocardial infarctions (AMI)] and 326 healthy controls. Additionally, 157 (45.8%) patients were resampled during the recovery. The ACS patients were followed up for 6 years. Results: MMP-8, TIMP-1, and their molar ratio distinguished the cases from the controls; C-statistic of the multivariate model (95% CI, p-value) including the MMP-8/TIMP-1 ratio regarding its discriminating ability for AMI was 0.922 (0.893-0.950, p < 0.001). After the acute phase of ACS, median MMP-8 and TIMP-1 concentrations decreased (p < 0.001) by 34.5 and 28.7%, respectively, but ended up on a different level than those found in the controls. In the follow-up, acute phase and recovery period TIMP-1 concentrations associated with cardiovascular death with hazard ratios 4.31 (2.00-9.26, p < 0.001) and 4.69 (1.10-20.01, p = 0.037), respectively. Conclusions: The increase of serum MMP-8 and TIMP-1 concentrations may reflect plaque instability and tissue damage. TIMP-1 concentrations are associated with poor outcome in patients with ACS. The findings may have practical implications in both diagnostics and therapeutics. (c) 2011 Elsevier Ireland Ltd. All rights reserved. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Acute coronary syndrome, Acute myocardial infarction, Unstable angina, pectoris, Inflammation, Matrix metalloproteinase-8, Tissue inhibitor of, metalloproteinases-1
in
International Journal of Cardiology
volume
167
issue
2
pages
362 - 368
publisher
Elsevier
external identifiers
  • wos:000320768800020
  • scopus:84879069722
  • pmid:22257687
ISSN
0167-5273
DOI
10.1016/j.ijcard.2011.12.095
language
English
LU publication?
yes
id
3b357693-0fff-4275-a57e-f0b06690eedc (old id 3979518)
date added to LUP
2016-04-01 10:32:46
date last changed
2022-04-12 07:23:50
@article{3b357693-0fff-4275-a57e-f0b06690eedc,
  abstract     = {{Background: Matrix metalloproteinase-8 (MMP-8) is involved in the breakdown of the extracellular matrix increasing the vulnerability of atherosclerotic lesions. We analysed the diagnostic value of serum MMP-8 and tissue inhibitor of metalloproteinase-1 (TIMP-1) concentrations in acute coronary syndrome (ACS) and their prognostic value in ACS recurrence. Methods: The population comprised 343 patients with ACS [including 108 unstable angina pectoris and 235 acute myocardial infarctions (AMI)] and 326 healthy controls. Additionally, 157 (45.8%) patients were resampled during the recovery. The ACS patients were followed up for 6 years. Results: MMP-8, TIMP-1, and their molar ratio distinguished the cases from the controls; C-statistic of the multivariate model (95% CI, p-value) including the MMP-8/TIMP-1 ratio regarding its discriminating ability for AMI was 0.922 (0.893-0.950, p &lt; 0.001). After the acute phase of ACS, median MMP-8 and TIMP-1 concentrations decreased (p &lt; 0.001) by 34.5 and 28.7%, respectively, but ended up on a different level than those found in the controls. In the follow-up, acute phase and recovery period TIMP-1 concentrations associated with cardiovascular death with hazard ratios 4.31 (2.00-9.26, p &lt; 0.001) and 4.69 (1.10-20.01, p = 0.037), respectively. Conclusions: The increase of serum MMP-8 and TIMP-1 concentrations may reflect plaque instability and tissue damage. TIMP-1 concentrations are associated with poor outcome in patients with ACS. The findings may have practical implications in both diagnostics and therapeutics. (c) 2011 Elsevier Ireland Ltd. All rights reserved.}},
  author       = {{Pussinen, Pirkko J. and Sarna, Seppo and Puolakkainen, Mirja and Öhlin, Hans and Sorsa, Timo and Pesonen, Erkki}},
  issn         = {{0167-5273}},
  keywords     = {{Acute coronary syndrome; Acute myocardial infarction; Unstable angina; pectoris; Inflammation; Matrix metalloproteinase-8; Tissue inhibitor of; metalloproteinases-1}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{362--368}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Cardiology}},
  title        = {{The balance of serum matrix metalloproteinase-8 and its tissue inhibitor in acute coronary syndrome and its recurrence}},
  url          = {{https://lup.lub.lu.se/search/files/1934019/4178498.pdf}},
  doi          = {{10.1016/j.ijcard.2011.12.095}},
  volume       = {{167}},
  year         = {{2013}},
}