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Risk of multiple colorectal cancer development depends on age and subgroup in individuals with hereditary predisposition

Lindberg, Lars J. ; Wegen-Haitsma, Wia ; Ladelund, Steen ; Smith-Hansen, Lars ; Therkildsen, Christina LU ; Bernstein, Inge and Nilbert, Mef LU (2019) In Familial Cancer 18(2). p.183-191
Abstract

Development of multiple colorectal cancers (CRCs), synchronously or metachronously, is associated with hereditary predisposition for cancer and accurate risk estimates of multiple tumour development are relevant to recommend rational surveillance programs. A cross-sectional study design was used to estimate the risks of synchronous CRC (SCRC) and metachronous CRC (MCRC) based on data from the National Danish Hereditary Nonpolyposis Register. In total, 7100 individuals from families within the subgroups Lynch syndrome, familial CRC (FCC) and moderate risk were used with estimates relative to a non-hereditary population control cohort. SCRC was diagnosed in 7.4% of the Lynch syndrome cases, in 4.2% of FCC cases and 2.5% of the moderate... (More)

Development of multiple colorectal cancers (CRCs), synchronously or metachronously, is associated with hereditary predisposition for cancer and accurate risk estimates of multiple tumour development are relevant to recommend rational surveillance programs. A cross-sectional study design was used to estimate the risks of synchronous CRC (SCRC) and metachronous CRC (MCRC) based on data from the National Danish Hereditary Nonpolyposis Register. In total, 7100 individuals from families within the subgroups Lynch syndrome, familial CRC (FCC) and moderate risk were used with estimates relative to a non-hereditary population control cohort. SCRC was diagnosed in 7.4% of the Lynch syndrome cases, in 4.2% of FCC cases and 2.5% of the moderate risk cases, which translated to relative risks of 1.9–5.6. The risk of MCRC was distinctively linked to Lynch syndrome with a life-time risk up to 70% and an incidence rate ratio of 5.0. The risk of SCRC was significantly increased in all subgroups of FCC and hereditary CRC, whereas the risk of MCRC was specifically linked to Lynch syndrome. These observations suggest that individuals with FCC or hereditary CRC should be carefully screened for second primary CRC at the time of diagnosis, whereas intensified surveillance for second primary CRC is motivated in Lynch syndrome with lower-intensity programs in families with yet unidentified genetic causes.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Colonoscopy, Cross-sectional study, HNPCC, Lynch syndrome, Metachronous neoplasms, Multiple primary neoplasms, Synchronous neoplasms
in
Familial Cancer
volume
18
issue
2
pages
183 - 191
publisher
Kluwer
external identifiers
  • scopus:85054831338
  • pmid:30302651
ISSN
1389-9600
DOI
10.1007/s10689-018-0109-z
language
English
LU publication?
yes
id
3b8e6efa-ebd6-4e97-bf3c-7adeb6981048
date added to LUP
2018-11-13 12:11:31
date last changed
2021-01-06 02:45:37
@article{3b8e6efa-ebd6-4e97-bf3c-7adeb6981048,
  abstract     = {<p>Development of multiple colorectal cancers (CRCs), synchronously or metachronously, is associated with hereditary predisposition for cancer and accurate risk estimates of multiple tumour development are relevant to recommend rational surveillance programs. A cross-sectional study design was used to estimate the risks of synchronous CRC (SCRC) and metachronous CRC (MCRC) based on data from the National Danish Hereditary Nonpolyposis Register. In total, 7100 individuals from families within the subgroups Lynch syndrome, familial CRC (FCC) and moderate risk were used with estimates relative to a non-hereditary population control cohort. SCRC was diagnosed in 7.4% of the Lynch syndrome cases, in 4.2% of FCC cases and 2.5% of the moderate risk cases, which translated to relative risks of 1.9–5.6. The risk of MCRC was distinctively linked to Lynch syndrome with a life-time risk up to 70% and an incidence rate ratio of 5.0. The risk of SCRC was significantly increased in all subgroups of FCC and hereditary CRC, whereas the risk of MCRC was specifically linked to Lynch syndrome. These observations suggest that individuals with FCC or hereditary CRC should be carefully screened for second primary CRC at the time of diagnosis, whereas intensified surveillance for second primary CRC is motivated in Lynch syndrome with lower-intensity programs in families with yet unidentified genetic causes.</p>},
  author       = {Lindberg, Lars J. and Wegen-Haitsma, Wia and Ladelund, Steen and Smith-Hansen, Lars and Therkildsen, Christina and Bernstein, Inge and Nilbert, Mef},
  issn         = {1389-9600},
  language     = {eng},
  number       = {2},
  pages        = {183--191},
  publisher    = {Kluwer},
  series       = {Familial Cancer},
  title        = {Risk of multiple colorectal cancer development depends on age and subgroup in individuals with hereditary predisposition},
  url          = {http://dx.doi.org/10.1007/s10689-018-0109-z},
  doi          = {10.1007/s10689-018-0109-z},
  volume       = {18},
  year         = {2019},
}