Occurrence of substance P, vasoactive intestinal peptide and calcitonin gene-related peptide in dermographism and cold urticaria.
(1987) In Archives of Dermatological Research 279(8). p.512-515- Abstract
- Substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) were assayed in lesions and normal skin of patients with dermographism and cold urticaria utilizing suction-induced blisters. There was no difference in SP and VIP concentrations between challenged and control skin of urticaria patients. On the whole, however, the concentration of both neuropeptides, and VIP in particular, was higher in the urticaria patients than in control subjects. CGRP levels were not increased. SP and VIP in blood samples from veins draining challenged skin areas were below the detection limit. It is concluded that SP and VIP may potentiate histamine in wheal formation and thus contribute to the increased reactivity of... (More)
- Substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) were assayed in lesions and normal skin of patients with dermographism and cold urticaria utilizing suction-induced blisters. There was no difference in SP and VIP concentrations between challenged and control skin of urticaria patients. On the whole, however, the concentration of both neuropeptides, and VIP in particular, was higher in the urticaria patients than in control subjects. CGRP levels were not increased. SP and VIP in blood samples from veins draining challenged skin areas were below the detection limit. It is concluded that SP and VIP may potentiate histamine in wheal formation and thus contribute to the increased reactivity of the skin to trauma and temperature changes in patients with physical urticaria. (Less)
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https://lup.lub.lu.se/record/3c0712fe-a1f8-4278-84e6-bbb6c067ca08
- author
- Wallengren, Joanna LU ; Möller, Halvor LU and Ekman, Rolf
- organization
- publishing date
- 1987
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Archives of Dermatological Research
- volume
- 279
- issue
- 8
- pages
- 512 - 515
- publisher
- Springer
- external identifiers
-
- scopus:0023502648
- ISSN
- 1432-069X
- DOI
- 10.1007/BF00413281
- language
- English
- LU publication?
- yes
- id
- 3c0712fe-a1f8-4278-84e6-bbb6c067ca08
- date added to LUP
- 2019-07-25 15:29:45
- date last changed
- 2021-05-09 05:46:07
@article{3c0712fe-a1f8-4278-84e6-bbb6c067ca08, abstract = {{Substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) were assayed in lesions and normal skin of patients with dermographism and cold urticaria utilizing suction-induced blisters. There was no difference in SP and VIP concentrations between challenged and control skin of urticaria patients. On the whole, however, the concentration of both neuropeptides, and VIP in particular, was higher in the urticaria patients than in control subjects. CGRP levels were not increased. SP and VIP in blood samples from veins draining challenged skin areas were below the detection limit. It is concluded that SP and VIP may potentiate histamine in wheal formation and thus contribute to the increased reactivity of the skin to trauma and temperature changes in patients with physical urticaria.}}, author = {{Wallengren, Joanna and Möller, Halvor and Ekman, Rolf}}, issn = {{1432-069X}}, language = {{eng}}, number = {{8}}, pages = {{512--515}}, publisher = {{Springer}}, series = {{Archives of Dermatological Research}}, title = {{Occurrence of substance P, vasoactive intestinal peptide and calcitonin gene-related peptide in dermographism and cold urticaria.}}, url = {{http://dx.doi.org/10.1007/BF00413281}}, doi = {{10.1007/BF00413281}}, volume = {{279}}, year = {{1987}}, }