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Skin exposure to scented products used in daily life and fragrance contact allergy in the European general population - The EDEN Fragrance Study

van Amerongen, Cynthia C.A. ; Ofenloch, Robert F. ; Cazzaniga, Simone ; Elsner, Peter ; Gonçalo, Margarida ; Naldi, Luigi ; Svensson, Åke LU ; Bruze, Magnus LU and Schuttelaar, Marie L.A. (2021) In Contact Dermatitis 84(6). p.385-394
Abstract

Background: Fragrances are widely used in scented products used in daily life with the potential to induce skin sensitization. Objective: To evaluate exposure to scented products and to explore associations between exposure and fragrance contact allergy. Methods: A cross-sectional study on individuals from 18 to 74 years of age, who were randomly selected from the general population in five European countries. A random sample (N = 3119) was patch tested and interviewed on exposure to scented products. Results: Female participants were strongly associated with exposure to scented products relative to male participants. Participants age 40 years and older showed an inverse association with exposure to scented products. Compared to Sweden,... (More)

Background: Fragrances are widely used in scented products used in daily life with the potential to induce skin sensitization. Objective: To evaluate exposure to scented products and to explore associations between exposure and fragrance contact allergy. Methods: A cross-sectional study on individuals from 18 to 74 years of age, who were randomly selected from the general population in five European countries. A random sample (N = 3119) was patch tested and interviewed on exposure to scented products. Results: Female participants were strongly associated with exposure to scented products relative to male participants. Participants age 40 years and older showed an inverse association with exposure to scented products. Compared to Sweden, The Netherlands followed by Germany showed the highest overall exposure to scented products. Sensitive skin was associated with exposure to scented products and with fragrance allergy. In univariable regression analysis, exposure to leave-on products and to specific scented product subgroups was significantly associated with fragrance allergy. Conclusion: Exposure to scented products depends primarily on sex and age. Female sex and sensitive skin are relevant indicators for developing fragrance allergy. Because aggregate exposure, especially to scented leave-on products, may enhance the prevalence of contact allergy to fragrances, further investigations into exposure amounts and frequencies is warranted.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
contact allergy, contact dermatitis, epidemiology, exposure, fragrances, household products, leave-on products, rinse-off products, scented products
in
Contact Dermatitis
volume
84
issue
6
pages
10 pages
publisher
Wiley-Blackwell
external identifiers
  • pmid:33576005
  • scopus:85101884308
ISSN
0105-1873
DOI
10.1111/cod.13807
language
English
LU publication?
yes
id
3bf30448-4bee-4417-a162-31735e79817d
date added to LUP
2022-03-01 15:29:19
date last changed
2024-04-04 03:55:31
@article{3bf30448-4bee-4417-a162-31735e79817d,
  abstract     = {{<p>Background: Fragrances are widely used in scented products used in daily life with the potential to induce skin sensitization. Objective: To evaluate exposure to scented products and to explore associations between exposure and fragrance contact allergy. Methods: A cross-sectional study on individuals from 18 to 74 years of age, who were randomly selected from the general population in five European countries. A random sample (N = 3119) was patch tested and interviewed on exposure to scented products. Results: Female participants were strongly associated with exposure to scented products relative to male participants. Participants age 40 years and older showed an inverse association with exposure to scented products. Compared to Sweden, The Netherlands followed by Germany showed the highest overall exposure to scented products. Sensitive skin was associated with exposure to scented products and with fragrance allergy. In univariable regression analysis, exposure to leave-on products and to specific scented product subgroups was significantly associated with fragrance allergy. Conclusion: Exposure to scented products depends primarily on sex and age. Female sex and sensitive skin are relevant indicators for developing fragrance allergy. Because aggregate exposure, especially to scented leave-on products, may enhance the prevalence of contact allergy to fragrances, further investigations into exposure amounts and frequencies is warranted.</p>}},
  author       = {{van Amerongen, Cynthia C.A. and Ofenloch, Robert F. and Cazzaniga, Simone and Elsner, Peter and Gonçalo, Margarida and Naldi, Luigi and Svensson, Åke and Bruze, Magnus and Schuttelaar, Marie L.A.}},
  issn         = {{0105-1873}},
  keywords     = {{contact allergy; contact dermatitis; epidemiology; exposure; fragrances; household products; leave-on products; rinse-off products; scented products}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{385--394}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Contact Dermatitis}},
  title        = {{Skin exposure to scented products used in daily life and fragrance contact allergy in the European general population - The EDEN Fragrance Study}},
  url          = {{http://dx.doi.org/10.1111/cod.13807}},
  doi          = {{10.1111/cod.13807}},
  volume       = {{84}},
  year         = {{2021}},
}