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Occurrence of substance P, vasoactive intestinal peptide and calcitonin gene-related peptide in dermographism and cold urticaria.

Wallengren, Joanna LU orcid ; Möller, Halvor LU and Ekman, Rolf (1987) In Archives of Dermatological Research 279(8). p.512-515
Abstract
Substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) were assayed in lesions and normal skin of patients with dermographism and cold urticaria utilizing suction-induced blisters. There was no difference in SP and VIP concentrations between challenged and control skin of urticaria patients. On the whole, however, the concentration of both neuropeptides, and VIP in particular, was higher in the urticaria patients than in control subjects. CGRP levels were not increased. SP and VIP in blood samples from veins draining challenged skin areas were below the detection limit. It is concluded that SP and VIP may potentiate histamine in wheal formation and thus contribute to the increased reactivity of... (More)
Substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) were assayed in lesions and normal skin of patients with dermographism and cold urticaria utilizing suction-induced blisters. There was no difference in SP and VIP concentrations between challenged and control skin of urticaria patients. On the whole, however, the concentration of both neuropeptides, and VIP in particular, was higher in the urticaria patients than in control subjects. CGRP levels were not increased. SP and VIP in blood samples from veins draining challenged skin areas were below the detection limit. It is concluded that SP and VIP may potentiate histamine in wheal formation and thus contribute to the increased reactivity of the skin to trauma and temperature changes in patients with physical urticaria. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Archives of Dermatological Research
volume
279
issue
8
pages
512 - 515
publisher
Springer
external identifiers
  • scopus:0023502648
ISSN
1432-069X
DOI
10.1007/BF00413281
language
English
LU publication?
yes
id
3c0712fe-a1f8-4278-84e6-bbb6c067ca08
date added to LUP
2019-07-25 15:29:45
date last changed
2021-05-09 05:46:07
@article{3c0712fe-a1f8-4278-84e6-bbb6c067ca08,
  abstract     = {{Substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) were assayed in lesions and normal skin of patients with dermographism and cold urticaria utilizing suction-induced blisters. There was no difference in SP and VIP concentrations between challenged and control skin of urticaria patients. On the whole, however, the concentration of both neuropeptides, and VIP in particular, was higher in the urticaria patients than in control subjects. CGRP levels were not increased. SP and VIP in blood samples from veins draining challenged skin areas were below the detection limit. It is concluded that SP and VIP may potentiate histamine in wheal formation and thus contribute to the increased reactivity of the skin to trauma and temperature changes in patients with physical urticaria.}},
  author       = {{Wallengren, Joanna and Möller, Halvor and Ekman, Rolf}},
  issn         = {{1432-069X}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{512--515}},
  publisher    = {{Springer}},
  series       = {{Archives of Dermatological Research}},
  title        = {{Occurrence of substance P, vasoactive intestinal peptide and calcitonin gene-related peptide in dermographism and cold urticaria.}},
  url          = {{http://dx.doi.org/10.1007/BF00413281}},
  doi          = {{10.1007/BF00413281}},
  volume       = {{279}},
  year         = {{1987}},
}