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Long-term exposure to transportation noise and risk of incident stroke : A pooled study of nine scandinavian cohorts

Roswall, Nina ; Pyko, Andrei ; Ögren, Mikael ; Oudin, Anna LU ; Rosengren, Annika ; Lager, Anton ; Poulsen, Aslak H. ; Eriksson, Charlotta ; Segersson, David and Rizzuto, Debora , et al. (2021) In Environmental Health Perspectives 129(10).
Abstract

BACKGROUND: Transportation noise is increasingly acknowledged as a cardiovascular risk factor, but the evidence base for an association with stroke is sparse. OBJECTIVE: We aimed to investigate the association between transportation noise and stroke incidence in a large Scandinavian population. METHODS: We harmonized and pooled data from nine Scandinavian cohorts (seven Swedish, two Danish), totaling 135,951 participants. We identified residential address history and estimated road, railway, and aircraft noise for all addresses. Information on stroke incidence was acquired through link-age to national patient and mortality registries. We analyzed data using Cox proportional hazards models, including socioeconomic and lifestyle... (More)

BACKGROUND: Transportation noise is increasingly acknowledged as a cardiovascular risk factor, but the evidence base for an association with stroke is sparse. OBJECTIVE: We aimed to investigate the association between transportation noise and stroke incidence in a large Scandinavian population. METHODS: We harmonized and pooled data from nine Scandinavian cohorts (seven Swedish, two Danish), totaling 135,951 participants. We identified residential address history and estimated road, railway, and aircraft noise for all addresses. Information on stroke incidence was acquired through link-age to national patient and mortality registries. We analyzed data using Cox proportional hazards models, including socioeconomic and lifestyle con-founders, and air pollution. RESULTS: During follow-up (median = 19:5 y), 11,056 stroke cases were identified. Road traffic noise (Lden ) was associated with risk of stroke, with a hazard ratio (HR) of 1.06 [95% confidence interval (CI): 1.03, 1.08] per 10-dB higher 5-y mean time-weighted exposure in analyses adjusted for indi-vidual-and area-level socioeconomic covariates. The association was approximately linear and persisted after adjustment for air pollution [particulate matter (PM) with an aerodynamic diameter of ≤2:5 lm (PM2:5 ) and NO2 ]. Stroke was associated with moderate levels of 5-y aircraft noise exposure (40–50 vs. ≤40 dB) (HR = 1:12; 95% CI: 0.99, 1.27), but not with higher exposure (≥50 dB, HR = 0:94; 95% CI: 0.79, 1.11). Railway noise was not associated with stroke. DISCUSSION: In this pooled study, road traffic noise was associated with a higher risk of stroke. This finding supports road traffic noise as an important cardiovascular risk factor that should be included when estimating the burden of disease due to traffic noise. https://doi.org/10.1289/EHP8949.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Health Perspectives
volume
129
issue
10
article number
107002
publisher
National Institute of Environmental Health Sciences
external identifiers
  • pmid:34605674
  • scopus:85117630033
ISSN
0091-6765
DOI
10.1289/EHP8949
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021, Public Health Services, US Dept of Health and Human Services. All rights reserved.
id
3b612bf8-7c06-476c-b232-c98b8b3490be
date added to LUP
2021-11-22 10:34:07
date last changed
2022-11-24 01:33:15
@article{3b612bf8-7c06-476c-b232-c98b8b3490be,
  abstract     = {{<p>BACKGROUND: Transportation noise is increasingly acknowledged as a cardiovascular risk factor, but the evidence base for an association with stroke is sparse. OBJECTIVE: We aimed to investigate the association between transportation noise and stroke incidence in a large Scandinavian population. METHODS: We harmonized and pooled data from nine Scandinavian cohorts (seven Swedish, two Danish), totaling 135,951 participants. We identified residential address history and estimated road, railway, and aircraft noise for all addresses. Information on stroke incidence was acquired through link-age to national patient and mortality registries. We analyzed data using Cox proportional hazards models, including socioeconomic and lifestyle con-founders, and air pollution. RESULTS: During follow-up (median = 19:5 y), 11,056 stroke cases were identified. Road traffic noise (L<sub>den</sub> ) was associated with risk of stroke, with a hazard ratio (HR) of 1.06 [95% confidence interval (CI): 1.03, 1.08] per 10-dB higher 5-y mean time-weighted exposure in analyses adjusted for indi-vidual-and area-level socioeconomic covariates. The association was approximately linear and persisted after adjustment for air pollution [particulate matter (PM) with an aerodynamic diameter of ≤2:5 lm (PM<sub>2:5</sub> ) and NO<sub>2</sub> ]. Stroke was associated with moderate levels of 5-y aircraft noise exposure (40–50 vs. ≤40 dB) (HR = 1:12; 95% CI: 0.99, 1.27), but not with higher exposure (≥50 dB, HR = 0:94; 95% CI: 0.79, 1.11). Railway noise was not associated with stroke. DISCUSSION: In this pooled study, road traffic noise was associated with a higher risk of stroke. This finding supports road traffic noise as an important cardiovascular risk factor that should be included when estimating the burden of disease due to traffic noise. https://doi.org/10.1289/EHP8949.</p>}},
  author       = {{Roswall, Nina and Pyko, Andrei and Ögren, Mikael and Oudin, Anna and Rosengren, Annika and Lager, Anton and Poulsen, Aslak H. and Eriksson, Charlotta and Segersson, David and Rizzuto, Debora and Andersson, Eva M. and Aasvang, Gunn Marit and Engström, Gunnar and Jørgensen, Jeanette T. and Selander, Jenny and Christensen, Jesper H. and Thacher, Jesse and Leander, Karin and Overvad, Kim and Eneroth, Kristina and Mattisson, Kristoffer and Barregård, Lars and Stockfelt, Leo and Albin, Maria and Ketzel, Matthias and Simonsen, Mette K. and Spanne, Mårten and Raaschou-Nielsen, Ole and Magnusson, Patrik K.E. and Tiittanen, Pekka and Molnar, Peter and Ljungman, Petter and Lanki, Timo and Lim, Youn Hee and Andersen, Zorana J. and Pershagen, Göran and Sørensen, Mette}},
  issn         = {{0091-6765}},
  language     = {{eng}},
  number       = {{10}},
  publisher    = {{National Institute of Environmental Health Sciences}},
  series       = {{Environmental Health Perspectives}},
  title        = {{Long-term exposure to transportation noise and risk of incident stroke : A pooled study of nine scandinavian cohorts}},
  url          = {{http://dx.doi.org/10.1289/EHP8949}},
  doi          = {{10.1289/EHP8949}},
  volume       = {{129}},
  year         = {{2021}},
}