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Identifying New Antimigraine Targets : Lessons from Molecular Biology

Edvinsson, Lars LU and Haanes, Kristian Agmund (2021) In Trends in Pharmacological Sciences 42(4). p.217-225
Abstract

Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migraine pain, to provide novel aspects on how to modify the system and for the development of future treatments; acute as well as prophylactic. We explore the distribution and the expression of neuropeptides themselves, as well as certain ion channels, and most importantly how they may act in concert as modulators of excitability of both the... (More)

Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migraine pain, to provide novel aspects on how to modify the system and for the development of future treatments; acute as well as prophylactic. We explore the distribution and the expression of neuropeptides themselves, as well as certain ion channels, and most importantly how they may act in concert as modulators of excitability of both the trigeminal C neurons and the Aδ neurons.

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Please use this url to cite or link to this publication:
author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
C fibers, calcitonin gene-related peptide, node of Ranvier, Aδ fibers, trigeminovascular system, G-protein coupled receptors
in
Trends in Pharmacological Sciences
volume
42
issue
4
pages
217 - 225
publisher
Elsevier
external identifiers
  • pmid:33495027
  • scopus:85099971292
ISSN
0165-6147
DOI
10.1016/j.tips.2021.01.002
language
English
LU publication?
yes
id
3ba5bac0-d6f6-42ed-915c-3c749df51e97
date added to LUP
2021-02-08 11:20:17
date last changed
2024-03-21 01:48:17
@article{3ba5bac0-d6f6-42ed-915c-3c749df51e97,
  abstract     = {{<p>Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migraine pain, to provide novel aspects on how to modify the system and for the development of future treatments; acute as well as prophylactic. We explore the distribution and the expression of neuropeptides themselves, as well as certain ion channels, and most importantly how they may act in concert as modulators of excitability of both the trigeminal C neurons and the Aδ neurons.</p>}},
  author       = {{Edvinsson, Lars and Haanes, Kristian Agmund}},
  issn         = {{0165-6147}},
  keywords     = {{C fibers; calcitonin gene-related peptide; node of Ranvier, Aδ fibers; trigeminovascular system, G-protein coupled receptors}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{4}},
  pages        = {{217--225}},
  publisher    = {{Elsevier}},
  series       = {{Trends in Pharmacological Sciences}},
  title        = {{Identifying New Antimigraine Targets : Lessons from Molecular Biology}},
  url          = {{http://dx.doi.org/10.1016/j.tips.2021.01.002}},
  doi          = {{10.1016/j.tips.2021.01.002}},
  volume       = {{42}},
  year         = {{2021}},
}