The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment
(2013) In Reproductive BioMedicine Online 27(4). p.325-337- Abstract
- Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in the field of sperm DNA damage in the clinical setting. It explores current laboratory tests and the accumulating body of knowledge concerning the relationship between sperm DNA damage and clinical outcomes. The paper proceeds to discuss the strengths, weaknesses and clinical applicability of current sperm DNA tests. Next, the biological... (More)
- Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in the field of sperm DNA damage in the clinical setting. It explores current laboratory tests and the accumulating body of knowledge concerning the relationship between sperm DNA damage and clinical outcomes. The paper proceeds to discuss the strengths, weaknesses and clinical applicability of current sperm DNA tests. Next, the biological significance of DNA damage in the male germ line is considered. Finally, as sperm DNA damage is often the result of oxidative stress in the male reproductive tract, the potential contribution of antioxidant therapy in the clinical management of this condition is discussed. DNA damage in human spermatozoa is an important attribute of semen quality. It should be part of the clinical work up and properly controlled trials addressing the effectiveness of antioxidant therapy should be undertaken as a matter of urgency. (c) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4172125
- author
- Lewis, Sheena E. M. ; Aitken, R. John ; Conner, Sarah J. ; De Iuliis, Geoffry ; Evenson, Donald P. ; Henkel, Ralph ; Giwercman, Aleksander LU and Gharagozloo, Parviz
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- antioxidant therapy, assisted reproduction, DNA fragmentation, Male, infertility, oxidized bases, spermatozoa
- in
- Reproductive BioMedicine Online
- volume
- 27
- issue
- 4
- pages
- 325 - 337
- publisher
- Elsevier
- external identifiers
-
- wos:000325098200002
- scopus:84885191376
- ISSN
- 1472-6491
- DOI
- 10.1016/j.rbmo.2013.06.014
- language
- English
- LU publication?
- yes
- id
- 3bab81fa-e5d2-4c0a-8756-e1c9ffcb77c3 (old id 4172125)
- date added to LUP
- 2016-04-01 10:56:49
- date last changed
- 2024-03-24 21:49:59
@article{3bab81fa-e5d2-4c0a-8756-e1c9ffcb77c3,
abstract = {{Sperm DNA damage is a useful biomarker for male infertility diagnosis and prediction of assisted reproduction outcomes. It is associated with reduced fertilization rates, embryo quality and pregnancy rates, and higher rates of spontaneous miscarriage and childhood diseases. This review provides a synopsis of the most recent studies from each of the authors, all of whom have major track records in the field of sperm DNA damage in the clinical setting. It explores current laboratory tests and the accumulating body of knowledge concerning the relationship between sperm DNA damage and clinical outcomes. The paper proceeds to discuss the strengths, weaknesses and clinical applicability of current sperm DNA tests. Next, the biological significance of DNA damage in the male germ line is considered. Finally, as sperm DNA damage is often the result of oxidative stress in the male reproductive tract, the potential contribution of antioxidant therapy in the clinical management of this condition is discussed. DNA damage in human spermatozoa is an important attribute of semen quality. It should be part of the clinical work up and properly controlled trials addressing the effectiveness of antioxidant therapy should be undertaken as a matter of urgency. (c) 2013, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.}},
author = {{Lewis, Sheena E. M. and Aitken, R. John and Conner, Sarah J. and De Iuliis, Geoffry and Evenson, Donald P. and Henkel, Ralph and Giwercman, Aleksander and Gharagozloo, Parviz}},
issn = {{1472-6491}},
keywords = {{antioxidant therapy; assisted reproduction; DNA fragmentation; Male; infertility; oxidized bases; spermatozoa}},
language = {{eng}},
number = {{4}},
pages = {{325--337}},
publisher = {{Elsevier}},
series = {{Reproductive BioMedicine Online}},
title = {{The impact of sperm DNA damage in assisted conception and beyond: recent advances in diagnosis and treatment}},
url = {{http://dx.doi.org/10.1016/j.rbmo.2013.06.014}},
doi = {{10.1016/j.rbmo.2013.06.014}},
volume = {{27}},
year = {{2013}},
}