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Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems

Hazell, Gavin ; Arnold, Thomas ; Barker, Robert D. ; Clifton, Luke A. ; Steinke, Nina Juliane ; Tognoloni, Cecilia and Edler, Karen J. LU orcid (2016) In Langmuir 32(45). p.11845-11853
Abstract

Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such "nanodiscs" and lipid monolayers adsorbed at either solid-liquid or air-liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Langmuir
volume
32
issue
45
pages
9 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • scopus:84995790200
ISSN
0743-7463
DOI
10.1021/acs.langmuir.6b02927
language
English
LU publication?
no
additional info
Publisher Copyright: © 2016 American Chemical Society.
id
3b3c63a1-50df-495e-97d0-f9488d4b1387
date added to LUP
2023-01-18 09:17:14
date last changed
2023-02-17 10:30:25
@article{3b3c63a1-50df-495e-97d0-f9488d4b1387,
  abstract     = {{<p>Styrene-alt-maleic acid lipid particles (SMALPs) are self-assembled discoidal structures composed of a polymer belt and a segment of lipid bilayer, which are capable of encapsulating membrane proteins directly from the cell membrane. Here we present evidence of the exchange of lipids between such "nanodiscs" and lipid monolayers adsorbed at either solid-liquid or air-liquid interfaces. This behavior has important implications for the potential uses of nanodiscs.</p>}},
  author       = {{Hazell, Gavin and Arnold, Thomas and Barker, Robert D. and Clifton, Luke A. and Steinke, Nina Juliane and Tognoloni, Cecilia and Edler, Karen J.}},
  issn         = {{0743-7463}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{45}},
  pages        = {{11845--11853}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Langmuir}},
  title        = {{Evidence of Lipid Exchange in Styrene Maleic Acid Lipid Particle (SMALP) Nanodisc Systems}},
  url          = {{http://dx.doi.org/10.1021/acs.langmuir.6b02927}},
  doi          = {{10.1021/acs.langmuir.6b02927}},
  volume       = {{32}},
  year         = {{2016}},
}