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Neuropeptides : Active neuromodulators involved in the pathophysiology of suicidal behavior and major affective disorders

Serafini, Gianluca; Lindqvist, Daniel LU ; Brundin, Lena LU ; Dwivedi, Yogesh; Girardi, Paolo and Amore, Mario (2015) In Bioactive Natural Products: Chemistry and Biology p.409-442
Abstract

Neuropeptides, protein-like molecules used for direct communication between neurons, may play a critical role in the pathophysiology of mood disorders and suicidal behavior. This chapter aims to critically review the current literature on associations between neuropeptides, major affective disorders, and suicidal behavior. Most studies included in this overview reported an association between suicidality and corticotropin-releasing factor (CRF), VGF nerve growth factor inducible (VGF), cholecystokinin (CCK), orexin, substance P, and neuropeptide Y (NPY). It has been suggested that these molecules play a key role in many biological functions and act as important neuromodulators of emotional processing. The majority of the studies... (More)

Neuropeptides, protein-like molecules used for direct communication between neurons, may play a critical role in the pathophysiology of mood disorders and suicidal behavior. This chapter aims to critically review the current literature on associations between neuropeptides, major affective disorders, and suicidal behavior. Most studies included in this overview reported an association between suicidality and corticotropin-releasing factor (CRF), VGF nerve growth factor inducible (VGF), cholecystokinin (CCK), orexin, substance P, and neuropeptide Y (NPY). It has been suggested that these molecules play a key role in many biological functions and act as important neuromodulators of emotional processing. The majority of the studies reviewed in this chapter found that suicidal subjects display higher mean concentrations of various neuropeptides compared to control subjects although depressed patients and suicide completers may also display lower NPY levels throughout the brain compared to healthy controls or individuals deceased from causes other than suicide. In addition, some studies have reported that orexin and corticotropin-releasing hormone (CRH) levels are lower in suicidal patients. In spite of these cross-sectional reports, a causal link between neuropeptide dysregulation and suicidality cannot be determined. The main implications of the studies that are included in the present chapter are critically analyzed and discussed.

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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Biomarkers, Major depression, Neuropeptides, Suicidal behavior
in
Bioactive Natural Products: Chemistry and Biology
editor
Brahmachari, Goutam and
pages
34 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85019806315
ISBN
9783527337941
9783527684403
DOI
10.1002/9783527684403.ch15
language
English
LU publication?
yes
id
3ba7f379-0ef8-4ef6-b751-463fdf1f2577
date added to LUP
2017-06-16 14:04:48
date last changed
2017-06-16 14:04:48
@inbook{3ba7f379-0ef8-4ef6-b751-463fdf1f2577,
  abstract     = {<p>Neuropeptides, protein-like molecules used for direct communication between neurons, may play a critical role in the pathophysiology of mood disorders and suicidal behavior. This chapter aims to critically review the current literature on associations between neuropeptides, major affective disorders, and suicidal behavior. Most studies included in this overview reported an association between suicidality and corticotropin-releasing factor (CRF), VGF nerve growth factor inducible (VGF), cholecystokinin (CCK), orexin, substance P, and neuropeptide Y (NPY). It has been suggested that these molecules play a key role in many biological functions and act as important neuromodulators of emotional processing. The majority of the studies reviewed in this chapter found that suicidal subjects display higher mean concentrations of various neuropeptides compared to control subjects although depressed patients and suicide completers may also display lower NPY levels throughout the brain compared to healthy controls or individuals deceased from causes other than suicide. In addition, some studies have reported that orexin and corticotropin-releasing hormone (CRH) levels are lower in suicidal patients. In spite of these cross-sectional reports, a causal link between neuropeptide dysregulation and suicidality cannot be determined. The main implications of the studies that are included in the present chapter are critically analyzed and discussed.</p>},
  author       = {Serafini, Gianluca and Lindqvist, Daniel and Brundin, Lena and Dwivedi, Yogesh and Girardi, Paolo and Amore, Mario},
  editor       = {Brahmachari, Goutam},
  isbn         = {9783527337941},
  keyword      = {Biomarkers,Major depression,Neuropeptides,Suicidal behavior},
  language     = {eng},
  month        = {01},
  pages        = {409--442},
  publisher    = {Wiley-Blackwell},
  series       = {Bioactive Natural Products: Chemistry and Biology},
  title        = {Neuropeptides : Active neuromodulators involved in the pathophysiology of suicidal behavior and major affective disorders},
  url          = {http://dx.doi.org/10.1002/9783527684403.ch15},
  year         = {2015},
}