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Position paper : leveraging non-human primate (NHP) specificities to accelerate Parkinson's disease and ageing research

Bezard, Erwan ; Anderson, Rozalyn M ; Badin, Romina Aron ; Bergman, Hagai ; Boehringer, Ashley ; Borgognon, Simon ; Emborg, Marina E ; Kordower, Jeffrey H ; Li, Jia-Yi LU and Martel, Anne-Caroline , et al. (2025) In npj Parkinson's Disease 11. p.1-7
Abstract

The PD-AGE international task force underscores the pivotal role that non-human primate (NHP) models play in advancing our understanding of Parkinson's disease (PD) and ageing. Due to their close genetic, anatomical, and behavioural similarity to humans, NHPs uniquely enable translational research to bridge basic science towards clinical application. They are indispensable for modelling the complex motor and non-motor symptoms of PD, as well as age-related neurodegeneration. This paper outlines the scientific rationale, methodological strengths, and ethical considerations surrounding NHP use in PD research. We highlight the need for standardised models, innovative tools, and long-term collaborative infrastructure to enhance the... (More)

The PD-AGE international task force underscores the pivotal role that non-human primate (NHP) models play in advancing our understanding of Parkinson's disease (PD) and ageing. Due to their close genetic, anatomical, and behavioural similarity to humans, NHPs uniquely enable translational research to bridge basic science towards clinical application. They are indispensable for modelling the complex motor and non-motor symptoms of PD, as well as age-related neurodegeneration. This paper outlines the scientific rationale, methodological strengths, and ethical considerations surrounding NHP use in PD research. We highlight the need for standardised models, innovative tools, and long-term collaborative infrastructure to enhance the translational value of NHP studies. We propose a three-phase roadmap to develop a global research consortium to optimise resource use, improve model fidelity, and accelerate therapeutic development for PD and related neurodegenerative disorders.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
npj Parkinson's Disease
volume
11
article number
227
pages
1 - 7
publisher
Springer Nature
external identifiers
  • pmid:40753086
  • scopus:105012632686
ISSN
2373-8057
DOI
10.1038/s41531-025-01088-8
language
English
LU publication?
yes
additional info
© 2025. The Author(s).
id
3ba96d11-f0fa-4530-a17e-1ebcfac0c3ba
date added to LUP
2025-10-03 12:19:09
date last changed
2025-10-18 05:55:25
@article{3ba96d11-f0fa-4530-a17e-1ebcfac0c3ba,
  abstract     = {{<p>The PD-AGE international task force underscores the pivotal role that non-human primate (NHP) models play in advancing our understanding of Parkinson's disease (PD) and ageing. Due to their close genetic, anatomical, and behavioural similarity to humans, NHPs uniquely enable translational research to bridge basic science towards clinical application. They are indispensable for modelling the complex motor and non-motor symptoms of PD, as well as age-related neurodegeneration. This paper outlines the scientific rationale, methodological strengths, and ethical considerations surrounding NHP use in PD research. We highlight the need for standardised models, innovative tools, and long-term collaborative infrastructure to enhance the translational value of NHP studies. We propose a three-phase roadmap to develop a global research consortium to optimise resource use, improve model fidelity, and accelerate therapeutic development for PD and related neurodegenerative disorders.</p>}},
  author       = {{Bezard, Erwan and Anderson, Rozalyn M and Badin, Romina Aron and Bergman, Hagai and Boehringer, Ashley and Borgognon, Simon and Emborg, Marina E and Kordower, Jeffrey H and Li, Jia-Yi and Martel, Anne-Caroline and Metzger, Jeanette M and Smith, Yoland and Takada, Masahiko and Takahashi, Jun and Takahashi, Ryosuke and Dehay, Benjamin}},
  issn         = {{2373-8057}},
  language     = {{eng}},
  month        = {{08}},
  pages        = {{1--7}},
  publisher    = {{Springer Nature}},
  series       = {{npj Parkinson's Disease}},
  title        = {{Position paper : leveraging non-human primate (NHP) specificities to accelerate Parkinson's disease and ageing research}},
  url          = {{http://dx.doi.org/10.1038/s41531-025-01088-8}},
  doi          = {{10.1038/s41531-025-01088-8}},
  volume       = {{11}},
  year         = {{2025}},
}