Myringosclerosis caused by increased oxygen concentration in traumatized tympanic membranes experimental study
Mattsson, Cecilia ; Magnuson, Karin LU
and Hellström, Sten
(1995)
In Annals of Otology, Rhinology & Laryngology
104(8).
p.625-632
- Abstract
The purpose of this study was to elucidate possible relationships between the oxygen concentration of the middle ear cavity and the development of myringosclerosis. Three groups of rats with myringotomized tympanic membranes were exposed to different oxygen concentrations of 10%, 15%, and 40%, respectively, for 1 week. A fourth group was kept in ambient air. Two other groups of rats with myringotomized and intubated tympanic membranes were exposed to oxygen concentrations of 10% and 40%, respectively, for the same period of time. Otomicroscopically, all hyperoxic animals had more numerous myringosclerotic lesions compared with the ambient air group, and also displayed a pronounced hyperplasia of the keratinizing epithelium around the... (More)
The purpose of this study was to elucidate possible relationships between the oxygen concentration of the middle ear cavity and the development of myringosclerosis. Three groups of rats with myringotomized tympanic membranes were exposed to different oxygen concentrations of 10%, 15%, and 40%, respectively, for 1 week. A fourth group was kept in ambient air. Two other groups of rats with myringotomized and intubated tympanic membranes were exposed to oxygen concentrations of 10% and 40%, respectively, for the same period of time. Otomicroscopically, all hyperoxic animals had more numerous myringosclerotic lesions compared with the ambient air group, and also displayed a pronounced hyperplasia of the keratinizing epithelium around the perforation border. By contrast, the hypoxic animals showed less pronounced myringosclerotic lesions or even completely lacked them. It is inferred that an increased oxygen concentration in the middle ear cavity will increase the likelihood of myringosclerotic deposits. The mechanism involved could be related to the formation of oxygen radicals.
(Less)
- author
- Mattsson, Cecilia
; Magnuson, Karin
LU
and Hellström, Sten
- publishing date
- 1995-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- hyperoxia, hypoxia, myringosclerosis, myringotomy, oxygen radicals, ventilation tubes
- in
- Annals of Otology, Rhinology & Laryngology
- volume
- 104
- issue
- 8
- pages
- 8 pages
- publisher
- Annals Publishing Company
- external identifiers
-
- scopus:0029150234
- pmid:7639472
- ISSN
- 0003-4894
- DOI
- 10.1177/000348949510400807
- language
- English
- LU publication?
- no
- id
- 3bcab1d2-f8b5-4c53-8d2b-d4136a24809c
- date added to LUP
- 2019-05-08 13:06:55
- date last changed
- 2024-01-01 03:34:40
@article{3bcab1d2-f8b5-4c53-8d2b-d4136a24809c,
abstract = {{<p>The purpose of this study was to elucidate possible relationships between the oxygen concentration of the middle ear cavity and the development of myringosclerosis. Three groups of rats with myringotomized tympanic membranes were exposed to different oxygen concentrations of 10%, 15%, and 40%, respectively, for 1 week. A fourth group was kept in ambient air. Two other groups of rats with myringotomized and intubated tympanic membranes were exposed to oxygen concentrations of 10% and 40%, respectively, for the same period of time. Otomicroscopically, all hyperoxic animals had more numerous myringosclerotic lesions compared with the ambient air group, and also displayed a pronounced hyperplasia of the keratinizing epithelium around the perforation border. By contrast, the hypoxic animals showed less pronounced myringosclerotic lesions or even completely lacked them. It is inferred that an increased oxygen concentration in the middle ear cavity will increase the likelihood of myringosclerotic deposits. The mechanism involved could be related to the formation of oxygen radicals.</p>}},
author = {{Mattsson, Cecilia and Magnuson, Karin and Hellström, Sten}},
issn = {{0003-4894}},
keywords = {{hyperoxia; hypoxia; myringosclerosis; myringotomy; oxygen radicals; ventilation tubes}},
language = {{eng}},
month = {{01}},
number = {{8}},
pages = {{625--632}},
publisher = {{Annals Publishing Company}},
series = {{Annals of Otology, Rhinology & Laryngology}},
title = {{Myringosclerosis caused by increased oxygen concentration in traumatized tympanic membranes experimental study}},
url = {{http://dx.doi.org/10.1177/000348949510400807}},
doi = {{10.1177/000348949510400807}},
volume = {{104}},
year = {{1995}},
}