Time trends of coronary procedures, guideline-based drugs and all-cause mortality following acute coronary syndrome in patients with bipolar disorder
Philipsen, Line ; Würtz, Nanna ; Polcwiartek, Christoffer ; Kragholm, Kristian Hay ; Torp-Pedersen, Christian ; Nielsen, Rene Ernst ; Jensen, Svend Eggert and Attar, Rubina LU
(2023)
In Nordic Journal of Psychiatry
77(3).
p.304-311
- Abstract
Aim: This study analyzed time trends in the use of coronary procedures, guideline-based drugs, and 1-year all-cause and presumed cardiovascular mortality (CV) following acute coronary syndrome (ACS) in patients with and without bipolar disorder (BD). Method: Using Danish registries 497 patients with ACS and BD in the period 1996–2016 were matched 1:2 on age, sex and year of ACS to patients without preexisting psychiatric disease. Results: Patients with BD and ACS received fewer coronary angiography (CAG) compared to psychiatric healthy controls (PHC). However, the difference between the populations decreased over time. For percutaneous coronary intervention (PCI) and coronary artery bypass (CABG) no differences in trend over time were... (More)
Aim: This study analyzed time trends in the use of coronary procedures, guideline-based drugs, and 1-year all-cause and presumed cardiovascular mortality (CV) following acute coronary syndrome (ACS) in patients with and without bipolar disorder (BD). Method: Using Danish registries 497 patients with ACS and BD in the period 1996–2016 were matched 1:2 on age, sex and year of ACS to patients without preexisting psychiatric disease. Results: Patients with BD and ACS received fewer coronary angiography (CAG) compared to psychiatric healthy controls (PHC). However, the difference between the populations decreased over time. For percutaneous coronary intervention (PCI) and coronary artery bypass (CABG) no differences in trend over time were found. In general patients with BD redeemed fewer prescriptions of guideline-based tertiary prophylactic drugs compared to PHCs. The difference remains constant over time for all drugs except for acetylsalicylic acid, lipid-lowering drugs and beta blockers, where the difference decreased. The 1-year all-cause mortality gap and the presumed CV mortality gap remained unchanged. Conclusion: Despite improvements in treatment disparities regarding CAG, acetylsalicylic acid, lipid-lowering drugs and beta-blockers, the treatment gap remained unchanged concerning PCI and CABG. Likewise, patients with BD experienced a lower rate of the remaining redeemed prescriptions. The overall crude mortality risk ratio for patients with BD experiencing ACS remained unchanged over the study period compared to PHC.
(Less)
- author
- Philipsen, Line
; Würtz, Nanna
; Polcwiartek, Christoffer
; Kragholm, Kristian Hay
; Torp-Pedersen, Christian
; Nielsen, Rene Ernst
; Jensen, Svend Eggert
and Attar, Rubina
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- bipolar disorder, Cardiovascular diseases, coronary angiography
- in
- Nordic Journal of Psychiatry
- volume
- 77
- issue
- 3
- pages
- 304 - 311
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:35904234
- scopus:85135163746
- ISSN
- 0803-9488
- DOI
- 10.1080/08039488.2022.2102208
- language
- English
- LU publication?
- yes
- id
- 3b8b08e4-7c36-4032-9540-6cddd65cb419
- date added to LUP
- 2022-10-07 14:05:43
- date last changed
- 2024-06-27 21:24:43
@article{3b8b08e4-7c36-4032-9540-6cddd65cb419,
abstract = {{<p>Aim: This study analyzed time trends in the use of coronary procedures, guideline-based drugs, and 1-year all-cause and presumed cardiovascular mortality (CV) following acute coronary syndrome (ACS) in patients with and without bipolar disorder (BD). Method: Using Danish registries 497 patients with ACS and BD in the period 1996–2016 were matched 1:2 on age, sex and year of ACS to patients without preexisting psychiatric disease. Results: Patients with BD and ACS received fewer coronary angiography (CAG) compared to psychiatric healthy controls (PHC). However, the difference between the populations decreased over time. For percutaneous coronary intervention (PCI) and coronary artery bypass (CABG) no differences in trend over time were found. In general patients with BD redeemed fewer prescriptions of guideline-based tertiary prophylactic drugs compared to PHCs. The difference remains constant over time for all drugs except for acetylsalicylic acid, lipid-lowering drugs and beta blockers, where the difference decreased. The 1-year all-cause mortality gap and the presumed CV mortality gap remained unchanged. Conclusion: Despite improvements in treatment disparities regarding CAG, acetylsalicylic acid, lipid-lowering drugs and beta-blockers, the treatment gap remained unchanged concerning PCI and CABG. Likewise, patients with BD experienced a lower rate of the remaining redeemed prescriptions. The overall crude mortality risk ratio for patients with BD experiencing ACS remained unchanged over the study period compared to PHC.</p>}},
author = {{Philipsen, Line and Würtz, Nanna and Polcwiartek, Christoffer and Kragholm, Kristian Hay and Torp-Pedersen, Christian and Nielsen, Rene Ernst and Jensen, Svend Eggert and Attar, Rubina}},
issn = {{0803-9488}},
keywords = {{bipolar disorder; Cardiovascular diseases; coronary angiography}},
language = {{eng}},
number = {{3}},
pages = {{304--311}},
publisher = {{Informa Healthcare}},
series = {{Nordic Journal of Psychiatry}},
title = {{Time trends of coronary procedures, guideline-based drugs and all-cause mortality following acute coronary syndrome in patients with bipolar disorder}},
url = {{http://dx.doi.org/10.1080/08039488.2022.2102208}},
doi = {{10.1080/08039488.2022.2102208}},
volume = {{77}},
year = {{2023}},
}