Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer.
(2016) In Acta oncologica (Stockholm, Sweden) 55(3). p.96-286- Abstract
- Putative biomarkers of gemcitabine response have been extensively studied in pancreatic cancer, but less so in other types of periampullary adenocarcinoma. The most studied biomarker is human equilibrative nucleoside transporter 1 (hENT1), and the activating enzyme deoxycytidine kinase (dCK) has also been linked to treatment response. The RNA-binding protein human antigen R (HuR) has been demonstrated to confer increased dCK levels in vitro and to predict gemcitabine response in vivo. Here, we investigated the prognostic impact of hENT1, dCK and HuR in pancreatobiliary (PB) and intestinal (I) type periampullary cancers, respectively.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/8042509
- author
- Elebro, Jacob LU ; Ben Dror, Liv LU ; Heby, Margareta LU ; Nodin, Björn LU ; Jirström, Karin LU and Eberhard, Jakob LU
- organization
- publishing date
- 2016
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta oncologica (Stockholm, Sweden)
- volume
- 55
- issue
- 3
- pages
- 96 - 286
- publisher
- Taylor & Francis
- external identifiers
-
- pmid:26362587
- scopus:84941248673
- wos:000371249500005
- pmid:26362587
- ISSN
- 1651-226X
- DOI
- 10.3109/0284186X.2015.1075663
- language
- English
- LU publication?
- yes
- id
- 3c0991e8-6c2d-4184-b552-7d3f94b1e086 (old id 8042509)
- date added to LUP
- 2016-04-04 09:27:56
- date last changed
- 2024-01-29 02:52:54
@article{3c0991e8-6c2d-4184-b552-7d3f94b1e086, abstract = {{Putative biomarkers of gemcitabine response have been extensively studied in pancreatic cancer, but less so in other types of periampullary adenocarcinoma. The most studied biomarker is human equilibrative nucleoside transporter 1 (hENT1), and the activating enzyme deoxycytidine kinase (dCK) has also been linked to treatment response. The RNA-binding protein human antigen R (HuR) has been demonstrated to confer increased dCK levels in vitro and to predict gemcitabine response in vivo. Here, we investigated the prognostic impact of hENT1, dCK and HuR in pancreatobiliary (PB) and intestinal (I) type periampullary cancers, respectively.}}, author = {{Elebro, Jacob and Ben Dror, Liv and Heby, Margareta and Nodin, Björn and Jirström, Karin and Eberhard, Jakob}}, issn = {{1651-226X}}, language = {{eng}}, number = {{3}}, pages = {{96--286}}, publisher = {{Taylor & Francis}}, series = {{Acta oncologica (Stockholm, Sweden)}}, title = {{Prognostic effect of hENT1, dCK and HuR expression by morphological type in periampullary adenocarcinoma, including pancreatic cancer.}}, url = {{http://dx.doi.org/10.3109/0284186X.2015.1075663}}, doi = {{10.3109/0284186X.2015.1075663}}, volume = {{55}}, year = {{2016}}, }