Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function

Chung, Youn Wook ; Ahmad, Faiyaz ; Tang, Yan LU ; Hockman, Steven C. ; Kee, Hyun Jung ; Berger, Karin LU orcid ; Guirguis, Emilia ; Choi, Young Hun ; Schimel, Dan M. and Aponte, Angel M. , et al. (2017) In Scientific Reports 7.
Abstract

Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects a potential strategy in the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) is very important in the development of the beige phenotype and activation of its thermogenic program. To study effects of cyclic nucleotides on energy homeostatic mechanisms, mice were generated by targeted inactivation of cyclic nucleotide phosphodiesterase 3b (Pde3b) gene, which encodes PDE3B, an enzyme that catalyzes hydrolysis of cAMP and cGMP and is highly expressed in tissues that regulate energy homeostasis, including adipose tissue, liver, and pancreas. In epididymal white adipose tissue (eWAT) of PDE3B KO mice... (More)

Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects a potential strategy in the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) is very important in the development of the beige phenotype and activation of its thermogenic program. To study effects of cyclic nucleotides on energy homeostatic mechanisms, mice were generated by targeted inactivation of cyclic nucleotide phosphodiesterase 3b (Pde3b) gene, which encodes PDE3B, an enzyme that catalyzes hydrolysis of cAMP and cGMP and is highly expressed in tissues that regulate energy homeostasis, including adipose tissue, liver, and pancreas. In epididymal white adipose tissue (eWAT) of PDE3B KO mice on a SvJ129 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase (AMPK) signaling pathways are activated, resulting in "browning" phenotype, with a smaller increases in body weight under high-fat diet, smaller fat deposits, increased β-oxidation of fatty acids (FAO) and oxygen consumption. Results reported here suggest that PDE3B and/or its downstream signaling partners might be important regulators of energy metabolism in adipose tissue, and potential therapeutic targets for treating obesity, diabetes and their associated metabolic disorders.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
7
article number
40445
publisher
Nature Publishing Group
external identifiers
  • pmid:28084425
  • wos:000392172500001
  • scopus:85009486586
ISSN
2045-2322
DOI
10.1038/srep40445
language
English
LU publication?
yes
id
3b4963c8-d884-4529-a861-f1440cdfea98
date added to LUP
2017-02-28 12:19:27
date last changed
2024-02-29 10:20:19
@article{3b4963c8-d884-4529-a861-f1440cdfea98,
  abstract     = {{<p>Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects a potential strategy in the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) is very important in the development of the beige phenotype and activation of its thermogenic program. To study effects of cyclic nucleotides on energy homeostatic mechanisms, mice were generated by targeted inactivation of cyclic nucleotide phosphodiesterase 3b (Pde3b) gene, which encodes PDE3B, an enzyme that catalyzes hydrolysis of cAMP and cGMP and is highly expressed in tissues that regulate energy homeostasis, including adipose tissue, liver, and pancreas. In epididymal white adipose tissue (eWAT) of PDE3B KO mice on a SvJ129 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase (AMPK) signaling pathways are activated, resulting in "browning" phenotype, with a smaller increases in body weight under high-fat diet, smaller fat deposits, increased β-oxidation of fatty acids (FAO) and oxygen consumption. Results reported here suggest that PDE3B and/or its downstream signaling partners might be important regulators of energy metabolism in adipose tissue, and potential therapeutic targets for treating obesity, diabetes and their associated metabolic disorders.</p>}},
  author       = {{Chung, Youn Wook and Ahmad, Faiyaz and Tang, Yan and Hockman, Steven C. and Kee, Hyun Jung and Berger, Karin and Guirguis, Emilia and Choi, Young Hun and Schimel, Dan M. and Aponte, Angel M. and Park, Sunhee and Degerman, Eva and Manganiello, Vincent C}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  month        = {{01}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function}},
  url          = {{http://dx.doi.org/10.1038/srep40445}},
  doi          = {{10.1038/srep40445}},
  volume       = {{7}},
  year         = {{2017}},
}